Development, Vol 124, Issue 17 3449-3460, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Sequential expression and role of Hu RNA-binding proteins during neurogenesis

Y Wakamatsu and JA Weston
Institute of Neuroscience, University of Oregon, Eugene 97403-1254, USA.

We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation.

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