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Development, Vol 124, Issue 11 2099-2117, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Fashioning the vertebrate heart: earliest embryonic decisions

MC Fishman and KR Chien
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA. fishman@cvrc.mgh.harvard.edu

Our goal here is to set out the types of unitary decisions made by heart progenitor cells, from their appearance in the heart field until they form the simple heart tube. This provides a context to evaluate cell fate, lineage and, finally, morphogenetic decisions that configure global heart form and function. Some paradigms for cellular differentiation and for pattern generation may be borrowed from invertebrates, but neither Drosophila nor Caenorhabditis elegans suffice to unravel higher order decisions. Genetic analyses in mouse and zebrafish may provide one entrance to these pathways.
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PNAS, January 19, 1999; 96(2): 547 - 551.
[Abstract] [Full Text] [PDF]

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R. Schwartz and E. Olson
Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription
Development, January 10, 1999; 126(19): 4187 - 4192.
[Abstract] [PDF]

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H Kuo, J Chen, P Ruiz-Lozano, Y Zou, M Nemer, and K. Chien
Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis
Development, January 10, 1999; 126(19): 4223 - 4234.
[Abstract] [PDF]

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T. Clark, S. Conway, I. Scott, P. Labosky, G Winnier, J Bundy, B. Hogan, and D. Greenspan
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart
Development, January 6, 1999; 126(12): 2631 - 2642.
[Abstract] [PDF]

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M Tanaka, S. Wechsler, I. Lee, N Yamasaki, J. Lawitts, and S Izumo
Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
Development, January 4, 1999; 126(7): 1439 - 1450.
[Abstract] [PDF]

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M. Horb and G. Thomsen
Tbx5 is essential for heart development
Development, January 4, 1999; 126(8): 1739 - 1751.
[Abstract] [PDF]

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M. Solloway and E. Robertson
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
Development, January 4, 1999; 126(8): 1753 - 1768.
[Abstract] [PDF]

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C Xu, G Liguori, M. Persico, and E. Adamson
Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes
Development, January 2, 1999; 126(3): 483 - 494.
[Abstract] [PDF]

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L Pardanaud and F Dieterlen-Lievre
Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo
Development, January 2, 1999; 126(4): 617 - 627.
[Abstract] [PDF]

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J. Reecy, X Li, M Yamada, F. DeMayo, C. Newman, R. Harvey, and R. Schwartz
Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5
Development, January 2, 1999; 126(4): 839 - 849.
[Abstract] [PDF]

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C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson
Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
Development, January 1, 1999; 126(1): 75 - 84.
[Abstract] [PDF]

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E. Kolossov, B.K. Fleischmann, Q. Liu, W. Bloch, S. Viatchenko-Karpinski, O. Manzke, G.J. Ji, H. Bohlen, K. Addicks, and J. Hescheler
Functional Characteristics of ES Cell-derived Cardiac Precursor Cells Identified by Tissue-specific Expression of the Green Fluorescent Protein
J. Cell Biol., December 28, 1998; 143(7): 2045 - 2056.
[Abstract] [Full Text] [PDF]

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I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton
Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells
J. Biol. Chem., December 25, 1998; 273(52): 34904 - 34910.
[Abstract] [Full Text] [PDF]

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H.S. Baldwin and M. Artman
Recent advances in cardiovascular development: promise for the future
Cardiovasc Res, December 1, 1998; 40(3): 456 - 468.
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J. Schott, D. W. Benson, C. T. Basson, W. Pease, G. M. Silberbach, J. P. Moak, B. J. Maron, C. E. Seidman, and J. G. Seidman
Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5
Science, July 3, 1998; 281(5373): 108 - 111.
[Abstract] [Full Text] [PDF]

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A. F.M. Moorman, F. de Jong, M. M.F.J. Denyn, and W. H. Lamers
Development of the Cardiac Conduction System
Circ. Res., April 6, 1998; 82(6): 629 - 644.
[Full Text] [PDF]

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P. Gruber, S. Kubalak, and K. Chien
Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos
Development, January 11, 1998; 125(22): 4427 - 4438.
[Abstract] [PDF]

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Y Fu, W Yan, T. Mohun, and S. Evans
Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner
Development, January 11, 1998; 125(22): 4439 - 4449.
[Abstract] [PDF]

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Q Lin, J Lu, H Yanagisawa, R Webb, G. Lyons, J. Richardson, and E. Olson
Requirement of the MADS-box transcription factor MEF2C for vascular development
Development, January 11, 1998; 125(22): 4565 - 4574.
[Abstract] [PDF]

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J. Chen, S. W. Kubalak, S. Minamisawa, R. L. Price, K. D. Becker, R. Hickey, J. Ross Jr., and K. R. Chien
Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function
J. Biol. Chem., January 9, 1998; 273(2): 1252 - 1256.
[Abstract] [Full Text] [PDF]

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R Creton, J. Speksnijder, and L. Jaffe
Patterns of free calcium in zebrafish embryos
J. Cell Sci., January 6, 1998; 111(12): 1613 - 1622.
[Abstract] [PDF]

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J. Kalb, K. Lau, B Goszczynski, T Fukushige, D Moons, P. Okkema, and J. McGhee
pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx
Development, January 6, 1998; 125(12): 2171 - 2180.
[Abstract] [PDF]

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J Chen, S. Kubalak, and K. Chien
Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis
Development, January 5, 1998; 125(10): 1943 - 1949.
[Abstract] [PDF]

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P Ruiz-Lozano, S. Smith, G Perkins, S. Kubalak, G. Boss, H. Sucov, R. Evans, and K. Chien
Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos
Development, January 2, 1998; 125(3): 533 - 544.
[Abstract] [PDF]

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P. Thomas, A Brown, and R. Beddington
Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
Development, January 1, 1998; 125(1): 85 - 94.
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J. Chen, F. van Eeden, K. Warren, A Chin, C Nusslein-Volhard, P Haffter, and M. Fishman
Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
Development, January 11, 1997; 124(21): 4373 - 4382.
[Abstract] [PDF]


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