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Development, Vol 124, Issue 13 2659-2670, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes

LP Sanford, I Ormsby, AC Gittenberger-de Groot, H Sariola, R Friedman, GP Boivin, EL Cardell and T Doetschman
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, OH 45267, USA.

The growth and differentiation factor transforming growth factor-beta2 (TGFbeta2) is thought to play important roles in multiple developmental processes. Targeted disruption of the TGFbeta2 gene was undertaken to determine its essential role in vivo. TGFbeta2-null mice exhibit perinatal mortality and a wide range of developmental defects for a single gene disruption. These include cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital defects. The developmental processes most commonly involved in the affected tissues include epithelial-mesenchymal interactions, cell growth, extracellular matrix production and tissue remodeling. In addition, many affected tissues have neural crest-derived components and simulate neural crest deficiencies. There is no phenotypic overlap with TGFbeta1- and TGFbeta3-null mice indicating numerous non-compensated functions between the TGFbeta isoforms.
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Home page
 Clin. Cancer Res.Home page
R. S. Muraoka-Cook, N. Dumont, and C. L. Arteaga
Dual Role of Transforming Growth Factor ss in Mammary Tumorigenesis and Metastatic Progression
Clin. Cancer Res., January 15, 2005; 11(2): 937s - 943s.
[Abstract] [Full Text] [PDF]

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 Hum Exp ToxicolHome page
R. M Greene and M M. Pisano
Recent advances in understanding transforming growth factor {beta} regulation of orofacial development
Human and Experimental Toxicology, January 1, 2005; 24(1): 1 - 12.
[Abstract] [PDF]

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 PhysiologyHome page
R. V. Sampogna and S. K. Nigam
Implications of Gene Networks for Understanding Resilience and Vulnerability in the Kidney Branching Program
Physiology, December 1, 2004; 19(6): 339 - 347.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
D. G.M. Molin, R. E. Poelmann, M. C. DeRuiter, M. Azhar, T. Doetschman, and A. C. Gittenberger-de Groot
Transforming Growth Factor {beta}-SMAD2 Signaling Regulates Aortic Arch Innervation and Development
Circ. Res., November 26, 2004; 95(11): 1109 - 1117.
[Abstract] [Full Text] [PDF]

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 CROBMHome page
S.S. Prime, M. Pring, M. Davies, and I.C. Paterson
TGF-{beta} SIGNAL TRANSDUCTION IN ORO-FACIAL HEALTH AND NON-MALIGNANT DISEASE (PART I)
Critical Reviews in Oral Biology & Medicine, November 1, 2004; 15(6): 324 - 336.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
H. W. Chu, S. Balzar, G. J. Seedorf, J. Y. Westcott, J. B. Trudeau, P. Silkoff, and S. E. Wenzel
Transforming Growth Factor-{beta}2 Induces Bronchial Epithelial Mucin Expression in Asthma
Am. J. Pathol., October 1, 2004; 165(4): 1097 - 1106.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
L. Oxburgh, G. C. Chu, S. K. Michael, and E. J. Robertson
TGF{beta} superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population
Development, September 15, 2004; 131(18): 4593 - 4605.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
D. Tomic, K. P. Miller, H. A. Kenny, T. K. Woodruff, P. Hoyer, and J. A. Flaws
Ovarian Follicle Development Requires Smad3
Mol. Endocrinol., September 1, 2004; 18(9): 2224 - 2240.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
E. Sock, S. D. Rettig, J. Enderich, M. R. Bosl, E. R. Tamm, and M. Wegner
Gene Targeting Reveals a Widespread Role for the High-Mobility-Group Transcription Factor Sox11 in Tissue Remodeling
Mol. Cell. Biol., August 1, 2004; 24(15): 6635 - 6644.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
V. Kaartinen, M. Dudas, A. Nagy, S. Sridurongrit, M. M. Lu, and J. A. Epstein
Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
Development, July 15, 2004; 131(14): 3481 - 3490.
[Abstract] [Full Text] [PDF]

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 Cereb CortexHome page
J. A. Siegenthaler and M. W. Miller
Transforming Growth Factor {beta}1 Modulates Cell Migration in Rat Cortex: Effects of Ethanol
Cereb Cortex, July 1, 2004; 14(7): 791 - 802.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
Y. Lan, C. E. Ovitt, E.-S. Cho, K. M. Maltby, Q. Wang, and R. Jiang
Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis
Development, July 1, 2004; 131(13): 3207 - 3216.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
I. S. McLennan and K. Koishi
Fetal and Maternal Transforming Growth Factor-{beta}1 May Combine to Maintain Pregnancy in Mice
Biol Reprod, June 1, 2004; 70(6): 1614 - 1618.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. del Re, J. L. Babitt, A. Pirani, A. L. Schneyer, and H. Y. Lin
In the Absence of Type III Receptor, the Transforming Growth Factor (TGF)-{beta} Type II-B Receptor Requires the Type I Receptor to Bind TGF-{beta}2
J. Biol. Chem., May 21, 2004; 279(21): 22765 - 22772.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
M. M. Shah, R. V. Sampogna, H. Sakurai, K. T. Bush, and S. K. Nigam
Branching morphogenesis and kidney disease
Development, April 1, 2004; 131(7): 1449 - 1462.
[Abstract] [Full Text] [PDF]

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 Hum Mol GenetHome page
P. Stanier and G. E. Moore
Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts
Hum. Mol. Genet., April 1, 2004; 13(suppl_1): R73 - R81.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
C. Oka, R. Tsujimoto, M. Kajikawa, K. Koshiba-Takeuchi, J. Ina, M. Yano, A. Tsuchiya, Y. Ueta, A. Soma, H. Kanda, et al.
HtrA1 serine protease inhibits signaling mediated by Tgf{beta} family proteins
Development, March 1, 2004; 131(5): 1041 - 1053.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
P. J. Gruber and J. A. Epstein
Development Gone Awry: Congenital Heart Disease
Circ. Res., February 20, 2004; 94(3): 273 - 283.
[Abstract] [Full Text] [PDF]

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 ChestHome page
U. Bartram and C. P. Speer
The Role of Transforming Growth Factor {beta} in Lung Development and Disease
Chest, February 1, 2004; 125(2): 754 - 765.
[Abstract] [Full Text] [PDF]

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 JEMHome page
J. C. Langer, E. Henckaerts, J. Orenstein, and H.-W. Snoeck
Quantitative Trait Analysis Reveals Transforming Growth Factor-{beta}2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function
J. Exp. Med., January 5, 2004; 199(1): 5 - 14.
[Abstract] [Full Text] [PDF]

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 JCBHome page
M. Hyytiainen and J. Keski-Oja
Latent TGF-{beta} binding protein LTBP-2 decreases fibroblast adhesion to fibronectin
J. Cell Biol., December 22, 2003; 163(6): 1363 - 1374.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
Y. Ito, J. Y. Yeo, A. Chytil, J. Han, P. Bringas Jr, A. Nakajima, C. F. Shuler, H. L. Moses, and Y. Chai
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
Development, November 1, 2003; 130(21): 5269 - 5280.
[Abstract] [Full Text] [PDF]

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 Nucleic Acids ResHome page
Y.-S. Kim, G. Nakanishi, M. Lewandoski, and A. M. Jetten
GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions
Nucleic Acids Res., October 1, 2003; 31(19): 5513 - 5525.
[Abstract] [Full Text] [PDF]

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 IOVSHome page
B. M. Stramer, J. D. Zieske, J.-C. Jung, J. S. Austin, and M. E. Fini
Molecular Mechanisms Controlling the Fibrotic Repair Phenotype in Cornea: Implications for Surgical Outcomes
Invest. Ophthalmol. Vis. Sci., October 1, 2003; 44(10): 4237 - 4246.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
C. Daniel, Y. Takabatake, M. Mizui, Y. Isaka, H. Kawashi, H. Rupprecht, E. Imai, and C. Hugo
Antisense Oligonucleotides Against Thrombospondin-1 Inhibit Activation of TGF-{beta} in Fibrotic Renal Disease in the Rat in Vivo
Am. J. Pathol., September 1, 2003; 163(3): 1185 - 1192.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
K. L. Stenvers, M. L. Tursky, K. W. Harder, N. Kountouri, S. Amatayakul-Chantler, D. Grail, C. Small, R. A. Weinberg, A. M. Sizeland, and H.-J. Zhu
Heart and Liver Defects and Reduced Transforming Growth Factor {beta}2 Sensitivity in Transforming Growth Factor {beta} Type III Receptor-Deficient Embryos
Mol. Cell. Biol., June 15, 2003; 23(12): 4371 - 4385.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
L. M. Farkas, N. Dunker, E. Roussa, K. Unsicker, and K. Krieglstein
Transforming Growth Factor-{beta}s Are Essential for the Development of Midbrain Dopaminergic Neurons In Vitro and In Vivo
J. Neurosci., June 15, 2003; 23(12): 5178 - 5186.
[Abstract] [Full Text] [PDF]

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 CROBMHome page
T. Thyagarajan, S. Totey, M. J. S. Danton, and A. B. Kulkarni
GENETICALLY ALTERED MOUSE MODELS: THE GOOD, THE BAD, AND THE UGLY
Critical Reviews in Oral Biology & Medicine, May 1, 2003; 14(3): 154 - 174.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
R. Bommireddy, V. Saxena, I. Ormsby, M. Yin, G. P. Boivin, G. F. Babcock, R. R. Singh, and T. Doetschman
TGF-{beta}1 Regulates Lymphocyte Homeostasis by Preventing Activation and Subsequent Apoptosis of Peripheral Lymphocytes
J. Immunol., May 1, 2003; 170(9): 4612 - 4622.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
R. Bommireddy, I. Ormsby, M. Yin, G. P. Boivin, G. F. Babcock, and T. Doetschman
TGF{beta}1 Inhibits Ca2+-Calcineurin-Mediated Activation in Thymocytes
J. Immunol., April 1, 2003; 170(7): 3645 - 3652.
[Abstract] [Full Text] [PDF]


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