|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 18 3493-3500, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
Y Herault, N Fraudeau, J Zakany and D Duboule
Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland.
Ulnaless (Ul), an X-ray-induced dominant mutation in mice, severely disrupts development of forearms and forelegs. The mutation maps on chromosome 2, tightly linked to the HoxD complex, a cluster of regulatory genes required for proper morphogenesis. In particular, 5'-located (posterior) Hoxd genes are involved in limb development and combined mutations within these genes result in severe alterations in appendicular skeleton. We have used several engineered alleles of the HoxD complex to genetically assess the potential linkage between these two loci. We present evidence indicating that Ulnaless is allelic to Hoxd genes. Important modifications in the expression patterns of the posterior Hoxd-12 and Hoxd-13 genes at the Ul locus suggest that Ul is a regulatory mutation that interferes with a control mechanism shared by multiple genes to coordinate Hoxd function during limb morphogenesis.
This article has been cited by other articles:
|
|
 |
|
  B Dlugaszewska, A Silahtaroglu, C Menzel, S Kubart, M Cohen, S Mundlos, Z Tumer, K Kjaer, U Friedrich, H-H Ropers, et al. Breakpoints around the HOXD cluster result in various limb malformations J. Med. Genet., February 1, 2006; 43(2): 111 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Remington, T. J. Vision, T. J. Guilfoyle, and J. W. Reed Contrasting Modes of Diversification in the Aux/IAA and ARF Gene Families Plant Physiology, July 1, 2004; 135(3): 1738 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wood, E. Vang, J. Manning, J. Walton, S. Troup, C. Kingsland, and I. D. Lewis-Jones The Ratio of Second to Fourth Digit Length in Azoospermic Males Undergoing Surgical Sperm Retrieval: Predictive Value for Sperm Retrieval and on Subsequent Fertilization and Pregnancy Rates in IVF/ICSI Cycles J Androl, November 1, 2003; 24(6): 871 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Caronia, F. R. Goodman, C. M. E. McKeown, P. J. Scambler, and V. Zappavigna An I47L substitution in the HOXD13 homeodomain causes a novel human limb malformation by producing a selective loss of function Development, April 15, 2003; 130(8): 1701 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Swamynathan and J. Piatigorsky Orientation-dependent Influence of an Intergenic Enhancer on the Promoter Activity of the Divergently Transcribed Mouse Shsp/alpha B-crystallin and Mkbp/HspB2 Genes J. Biol. Chem., December 13, 2002; 277(51): 49700 - 49706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Sugawara, M Egashira, N Harada, T C Jakobs, K Yoshiura, T Kishino, T Ohta, N Niikawa, and N Matsumoto Breakpoint analysis of a familial balanced translocation t(2;8)(q31;p21) associated with mesomelic dysplasia J. Med. Genet., July 1, 2002; 39(7): e34 - 34. [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao and S. S. Potter Functional specificity of the Hoxa13 homeobox Development, August 15, 2001; 128(16): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kmita, F. van der Hoeven, J. Zákány, R. Krumlauf, and D. Duboule Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex Genes & Dev., January 15, 2000; 14(2): 198 - 211. [Abstract] [Full Text]
|
|
|
|
|
|
A Zuniga and R Zeller Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity Development, January 1, 1999; 126(1): 13 - 21. [Abstract] [PDF]
|
|
|
|
|
|
S. Ohtsuki and M. Levine GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo Genes & Dev., November 1, 1998; 12(21): 3325 - 3330. [Abstract] [Full Text]
|
|
|
|
|
|
Y Herault, J Beckers, T Kondo, N Fraudeau, and D Duboule Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex Development, January 5, 1998; 125(9): 1669 - 1677. [Abstract] [PDF]
|
|
