|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 11 2155-2165, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
G Struhl, DA Barbash and PA Lawrence
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. struhl@cuccfa.ccc.columbia.edu
The epidermis of the adult Drosophila abdomen is formed by a chain of anterior (A) and posterior (P) compartments, each segment comprising one A and one P compartment. In the accompanying paper (Struhl et al., 1997), we provide evidence that Hedgehog protein (Hh), being secreted from P compartment cells, organises the pattern and polarity of A compartment cells. Here we test whether Hh acts directly or by a signal relay mechanism. We use mutations in Protein Kinase A (PKA) or smoothened (smo) to activate or to block Hh signal transduction in clones of A compartment cells. For cell type, a scalar property, both manipulations cause strictly autonomous transformations: the cells affected are exactly those and only those that are mutant. Hence, we infer that Hh acts directly on A compartment cells to specify the various types of cuticular structures that they differentiate. By contrast, these same manipulations cause non-autonomous effects on cell polarity, a vectorial property. Consequently, we surmise that Hh influences cell polarity indirectly, possibly by inducing other signalling factors. Finally, we present evidence that Hh does not polarise abdominal cells by utilising either Decapentaplegic (Dpp) or Wingless (Wg), the two morphogens through which Hh acts during limb development. We conclude that, in the abdomen, cell type and cell polarity reflect distinct outputs of Hh signalling and propose that these outputs are controlled by separable gradient and signal relay mechanisms.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Strutt Gradients and the Specification of Planar Polarity in the Insect Cuticle Cold Spring Harb Perspect Biol, November 1, 2009; 1(5): a000489 - a000489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dickey, C. Kraft, U. Jinwal, J. Koren, A. Johnson, L. Anderson, L. Lebson, D. Lee, D. Dickson, R. de Silva, et al. Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy Am. J. Pathol., January 1, 2009; 174(1): 228 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ratan, D. A. Mason, B. Sinnot, D. S. Goldfarb, and R. J. Fleming Drosophila Importin {alpha}1 Performs Paralog-Specific Functions Essential For Gametogenesis Genetics, February 1, 2008; 178(2): 839 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Casal, P. A. Lawrence, and G. Struhl Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development, November 1, 2006; 133(22): 4561 - 4572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Price, D. M. Roberts, B. M. McCartney, E. Jezuit, and M. Peifer Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle J. Cell Sci., February 1, 2006; 119(3): 403 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Zeltser Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon Development, May 1, 2005; 132(9): 2023 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Amonlirdviman, N. A. Khare, D. R. P. Tree, W.-S. Chen, J. D. Axelrod, and C. J. Tomlin Mathematical Modeling of Planar Cell Polarity to Understand Domineering Nonautonomy Science, January 21, 2005; 307(5708): 423 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Lawrence, J. Casal, and G. Struhl Cell interactions and planar polarity in the abdominal epidermis of Drosophila Development, October 1, 2004; 131(19): 4651 - 4664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Han, T. Y. Belenkaya, B. Wang, and X. Lin Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process Development, February 1, 2004; 131(3): 601 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hammond, H. E. Loynes, A. A. Folarin, J. Smith, and T. T. Whitfield Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle Development, April 1, 2003; 130(7): 1403 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Micchelli, I. The, E. Selva, V. Mogila, and N. Perrimon rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling Development, March 4, 2003; 129(4): 843 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gorfinkiel, L. Sanchez, and I. Guerrero Development of the Drosophila genital disc requires interactions between its segmental primordia Development, March 2, 2003; 130(2): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Lawrence, J. Casal, and G. Struhl Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen Development, January 6, 2002; 129(11): 2749 - 2760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Extavour and A. Garcia-Bellido Germ cell selection in genetic mosaics in Drosophila melanogaster PNAS, September 25, 2001; 98(20): 11341 - 11346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Day and P. Lawrence Measuring dimensions: the regulation of size and shape Development, January 7, 2000; 127(14): 2977 - 2987. [Abstract] [PDF]
|
|
|
|
|
|
A Tomlinson and G Struhl Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye Development, January 12, 1999; 126(24): 5725 - 5738. [Abstract] [PDF]
|
|
|
|
|
|
S Greenwood and G Struhl Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway Development, January 12, 1999; 126(24): 5795 - 5808. [Abstract] [PDF]
|
|
|
|
|
|
A Kopp, R. Blackman, and I Duncan Wingless, decapentaplegic and EGF receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila Development, January 8, 1999; 126(16): 3495 - 3507. [Abstract] [PDF]
|
|
|
|
|
|
K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway Development, January 6, 1999; 126(11): 2397 - 2407. [Abstract] [PDF]
|
|
|
|
|
|
P. Lawrence, J Casal, and G Struhl hedgehog and engrailed: pattern formation and polarity in the Drosophila abdomen Development, January 6, 1999; 126(11): 2431 - 2439. [Abstract] [PDF]
|
|
|
|
|
|
P. Lawrence, J Casal, and G Struhl The hedgehog morphogen and gradients of cell affinity in the abdomen of Drosophila Development, January 6, 1999; 126(11): 2441 - 2449. [Abstract] [PDF]
|
|
|
|
|
|
J. Taylor, N. Abramova, J. Charlton, and P. N. Adler Van Gogh: A New Drosophila Tissue Polarity Gene Genetics, September 1, 1998; 150(1): 199 - 210. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. T. Ohlmeyer and D. Kalderon Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos Genes & Dev., September 1, 1997; 11(17): 2250 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Tomlinson, W. Strapps, and J Heemskerk Linking Frizzled and Wnt signaling in Drosophila development Development, January 11, 1997; 124(22): 4515 - 4521. [Abstract] [PDF]
|
|
|
|
|
|
M Strigini and S. Cohen A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing Development, January 11, 1997; 124(22): 4697 - 4705. [Abstract] [PDF]
|
|
|
|
|
|
A Kopp, M. Muskavitch, and I Duncan The roles of hedgehog and engrailed in patterning adult abdominal segments of Drosophila Development, January 10, 1997; 124(19): 3703 - 3714. [Abstract] [PDF]
|
|
|
|
|
|
A Kopp and I Duncan Control of cell fate and polarity in the adult abdominal segments of Drosophila by optomotor-blind Development, January 10, 1997; 124(19): 3715 - 3726. [Abstract] [PDF]
|
|
