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Development, Vol 124, Issue 14 2691-2700, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
P Soriano
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. psoriano@fhcrc.org
Platelet-derived growth factors (PDGFs) have been implicated in the control of cell proliferation, survival and migration. Patch mutant mice harbor a deletion including the PDGF alpha receptor gene and exhibit defects of neural crest origin which affect pigmentation in heterozygotes and cranial bones in homozygotes. To verify the role of the PDGF alphaR gene during development, mice carrying a targeted null mutation were generated. No pigmentation phenotype was observed in heterozygotes. Homozygotes die during embryonic development and exhibit incomplete cephalic closure similar to that observed in a subset of Patch mutants. In addition, increased apoptosis was observed on pathways followed by migrating neural crest cells. However, alterations in mutant vertebrae, ribs and sternum were also observed, which appear to stem from a deficiency in myotome formation. These results indicate that PDGFs may exert their functions during early embryogenesis by affecting cell survival and patterning.
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L Karlsson, C Bondjers, and C Betsholtz Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle Development, January 6, 1999; 126(12): 2611 - 2621. [Abstract] [PDF]
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M Tanaka, Z Chen, S Bartunkova, N Yamasaki, and S Izumo The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development Development, January 3, 1999; 126(6): 1269 - 1280. [Abstract] [PDF]
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G.Y. Huang, E.S. Cooper, K. Waldo, M.L. Kirby, N.B. Gilula, and C.W. Lo Gap Junction-mediated Cell-Cell Communication Modulates Mouse Neural Crest Migration J. Cell Biol., December 14, 1998; 143(6): 1725 - 1734. [Abstract] [Full Text] [PDF]
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P. H. L. J. Joosten, F. A. Hol, S. E. C. van Beersum, H. Peters, B. C. J. Hamel, G. B. Afink, E. J. J. van Zoelen, and E. C. M. Mariman Altered regulation of platelet-derived growth factor receptor-alpha gene-transcription in vitro by spina bifida-associated mutant Pax1 proteins PNAS, November 24, 1998; 95(24): 14459 - 14463. [Abstract] [Full Text] [PDF]
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L. Chin, G. Merlino, and R. A. DePinho Malignant melanoma: modern black plague and genetic black box Genes & Dev., November 15, 1998; 12(22): 3467 - 3481. [Full Text]
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R. B. Hough, A. Lengeling, V. Bedian, C. Lo, and M. Bucan Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression PNAS, November 10, 1998; 95(23): 13800 - 13805. [Abstract] [Full Text] [PDF]
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J. A. Epstein, B. Song, M. Lakkis, and C. Wang Tumor-Specific PAX3-FKHR Transcription Factor, but Not PAX3, Activates the Platelet-Derived Growth Factor Alpha Receptor Mol. Cell. Biol., July 1, 1998; 18(7): 4118 - 4130. [Abstract] [Full Text]
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C. Baudoin, M.-J. Goumans, C. Mummery, and A. Sonnenberg Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development Genes & Dev., April 15, 1998; 12(8): 1202 - 1216. [Abstract] [Full Text]
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M. Lakkis and J. Epstein Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart Development, January 11, 1998; 125(22): 4359 - 4367. [Abstract] [PDF]
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K. Griffin, S. Amacher, C. Kimmel, and D Kimelman Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes Development, January 9, 1998; 125(17): 3379 - 3388. [Abstract] [PDF]
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R Hooshmand-Rad, K Yokote, C. Heldin, and L Claesson-Welsh PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells J. Cell Sci., January 3, 1998; 111(5): 607 - 614. [Abstract] [PDF]
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P Lindahl, L Karlsson, M Hellstrom, S Gebre-Medhin, K Willetts, J. Heath, and C Betsholtz Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development Development, January 10, 1997; 124(20): 3943 - 3953. [Abstract] [PDF]
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J. Yu, T. F. Deuel, and H.-R. C. Kim Platelet-derived Growth Factor (PDGF) Receptor-alpha Activates c-Jun NH2-terminal Kinase-1 and Antagonizes PDGF Receptor-beta -induced Phenotypic Transformation J. Biol. Chem., June 16, 2000; 275(25): 19076 - 19082. [Abstract] [Full Text] [PDF]
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