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Development, Vol 124, Issue 11 2203-2212, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Y Furuta, DW Piston and BL Hogan
Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-2175, USA.

Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of developmental processes, but their functions during early vertebrate brain development are largely unknown. To investigate this problem, we have compared by in situ hybridization the expression of five Bmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7). Striking co-expression of these Bmps is observed within the dorsomedial telencephalon, coincident with a future site of choroid plexus development. Bmp co-expression overlaps that of Msx1 and Hfh4, and is complementary to that of Bf1. The domain of Bmp co-expression is also associated with limited growth of the neuroectoderm, as revealed by morphological observation, reduced cell proliferation, and increased local programmed cell death. In vitro experiments using explants from the embryonic lateral telencephalic neuroectoderm reveal that exogenous BMP proteins (BMP4 and BMP2) induce expression of Msx1 and inhibit Bf1 expression, a finding consistent with their specific expression patterns in vivo. Moreover, BMP proteins locally inhibit cell proliferation and increase apoptosis in the explants. These results provide evidence that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death.
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R. Yamada, Y. Mizutani-Koseki, T. Hasegawa, N. Osumi, H. Koseki, and N. Takahashi
Cell-autonomous involvement of Mab21l1 is essential for lens placode development
Development, May 1, 2003; 130(9): 1759 - 1770.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. Garel, K. J. Huffman, and J. L. R. Rubenstein
Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants
Development, May 1, 2003; 130(9): 1903 - 1914.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
M. Ishibashi and A. P. McMahon
A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo
Development, March 12, 2003; 129(20): 4807 - 4819.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
P. Ybot-Gonzalez, P. Cogram, D. Gerrelli, and A. J. Copp
Sonic hedgehog and the molecular regulation of mouse neural tube closure
Development, March 7, 2003; 129(10): 2507 - 2517.
[Abstract] [Full Text] [PDF]

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 CarcinogenesisHome page
N. V. Popova, K. A. Teti, K. Q. Wu, and R. J. Morris
Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis
Carcinogenesis, March 1, 2003; 24(3): 417 - 425.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
E. E. Storm, J. L. R. Rubenstein, and G. R. Martin
Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain
PNAS, February 18, 2003; 100(4): 1757 - 1762.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
K. M. Bishop, J. L. R. Rubenstein, and D. D. M. O'Leary
Distinct Actions of Emx1, Emx2, and Pax6 in Regulating the Specification of Areas in the Developing Neocortex
J. Neurosci., September 1, 2002; 22(17): 7627 - 7638.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
K. Dumstrei, F. Wang, D. Shy, U. Tepass, and V. Hartenstein
Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis
Development, September 1, 2002; 129(17): 3983 - 3994.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
C. Hanashima, L. Shen, S. C. Li, and E. Lai
Brain Factor-1 Controls the Proliferation and Differentiation of Neocortical Progenitor Cells through Independent Mechanisms
J. Neurosci., August 1, 2002; 22(15): 6526 - 6536.
[Abstract] [Full Text] [PDF]

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 JEMHome page
D. Graf, S. Nethisinghe, D. B. Palmer, A. G. Fisher, and M. Merkenschlager
The Developmentally Regulated Expression of Twisted Gastrulation Reveals a Role for Bone Morphogenetic Proteins in the Control of T Cell Development
J. Exp. Med., July 15, 2002; 196(2): 163 - 171.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
L. A. Martin, S.-S. Tan, and D. Goldowitz
Clonal Architecture of the Mouse Hippocampus
J. Neurosci., May 1, 2002; 22(9): 3520 - 3530.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
G. Lupo, W. A. Harris, G. Barsacchi, and R. Vignali
Induction and patterning of the telencephalon in Xenopus laevis
Development, January 12, 2002; 129(23): 5421 - 5436.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
R. M. Anderson, A. R. Lawrence, R. W. Stottmann, D. Bachiller, and J. Klingensmith
Chordin and noggin promote organizing centers of forebrain development in the mouse
Development, January 11, 2002; 129(21): 4975 - 4987.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
S. Zhao, Q. Chen, F.-C. Hung, and P. A. Overbeek
BMP signaling is required for development of the ciliary body
Development, January 10, 2002; 129(19): 4435 - 4442.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
T. Theil, S. Aydin, S. Koch, L. Grotewold, and U. Ruther
Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon
Development, January 7, 2002; 129(13): 3045 - 3054.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
D. M. Panchision, J. M. Pickel, L. Studer, S.-H. Lee, P. A. Turner, T. G. Hazel, and R. D.G. McKay
Sequential actions of BMP receptors control neural precursor cell production and fate
Genes & Dev., August 15, 2001; 15(16): 2094 - 2110.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
Y. Ying, X. Qi, and G.-Q. Zhao
Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways
PNAS, June 20, 2001; (2001) 151242798.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
T. R. Clarke, Y. Hoshiya, S. E. Yi, X. Liu, K. M. Lyons, and P. K. Donahoe
Mullerian Inhibiting Substance Signaling Uses a Bone Morphogenetic Protein (BMP)-Like Pathway Mediated by ALK2 and Induces Smad6 Expression
Mol. Endocrinol., June 1, 2001; 15(6): 946 - 959.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
S. Tole and E. A. Grove
Detailed Field Pattern Is Intrinsic to the Embryonic Mouse Hippocampus Early in Neurogenesis
J. Neurosci., March 1, 2001; 21(5): 1580 - 1589.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
F. Trousse, P. Esteve, and P. Bovolenta
BMP4 Mediates Apoptotic Cell Death in the Developing Chick Eye
J. Neurosci., February 15, 2001; 21(4): 1292 - 1301.
[Abstract] [Full Text] [PDF]

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 J. Histochem. Cytochem.Home page
N. Miao, B. Fung, R. Sanchez, J. Lydon, D. Barker, and K. Pang
Isolation and Expression of PASK, a Serine/Threonine Kinase, During Rat Embryonic Development, with Special Emphasis on the Pancreas
J. Histochem. Cytochem., October 1, 2000; 48(10): 1391 - 1400.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
C. Dou, J. Lee, B. Liu, F. Liu, J. Massague, S. Xuan, and E. Lai
BF-1 Interferes with Transforming Growth Factor beta Signaling by Associating with Smad Partners
Mol. Cell. Biol., September 1, 2000; 20(17): 6201 - 6211.
[Abstract] [Full Text]

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 J. Neurosci.Home page
S. I. Savitz and J. A. Kessler
Leukemia Inhibitory Factor Requires Concurrent p75LNTR Signaling to Induce Apoptosis of Cultured Sympathetic Neurons
J. Neurosci., June 1, 2000; 20(11): 4198 - 4205.
[Abstract] [Full Text] [PDF]

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 Hum Mol GenetHome page
R. S. Smith, A. Zabaleta, T. Kume, O. V. Savinova, S. H. Kidson, J. E. Martin, D. Y. Nishimura, W. L. M. Alward, B. L. M. Hogan, and S. W. M. John
Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development
Hum. Mol. Genet., April 12, 2000; 9(7): 1021 - 1032.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
S. Tole, G. Goudreau, S. Assimacopoulos, and E. A. Grove
Emx2 Is Required for Growth of the Hippocampus But Not for Hippocampal Field Specification
J. Neurosci., April 1, 2000; 20(7): 2618 - 2625.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
J Shou, R. Murray, P. Rim, and A. Calof
Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage
Development, January 12, 2000; 127(24): 5403 - 5413.
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L Lillien and H Raphael
BMP and FGF regulate the development of EGF-responsive neural progenitor cells
Development, January 11, 2000; 127(22): 4993 - 5005.
[Abstract] [PDF]


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