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Development, Vol 124, Issue 1 219-231, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
PX Xu, I Woo, H Her, DR Beier and RL Maas
Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
We have identified and mapped three members of a new family of vertebrate genes, designated Eya1, Eya2 and Eya3, which share high sequence similarity with the Drosophila eyes absent (eya) gene. Comparison of all three murine Eya gene products and that encoded by the Drosophila eya gene defines a 271 amino acid carboxyl terminal Eya domain, which has been highly conserved during evolution. Eya1 and Eya2, which are closely related, are extensively expressed in cranial placodes, in the branchial arches and CNS and in complementary or overlapping patterns during organogenesis. Eya3 is also expressed in the branchial arches and CNS, but lacks cranial placode expression. All three Eya genes are expressed in the developing eye. Eyal is expressed in developing anterior chamber structures, including the lens placode, the iris and ciliary region and the prospective corneal ectoderm. Eyal is also expressed in retinal pigment epithelium and optic nerve. Eya2 is expressed in neural retina, sclera and optic nerve sheath. Moreover, Eya1 and Eya2 expressions in the lens and nasal placode overlap with and depend upon expression of Pax6. The high sequence similarity with Drosophila eya, the conserved developmental expression of Eya genes in the eye and the Pax6 dependence of Eya expression in the lens and nasal placode indicates that these genes likely represent functional homologues of the Drosophila eya gene. These results suggest that members of the Eya gene family play critical roles downstream of Pax genes in specifying placodal identity and support the idea that despite enormous morphological differences, the early development of insect and mammalian eyes is controlled by a conserved regulatory hierarchy.
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
B. Ring, S. Cordes, P. Overbeek, and G. Barsh Regulation of mouse lens fiber cell development and differentiation by the Maf gene Development, January 1, 2000; 127(2): 307 - 317. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Zimmerman, Q. T. Bui, H. Liu, and N. M. Bonini Molecular Genetic Analysis of Drosophila eyes absent Mutants Reveals an Eye Enhancer Element Genetics, January 1, 2000; 154(1): 237 - 246. [Abstract] [Full Text]
|
|
|
|
|
|
F. Relaix and M. Buckingham From insect eye to vertebrate muscle: redeployment of a regulatory network Genes & Dev., December 15, 1999; 13(24): 3171 - 3178. [Full Text]
|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
|
 |
|
 M. K. Jain, S. Kashiki, C.-M. Hsieh, M. D. Layne, S.-F. Yet, N. E. S. Sibinga, M. T. Chin, M. W. Feinberg, I. Woo, R. L. Maas, et al. Embryonic Expression Suggests an Important Role for CRP2/SmLIM in the Developing Cardiovascular System Circ. Res., November 16, 1998; 83(10): 980 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Eggert, B. Hauck, N. Hildebrandt, W. J. Gehring, and U. Walldorf Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development PNAS, March 3, 1998; 95(5): 2343 - 2348. [Abstract] [Full Text] [PDF]
|
|
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|
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N. Brown, S Kanekar, M. Vetter, P. Tucker, D. Gemza, and T Glaser Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis Development, January 12, 1998; 125(23): 4821 - 4833. [Abstract] [PDF]
|
|
|
|
|
|
M Bei and R Maas FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development Development, January 11, 1998; 125(21): 4325 - 4333. [Abstract] [PDF]
|
|
|
|
|
|
C. Zygar, T. Cook, and R. Grainger Gene activation during early stages of lens induction in Xenopus Development, January 9, 1998; 125(17): 3509 - 3519. [Abstract] [PDF]
|
|
|
|
|
|
M Kobayashi, R Toyama, H Takeda, I. Dawid, and K Kawakami Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish Development, January 8, 1998; 125(15): 2973 - 2982. [Abstract] [PDF]
|
|
|
|
|
|
G Halder, P Callaerts, S Flister, U Walldorf, U Kloter, and W. Gehring Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development Development, January 6, 1998; 125(12): 2181 - 2191. [Abstract] [PDF]
|
|
|
|
|
|
P.-X. Xu, J. Cheng, J. A. Epstein, and R. L. Maas Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function PNAS, October 28, 1997; 94(22): 11974 - 11979. [Abstract] [Full Text] [PDF]
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|
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 J E Zimmerman, Q T Bui, E Steingrimsson, D L Nagle, W Fu, A Genin, N B Spinner, N G Copeland, N A Jenkins, M Bucan, et al. Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res., February 1, 1997; 7(2): 128 - 141. [Abstract] [PDF]
|
|
|
|
|
|
N. Bonini, Q. Bui, G. Gray-Board, and J. Warrick The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates Development, January 12, 1997; 124(23): 4819 - 4826. [Abstract] [PDF]
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