|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 16 3037-3044, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
A Suzuki, N Ueno and A Hemmati-Brivanlou
Laboratory of Molecular Embryology, The Rockefeller University, New York, NY 10021-6399, USA.
Epidermal fate in Xenopus ectoderm has been shown to be induced by a secreted growth factor, Bone Morphogenetic Protein 4 (BMP4). However, the molecular mechanism mediating this response is poorly understood. Here, we show that the expression of the homeobox gene, msx1, is an immediate early response to BMP4 in Xenopus embryos. The timing of expression and embryonic distribution of msx1 parallel those described for BMP4. Moreover, overexpression of msx1 in early Xenopus embryos leads to their ventralization as described for BMP4. Consistent with mediating a BMP type of signaling, overexpression of msx1 is sufficient to induce epidermis in dissociated ectoderm cells, which would otherwise form neural tissue. Finally, msx1 can also rescue neuralization imposed by a dominant negative BMP receptor (tBR) in ectodermal explants. We propose that Xenopus msx1 acts as a mediator of BMP signaling in epidermal induction and inhibition of neural differentiation.
This article has been cited by other articles:
|
|
 |
|
  A.-S. Tseng and M. Levin Tail Regeneration in Xenopus laevis as a Model for Understanding Tissue Repair J. Dent. Res., September 1, 2008; 87(9): 806 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. McCabe and M. Bronner-Fraser Essential role for PDGF signaling in ophthalmic trigeminal placode induction Development, May 15, 2008; 135(10): 1863 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Merrill, B. F. Eames, S. J. Weston, T. Heath, and R. A. Schneider Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis Development, April 1, 2008; 135(7): 1223 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Hu, L. T. Doan, D. S. Currle, M. Paff, J. Y. Rheem, R. Schreyer, B. Robert, and E. S. Monuki Border formation in a Bmp gradient reduced to single dissociated cells PNAS, March 4, 2008; 105(9): 3398 - 3403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Takahashi, A. Kamiya, A. Ishiguro, A. C. Suzuki, N. Saitou, A. Toyoda, and J. Aruga Conservation and Diversification of Msx Protein in Metazoan Evolution Mol. Biol. Evol., January 1, 2008; 25(1): 69 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chang and R. M. Harland Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation Development, November 1, 2007; 134(21): 3861 - 3872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Stoick-Cooper, R. T. Moon, and G. Weidinger Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine Genes & Dev., June 1, 2007; 21(11): 1292 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-S. Hong and J.-P. Saint-Jeannet The Activity of Pax3 and Zic1 Regulates Three Distinct Cell Fates at the Neural Plate Border Mol. Biol. Cell, June 1, 2007; 18(6): 2192 - 2202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Knockaert, G. Sapkota, C. Alarcon, J. Massague, and A. H. Brivanlou Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling PNAS, August 8, 2006; 103(32): 11940 - 11945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heasman Patterning the early Xenopus embryo. Development, April 1, 2006; 133(7): 1205 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Olguin, P. Oteiza, E. Gamboa, J. L. Gomez-Skarmeta, and M. Kukuljan RE-1 silencer of transcription/neural restrictive silencer factor modulates ectodermal patterning during Xenopus development. J. Neurosci., March 8, 2006; 26(10): 2820 - 2829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsuo-Takasaki, M. Matsumura, and Y. Sasai An essential role of Xenopus Foxi1a for ventral specification of the cephalic ectoderm during gastrulation Development, September 1, 2005; 132(17): 3885 - 3894. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Davis-Silberman, T. Kalich, V. Oron-Karni, T. Marquardt, M. Kroeber, E. R. Tamm, and R. Ashery-Padan Genetic dissection of Pax6 dosage requirements in the developing mouse eye Hum. Mol. Genet., August 1, 2005; 14(15): 2265 - 2276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Alliston, T. C. Ko, Y. Cao, Y.-Y. Liang, X.-H. Feng, C. Chang, and R. Derynck Repression of Bone Morphogenetic Protein and Activin-inducible Transcription by Evi-1 J. Biol. Chem., June 24, 2005; 280(25): 24227 - 24237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sato, N. Sasai, and Y. Sasai Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm Development, May 15, 2005; 132(10): 2355 - 2363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Stern Neural induction: old problem, new findings, yet more questions Development, May 1, 2005; 132(9): 2007 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tao, E. Kuliyev, X. Wang, X. Li, T. Wilanowski, S. M. Jane, P. E. Mead, and J. M. Cunningham BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation Development, March 1, 2005; 132(5): 1021 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Brugmann, P. D. Pandur, K. L. Kenyon, F. Pignoni, and S. A. Moody Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor Development, December 1, 2004; 131(23): 5871 - 5881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Tseng, R. Shah, and M. Jamrich Function and regulation of FoxF1 during Xenopus gut development Development, August 1, 2004; 131(15): 3637 - 3647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kaartinen, M. Dudas, A. Nagy, S. Sridurongrit, M. M. Lu, and J. A. Epstein Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells Development, July 15, 2004; 131(14): 3481 - 3490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Peng, B.-H. Jiang, P.-H. Yang, Z. Cao, X. Shi, M. C. M. Lin, M.-L. He, and H.-f. Kung Phosphatidylinositol 3-Kinase Signaling Is Involved in Neurogenesis during Xenopus Embryonic Development J. Biol. Chem., July 2, 2004; 279(27): 28509 - 28514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, A. W. Helms, and J. E. Johnson Distinct activities of Msx1 and Msx3 in dorsal neural tube development Development, March 1, 2004; 131(5): 1017 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Glavic, F. Silva, M. J. Aybar, F. Bastidas, and R. Mayor Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos Development, January 15, 2004; 131(2): 347 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tribulo, M. J. Aybar, V. H. Nguyen, M. C. Mullins, and R. Mayor Regulation of Msx genes by a Bmp gradient is essential for neural crest specification Development, December 29, 2003; 130(26): 6441 - 6452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Hussein, E. K. Duff, and C. Sirard Smad4 and {beta}-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2 J. Biol. Chem., December 5, 2003; 278(49): 48805 - 48814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. Blitz, K. W. Y. Cho, and C. Chang Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis Development, October 15, 2003; 130(20): 4975 - 4988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takebayashi-Suzuki, J. Funami, D. Tokumori, A. Saito, T. Watabe, K. Miyazono, A. Kanda, and A. Suzuki Interplay between the tumor suppressor p53 and TGF{beta} signaling shapes embryonic body axes in Xenopus Development, September 1, 2003; 130(17): 3929 - 3939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-I. Yabe, K. Tanegashima, Y. Haramoto, S. Takahashi, T. Fujii, S. Kozuma, Y. Taketani, and M. Asashima FRL-1, a member of the EGF-CFC family, is essential for neural differentiation in Xenopus early development Development, May 15, 2003; 130(10): 2071 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-I. Osada, S.-y. Ohmori, and M. Taira XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos Development, May 1, 2003; 130(9): 1783 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yang, C. Tan, R. S. Darken, P. A. Wilson, and P. S. Klein {beta}-Catenin/Tcf-regulated transcription prior to the midblastula transition Development, March 14, 2003; 129(24): 5743 - 5752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Timmer, C. Wang, and L. Niswander BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors Development, March 7, 2003; 129(10): 2459 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Spokony, Y. Aoki, N. Saint-Germain, E. Magner-Fink, and J.-P. Saint-Jeannet The transcription factor Sox9 is required for cranial neural crest development in Xenopus Development, March 3, 2003; 129(2): 421 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Woda, J. Pastagia, M. Mercola, and K. B. Artinger Dlx proteins position the neural plate border and determine adjacent cell fates Development, March 2, 2003; 130(2): 331 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shim, N. Bae, and J.-K. Han Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ) Nucleic Acids Res., July 15, 2002; 30(14): 3107 - 3117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhao, Q. Chen, F.-C. Hung, and P. A. Overbeek BMP signaling is required for development of the ciliary body Development, January 10, 2002; 129(19): 4435 - 4442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pizette, C. Abate-Shen, and L. Niswander BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb Development, November 15, 2001; 128(22): 4463 - 4474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Yamamoto, C. Takagi, A. C. Hyodo, and N. Ueno Suppression of head formation by Xmsx-1 through the inhibition of intracellular nodal signaling Development, July 15, 2001; 128(14): 2769 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Gomez-Skarmeta, E de La Calle-Mustienes, and J Modolell The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4 Development, January 2, 2001; 128(4): 551 - 560. [Abstract] [PDF]
|
|
|
|
|
|
C. Sirard, S. Kim, C. Mirtsos, P. Tadich, P. A. Hoodless, A. Itie, R. Maxson, J. L. Wrana, and T. W. Mak Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor beta -related Signaling J. Biol. Chem., January 21, 2000; 275(3): 2063 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Brewster, J. Mullor, and A Ruiz i Altaba Gli2 functions in FGF signaling during antero-posterior patterning Development, January 10, 2000; 127(20): 4395 - 4405. [Abstract] [PDF]
|
|
|
|
|
|
M Kishi, K Mizuseki, N Sasai, H Yamazaki, K Shiota, S Nakanishi, and Y Sasai Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm Development, January 2, 2000; 127(4): 791 - 800. [Abstract] [PDF]
|
|
|
|
|
|
Y. Kato, Y. Shi, and X. He Neuralization of the Xenopus Embryo by Inhibition of p300/ CREB-Binding Protein Function J. Neurosci., November 1, 1999; 19(21): 9364 - 9373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hollnagel, V. Oehlmann, J. Heymer, U. Ruther, and A. Nordheim Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells J. Biol. Chem., July 9, 1999; 274(28): 19838 - 19845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Meech, P. Kallunki, G. M. Edelman, and F. S. Jones A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins PNAS, March 2, 1999; 96(5): 2420 - 2425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Watanabe and M Whitman FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo Development, January 12, 1999; 126(24): 5621 - 5634. [Abstract] [PDF]
|
|
|
|
|
|
B. Latinkic and J. Smith Goosecoid and mix.1 repress Brachyury expression and are required for head formation in Xenopus Development, January 4, 1999; 126(8): 1769 - 1779. [Abstract] [PDF]
|
|
|
|
|
|
M. Macias-Silva, P. A. Hoodless, S. J. Tang, M. Buchwald, and J. L. Wrana Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2 J. Biol. Chem., October 2, 1998; 273(40): 25628 - 25636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takeda, H. Ichijo, M. Fujii, Y. Mochida, M. Saitoh, H. Nishitoh, T. K. Sampath, and K. Miyazono Identification of a Novel Bone Morphogenetic Protein-responsive Gene That May Function as a Noncoding RNA J. Biol. Chem., July 3, 1998; 273(27): 17079 - 17085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Bei and R Maas FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development Development, January 11, 1998; 125(21): 4325 - 4333. [Abstract] [PDF]
|
|
|
|
|
|
K. Kroll, A. Salic, L. Evans, and M. Kirschner Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation Development, January 8, 1998; 125(16): 3247 - 3258. [Abstract] [PDF]
|
|
|
|
|
|
P Lemaire, S Darras, D Caillol, and L Kodjabachian A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone Development, January 7, 1998; 125(13): 2371 - 2380. [Abstract] [PDF]
|
|
|
|
|
|
A. Schuler-Metz, S. Knochel, E. Kaufmann, and W. Knochel The Homeodomain Transcription Factor Xvent-2 Mediates Autocatalytic Regulation of BMP-4 Expression in Xenopus Embryos J. Biol. Chem., October 27, 2000; 275(44): 34365 - 34374. [Abstract] [Full Text] [PDF]
|
|
