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Development, Vol 124, Issue 13 2659-2670, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
LP Sanford, I Ormsby, AC Gittenberger-de Groot, H Sariola, R Friedman, GP Boivin, EL Cardell and T Doetschman
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, OH 45267, USA.
The growth and differentiation factor transforming growth factor-beta2 (TGFbeta2) is thought to play important roles in multiple developmental processes. Targeted disruption of the TGFbeta2 gene was undertaken to determine its essential role in vivo. TGFbeta2-null mice exhibit perinatal mortality and a wide range of developmental defects for a single gene disruption. These include cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital defects. The developmental processes most commonly involved in the affected tissues include epithelial-mesenchymal interactions, cell growth, extracellular matrix production and tissue remodeling. In addition, many affected tissues have neural crest-derived components and simulate neural crest deficiencies. There is no phenotypic overlap with TGFbeta1- and TGFbeta3-null mice indicating numerous non-compensated functions between the TGFbeta isoforms.
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