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Development, Vol 124, Issue 11 2235-2244, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

H Ohuchi, T Nakagawa, A Yamamoto, A Araga, T Ohata, Y Ishimaru, H Yoshioka, T Kuwana, T Nohno, M Yamasaki, N Itoh and S Noji
Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Japan.

Vertebrate limb formation has been known to be initiated by a factor(s) secreted from the lateral plate mesoderm. In this report, we provide evidence that a member of the fibroblast growth factor (FGF) family, FGF10, emanates from the prospective limb mesoderm to serve as an endogenous initiator for limb bud formation. Fgf10 expression in the prospective limb mesenchyme precedes Fgf8 expression in the nascent apical ectoderm. Ectopic application of FGF10 to the chick embryonic flank can induce Fgf8 expression in the adjacent ectoderm, resulting in the formation of an additional complete limb. Expression of Fgf10 persists in the mesenchyme of the established limb bud and appears to interact with Fgf8 in the apical ectoderm and Sonic hedgehog in the zone of polarizing activity. These results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs.
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 DevelopmentHome page
M Logan, H. Simon, and C Tabin
Differential regulation of T-box and homeobox transcription factors suggests roles in controlling chick limb-type identity
Development, January 8, 1998; 125(15): 2825 - 2835.
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F Reifers, H Bohli, E. Walsh, P. Crossley, D. Stainier, and M Brand
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
Development, January 7, 1998; 125(13): 2381 - 2395.
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J. Gibson-Brown, S. Agulnik, L. Silver, L Niswander, and V. Papaioannou
Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development
Development, January 7, 1998; 125(13): 2499 - 2509.
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 DevelopmentHome page
M Grigoriou, A. Tucker, P. Sharpe, and V Pachnis
Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development
Development, January 6, 1998; 125(11): 2063 - 2074.
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 DevelopmentHome page
M Ensini, T. Tsuchida, H. Belting, and T. Jessell
The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm
Development, January 3, 1998; 125(6): 969 - 982.
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X Xu, M Weinstein, C Li, M Naski, R. Cohen, D. Ornitz, P Leder, and C Deng
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
Development, January 2, 1998; 125(4): 753 - 765.
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H Ohuchi, J Takeuchi, H Yoshioka, Y Ishimaru, K Ogura, N Takahashi, T Ogura, and S Noji
Correlation of wing-leg identity in ectopic FGF-induced chimeric limbs with the differential expression of chick Tbx5 and Tbx4
Development, January 1, 1998; 125(1): 51 - 60.
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 J. Biol. Chem.Home page
H. Emoto, S. Tagashira, M.-G. Mattei, M. Yamasaki, G. Hashimoto, T. Katsumata, T. Negoro, M. Nakatsuka, D. Birnbaum, F. Coulier, et al.
Structure and Expression of Human Fibroblast Growth Factor-10
J. Biol. Chem., September 12, 1997; 272(37): 23191 - 23194.
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S Bellusci, J Grindley, H Emoto, N Itoh, and B. Hogan
Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
Development, January 12, 1997; 124(23): 4867 - 4878.
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M Altabef, J. Clarke, and C Tickle
Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb
Development, January 11, 1997; 124(22): 4547 - 4556.
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 Cold Spring Harb Symp Quant BiolHome page
M. Lewandoski, E.N. Meyers, and G.R. Martin
Analysis of Fgf8 Gene Function in Vertebrate Development
Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 159 - 168.
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