|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 11 2119-2128, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
E Shishido, N Ono, T Kojima and K Saigo
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo-ku, Japan.
DFR1 encodes a mesoderm-specific fibroblast growth factor receptor in Drosophila. Here, we identified and characterized a protein-null mutant of DFR1 and examined DFR1 expression in embryos using anti-DFR1 antibody. Mutant phenotypes were completely rescued by a genomic fragment from the DFR1 locus. After invagination, mesodermal cells expressing DFR1 undergo proliferation and spread out dorsally to form a monolayer beneath the ectoderm. In mutant embryos, however, the mesoderm is not capable of extending to the normal dorsal limit and consequently mesodermal cells fail to receive ectodermal signals and thus rendered incapable of differentiating into primordia for the heart, visceral and somatic muscles. DFR1 is also required for normal development of the central nervous system. The absence of DFR1 resulted in the failure of longitudinal glia to enwrap longitudinal axon tracts. DFR1 mutant phenotypes were partially mimicked by the targeted expression of activated Yan, thus demonstrating the MAP kinase pathway to be involved in differentiation of mesoderm.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Klingseisen, I. B. N. Clark, T. Gryzik, and H.-A. J. Muller Differential and overlapping functions of two closely related Drosophila FGF8-like growth factors in mesoderm development Development, July 15, 2009; 136(14): 2393 - 2402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kadam, A. McMahon, P. Tzou, and A. Stathopoulos FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation Development, March 1, 2009; 136(5): 739 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. van Impel, S. Schumacher, M. Draga, H.-M. Herz, J. Grosshans, and H. A. J. Muller Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula Development, March 1, 2009; 136(5): 813 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Toledano-Katchalski, R. Nir, G. Volohonsky, and T. Volk Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading Development, October 1, 2007; 134(19): 3473 - 3481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Thomas and D. J. van Meyel The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression Development, February 1, 2007; 134(3): 591 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wilson, E. Vogelsang, and M. Leptin FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos Development, February 1, 2005; 132(3): 491 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Tseng, R. Shah, and M. Jamrich Function and regulation of FoxF1 during Xenopus gut development Development, August 1, 2004; 131(15): 3637 - 3647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schumacher, T. Gryzik, S. Tannebaum, and H.-A. J. Muller The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless Development, June 1, 2004; 131(11): 2631 - 2640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Smallhorn, M. J. Murray, and R. Saint The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble Development, June 1, 2004; 131(11): 2641 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wilson, A. Battersby, A. Csiszar, E. Vogelsang, and M. Leptin A Functional Domain of Dof That Is Required for Fibroblast Growth Factor Signaling Mol. Cell. Biol., March 15, 2004; 24(6): 2263 - 2276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stathopoulos, B. Tam, M. Ronshaugen, M. Frasch, and M. Levine pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos Genes & Dev., March 15, 2004; 18(6): 687 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Inlow and L. L. Restifo Molecular and Comparative Genetics of Mental Retardation Genetics, February 1, 2004; 166(2): 835 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Sepp and V. J. Auld Reciprocal Interactions between Neurons and Glia Are Required for Drosophila Peripheral Nervous System Development J. Neurosci., September 10, 2003; 23(23): 8221 - 8230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shandala, K. Takizawa, and R. Saint The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS Development, April 15, 2003; 130(8): 1505 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Egger, R. Leemans, T. Loop, L. Kammermeier, Y. Fan, T. Radimerski, M. C. Strahm, U. Certa, and H. Reichert Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system Development, March 9, 2003; 129(14): 3295 - 3309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Alsan and T. M. Schultheiss Regulation of avian cardiogenesis by Fgf8 signaling Development, March 6, 2003; 129(8): 1935 - 1943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Q. Gong and L. Li Dermo-1, a Multifunctional Basic Helix-Loop-Helix Protein, Represses MyoD Transactivation via the HLH Domain, MEF2 Interaction, and Chromatin Deacetylation J. Biol. Chem., March 29, 2002; 277(14): 12310 - 12317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dossenbach, S. Rock, and M. Affolter Specificity of FGF signaling in cell migration in Drosophila Development, November 15, 2001; 128(22): 4563 - 4572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Castanon, S. Von Stetina, J. Kass, and M. K. Baylies Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development Development, August 15, 2001; 128(16): 3145 - 3159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kinrade, T Brates, G Tear, and A Hidalgo Roundabout signalling, cell contact and trophic support confine longitudinal glia and axons in the Drosophila CNS Development, January 1, 2001; 128(2): 207 - 216. [Abstract] [PDF]
|
|
|
|
|
|
B San Martin and M Bate Hindgut visceral mesoderm requires an ectodermal template for normal development in Drosophila Development, January 1, 2001; 128(2): 233 - 242. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Fossett, Q. Zhang, K. Gajewski, C. Y. Choi, Y. Kim, and R. A. Schulz The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo PNAS, June 20, 2000; 97(13): 7348 - 7353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Suzuki and K Saigo Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus Development, January 4, 2000; 127(7): 1531 - 1540. [Abstract] [PDF]
|
|
|
|
|
|
A Hidalgo and G. Booth Glia dictate pioneer axon trajectories in the Drosophila embryonic CNS Development, January 1, 2000; 127(2): 393 - 402. [Abstract] [PDF]
|
|
|
|
|
|
F. Imam, D. Sutherland, W. Huang, and M. A. Krasnow stumps, a Drosophila Gene Required for Fibroblast Growth Factor (FGF)-directed Migrations of Tracheal and Mesodermal Cells Genetics, May 1, 1999; 152(1): 307 - 318. [Abstract] [Full Text]
|
|
|
|
|
|
K Gajewski, N Fossett, J. Molkentin, and R. Schulz The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila Development, January 12, 1999; 126(24): 5679 - 5688. [Abstract] [PDF]
|
|
|
|
|
|
B Condron Spatially discrete FGF-mediated signalling directs glial morphogenesis Development, January 10, 1999; 126(20): 4635 - 4641. [Abstract] [PDF]
|
|
|
|
|
|
X Lin, E. Buff, N Perrimon, and A. Michelson Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development Development, January 9, 1999; 126(17): 3715 - 3723. [Abstract] [PDF]
|
|
|
|
|
|
T Kusch and R Reuter Functions for Drosophila brachyenteron and forkhead in mesoderm specification and cell signalling Development, January 9, 1999; 126(18): 3991 - 4003. [Abstract] [PDF]
|
|
|
|
|
|
S Kramer, M Okabe, N Hacohen, M. Krasnow, and Y Hiromi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila Development, January 6, 1999; 126(11): 2515 - 2525. [Abstract] [PDF]
|
|
|
|
|
|
M. Su, M Fujioka, T Goto, and R Bodmer The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision Development, January 6, 1999; 126(14): 3241 - 3251. [Abstract] [PDF]
|
|
|
|
|
|
S Granderath, A Stollewerk, S Greig, C. Goodman, C. O'Kane, and C Klambt loco encodes an RGS protein required for Drosophila glial differentiation Development, January 4, 1999; 126(8): 1781 - 1791. [Abstract] [PDF]
|
|
|
|
|
|
A. Carmena, S. Gisselbrecht, J. Harrison, F. Jiménez, and A. M. Michelson Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm Genes & Dev., December 15, 1998; 12(24): 3910 - 3922. [Abstract] [Full Text]
|
|
|
|
|
|
B. D. Harfe, A. V. Gomes, C. Kenyon, J. Liu, M. Krause, and A. Fire Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning Genes & Dev., August 15, 1998; 12(16): 2623 - 2635. [Abstract] [Full Text]
|
|
|
|
|
|
A. Michelson, S Gisselbrecht, E Buff, and J. Skeath Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila Development, January 11, 1998; 125(22): 4379 - 4389. [Abstract] [PDF]
|
|
|
|
|
|
E Buff, A Carmena, S Gisselbrecht, F Jimenez, and A. Michelson Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors Development, January 6, 1998; 125(11): 2075 - 2086. [Abstract] [PDF]
|
|
