|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 14 2681-2690, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
K Luer, J Urban, C Klambt and GM Technau
Institut fur Genetik, Universitat Mainz, Germany.
The Drosophila ventral midline cells generate a discrete set of CNS lineages, required for proper patterning of the ventral ectoderm. Here we provide the first evidence that the CNS midline cells also exert inductive effects on the mesoderm. Mesodermal progenitors adjacent to the midline progenitor cells give rise to ventral somatic mucles and a pair of unique cells that come to lie dorsomedially on top of the ventral nerve cord, the so-called DM cells. Cell ablation as well as cell transplantation experiments indicate that formation of the DM cells is induced by midline progenitors in the early embryo. These results are corroborated by genetic analyses. Mutant single minded embryos lack the CNS midline as well as the DM cells. Embryos mutant for any of the spitz group genes, which primarily express defects in the midline glial cell lineages, show reduced formation of the DM cells. Conversely, directed overexpression of secreted SPITZ by some or all CNS midline cells leads to the formation of additional DM cells. Furthermore we show that DM cell development does not depend on the absolute concentration of a local inductor but appears to require a graded source of an inducing signal. Thus, the Drosophila CNS midline cells play a central inductive role in patterning the mesoderm as well as the underlying ectoderm.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Bossing and A. H. Brand Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline Development, March 15, 2006; 133(6): 1001 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Dettman, F. R. Turner, H. D. Hoyle, and E. C. Raff Embryonic Expression of the Divergent Drosophila {beta}3-Tubulin Isoform Is Required for Larval Behavior Genetics, May 1, 2001; 158(1): 253 - 263. [Abstract] [Full Text]
|
|
|
|
|
|
B San Martin and M Bate Hindgut visceral mesoderm requires an ectodermal template for normal development in Drosophila Development, January 1, 2001; 128(2): 233 - 242. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Carmena, S. Gisselbrecht, J. Harrison, F. Jiménez, and A. M. Michelson Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm Genes & Dev., December 15, 1998; 12(24): 3910 - 3922. [Abstract] [Full Text]
|
|
|
|
|
|
S. T. Crews Control of cell lineage-specific development and transcription by bHLH-PAS proteins Genes & Dev., March 1, 1998; 12(5): 607 - 620. [Full Text]
|
|
|
|
|
|
G Udolph, J Urban, G Rusing, K Luer, and G. Technau Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS Development, January 9, 1998; 125(17): 3291 - 3299. [Abstract] [PDF]
|
|
|
|
|
|
V Riechmann, K. Rehorn, R Reuter, and M Leptin The genetic control of the distinction between fat body and gonadal mesoderm in Drosophila Development, January 2, 1998; 125(4): 713 - 723. [Abstract] [PDF]
|
|
