spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hacker, U.
Right arrow Articles by Perrimon, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hacker, U.
Right arrow Articles by Perrimon, N.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 124, Issue 18 3565-3573, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis

U Hacker, X Lin and N Perrimon
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

We have identified and characterized a Drosophila gene, which we have named sugarless, that encodes a homologue of vertebrate UDP-glucose dehydrogenase. This enzyme is essential for the biosynthesis of various proteoglycans, and we find that in the absence of both maternal and zygotic activities of this gene, mutant embryos develop with segment polarity phenotypes reminiscent to loss of either Wingless or Hedgehog signaling. To analyze the function of Sugarless in cell-cell interaction processes, we have focused our analysis on its requirement for Wingless signaling in different tissues. We report that sugarless mutations impair signaling by Wingless, suggesting that proteoglycans contribute to the reception of Wingless. We demonstrate that overexpression of Wingless can bypass the requirement for sugarless, suggesting that proteoglycans modulate signaling by Wingless, possibly by limiting its diffusion and thereby facilitating the binding of Wingless to its receptor. We discuss the possibility that tissue-specific regulation of proteoglycans may be involved in regulating both Wingless short- or long-range effects.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cold Spring Harb. Perspect. Biol.Home page
D. Yan and X. Lin
Shaping Morphogen Gradients by Proteoglycans
Cold Spring Harb Perspect Biol, September 1, 2009; 1(3): a002493 - a002493.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Cortes, A. T. Baria, and N. B. Schwartz
Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate
Development, May 15, 2009; 136(10): 1697 - 1706.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Wei, R. Galbenus, A. Raza, R. L. Cerny, and M. A. Simpson
Androgen-Stimulated UDP-Glucose Dehydrogenase Expression Limits Prostate Androgen Availability without Impacting Hyaluronan Levels
Cancer Res., March 15, 2009; 69(6): 2332 - 2339.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. J. Bornemann, S. Park, S. Phin, and R. Warrior
A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo
Development, March 15, 2008; 135(6): 1039 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhong, T. Desilva, L. Lin, P. Bodine, R. A. Bhat, E. Presman, J. Pocas, M. Stahl, and R. Kriz
Regulation of Secreted Frizzled-related Protein-1 by Heparin
J. Biol. Chem., July 13, 2007; 282(28): 20523 - 20533.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R.-J. Hung, H.-S. Chien, R.-Z. Lin, C.-T. Lin, J. Vatsyayan, H.-L. Peng, and H.-Y. Chang
Comparative Analysis of Two UDP-glucose Dehydrogenases in Pseudomonas aeruginosa PAO1
J. Biol. Chem., June 15, 2007; 282(24): 17738 - 17748.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Zhu, L. M. Stevens, and D. Stein
Synthesis of the sulfate donor PAPS in either the Drosophila germline or somatic follicle cells can support embryonic dorsal-ventral axis formation
Development, April 15, 2007; 134(8): 1465 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Vigetti, M. Ori, M. Viola, A. Genasetti, E. Karousou, M. Rizzi, F. Pallotti, I. Nardi, V. C. Hascall, G. De Luca, et al.
Molecular Cloning and Characterization of UDP-glucose Dehydrogenase from the Amphibian Xenopus laevis and Its Involvement in Hyaluronan Synthesis
J. Biol. Chem., March 24, 2006; 281(12): 8254 - 8263.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Beis, T. Bartman, S.-W. Jin, I. C. Scott, L. A. D'Amico, E. A. Ober, H. Verkade, J. Frantsve, H. A. Field, A. Wehman, et al.
Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development
Development, September 15, 2005; 132(18): 4193 - 4204.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Zhu, J. Sen, L. Stevens, J. S. Goltz, and D. Stein
Drosophila Pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans
Development, September 1, 2005; 132(17): 3813 - 3822.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
J. Vatsyayan, H.-L. Peng, and H.-Y. Chang
Analysis of Human UDP-Glucose Dehydrogenase Gene Promoter: Identification of an Sp1 Binding Site Crucial for the Expression of the Large Transcript
J. Biochem., June 1, 2005; 137(6): 703 - 709.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. R. Bastow, K. J. Lamb, J. C. Lewthwaite, A. C. Osborne, E. Kavanagh, C. P. D. Wheeler-Jones, and A. A. Pitsillides
Selective Activation of the MEK-ERK Pathway Is Regulated by Mechanical Stimuli in Forming Joints and Promotes Pericellular Matrix Formation
J. Biol. Chem., March 25, 2005; 280(12): 11749 - 11758.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
N. Kotani, S. Kitazume, K. Kamimura, S. Takeo, T. Aigaki, H. Nakato, and Y. Hashimoto
Characterization of Drosophila Aspartic Proteases That Induce the Secretion of a Golgi-Resident Transferase, Heparan Sulfate 6-O-Sulfotransferase
J. Biochem., March 1, 2005; 137(3): 315 - 322.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. Weber, N. Johnson, D. Champlin, and A. Patty
Many P-Element Insertions Affect Wing Shape in Drosophila melanogaster
Genetics, March 1, 2005; 169(3): 1461 - 1475.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Franch-Marro, O. Marchand, E. Piddini, S. Ricardo, C. Alexandre, and J.-P. Vincent
Glypicans shunt the Wingless signal between local signalling and further transport
Development, February 15, 2005; 132(4): 659 - 666.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Lin
Functions of heparan sulfate proteoglycans in cell signaling during development
Development, December 15, 2004; 131(24): 6009 - 6021.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. J. Zhu and M. P. Scott
Incredible journey: how do developmental signals travel through tissue?
Genes & Dev., December 15, 2004; 18(24): 2985 - 2997.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Perrimon, U. Hacker, B. Sanson, and T. Tabata
Wingless, Hedgehog and Heparan Sulfate Proteoglycans
Development, June 1, 2004; 131(11): 2509 - 2513.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. J. Sommer, J. J. Barycki, and M. A. Simpson
Characterization of Human UDP-glucose Dehydrogenase: CYS-276 IS REQUIRED FOR THE SECOND OF TWO SUCCESSIVE OXIDATIONS
J. Biol. Chem., May 28, 2004; 279(22): 23590 - 23596.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. J. Bornemann, J. E. Duncan, W. Staatz, S. Selleck, and R. Warrior
Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways
Development, May 1, 2004; 131(9): 1927 - 1938.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Takeo, M. Fujise, T. Akiyama, H. Habuchi, N. Itano, T. Matsuo, T. Aigaki, K. Kimata, and H. Nakato
In Vivo Hyaluronan Synthesis upon Expression of the Mammalian Hyaluronan Synthase Gene in Drosophila
J. Biol. Chem., April 30, 2004; 279(18): 18920 - 18925.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Han, T. Y. Belenkaya, M. Khodoun, M. Tauchi, X. Lin, and X. Lin
Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation
Development, April 1, 2004; 131(7): 1563 - 1575.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Tabata and Y. Takei
Morphogens, their identification and regulation
Development, February 15, 2004; 131(4): 703 - 712.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Takei, Y. Ozawa, M. Sato, A. Watanabe, and T. Tabata
Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
Development, January 1, 2004; 131(1): 73 - 82.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. S. Hickery, M. T. Bayliss, J. Dudhia, J. C. Lewthwaite, J. C. W. Edwards, and A. A. Pitsillides
Age-related Changes in the Response of Human Articular Cartilage to IL-1{alpha} and Transforming Growth Factor-{beta} (TGF-{beta}): CHONDROCYTES EXHIBIT A DIMINISHED SENSITIVITY TO TGF-{beta}
J. Biol. Chem., December 26, 2003; 278(52): 53063 - 53071.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. C. Desbordes and B. Sanson
The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila
Development, December 22, 2003; 130(25): 6245 - 6255.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Bink, H. Habuchi, Z. Lele, E. Dolk, J. Joore, G.-J. Rauch, R. Geisler, S. W. Wilson, J. den Hertog, K. Kimata, et al.
Heparan Sulfate 6-O-Sulfotransferase Is Essential for Muscle Development in Zebrafish
J. Biol. Chem., August 15, 2003; 278(33): 31118 - 31127.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
Q. Ch'ng, L. Williams, Y. S. Lie, M. Sym, J. Whangbo, and C. Kenyon
Identification of Genes That Regulate a Left-Right Asymmetric Neuronal Migration in Caenorhabditis elegans
Genetics, August 1, 2003; 164(4): 1355 - 1367.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kamiyama, T. Suda, R. Ueda, M. Suzuki, R. Okubo, N. Kikuchi, Y. Chiba, S. Goto, H. Toyoda, K. Saigo, et al.
Molecular Cloning and Identification of 3'-Phosphoadenosine 5'-Phosphosulfate Transporter
J. Biol. Chem., July 3, 2003; 278(28): 25958 - 25963.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B.-T. Kim, K. Tsuchida, J. Lincecum, H. Kitagawa, M. Bernfield, and K. Sugahara
Identification and Characterization of Three Drosophila melanogaster Glucuronyltransferases Responsible for the Synthesis of the Conserved Glycosaminoglycan-Protein Linkage Region of Proteoglycans. TWO NOVEL HOMOLOGS EXHIBIT BROAD SPECIFICITY TOWARD OLIGOSACCHARIDES FROM PROTEOGLYCANS, GLYCOPROTEINS, AND GLYCOSPHINGOLIPIDS
J. Biol. Chem., March 7, 2003; 278(11): 9116 - 9124.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. A. Micchelli, I. The, E. Selva, V. Mogila, and N. Perrimon
rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
Development, March 4, 2003; 129(4): 843 - 851.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-Y. Hwang and H. R. Horvitz
The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development
PNAS, October 29, 2002; 99(22): 14218 - 14223.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Y. Belenkaya, C. Han, H. J. Standley, X. Lin, D. W. Houston, J. Heasman, and X. Lin
pygopus encodes a nuclear protein essential for Wingless/Wnt signaling
Development, September 1, 2002; 129(17): 4089 - 4101.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Muller, F. Altmann, D. Zhou, and T. Hennet
The Drosophila melanogaster brainiac Protein Is a Glycolipid-specific beta 1,3N-Acetylglucosaminyltransferase
J. Biol. Chem., August 30, 2002; 277(36): 32417 - 32420.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Yamada, Y. Okada, M. Ueno, S. Iwata, S. S. Deepa, S. Nishimura, M. Fujita, I. Van Die, Y. Hirabayashi, and K. Sugahara
Determination of the Glycosaminoglycan-Protein Linkage Region Oligosaccharide Structures of Proteoglycans from Drosophila melanogaster and Caenorhabditis elegans
J. Biol. Chem., August 23, 2002; 277(35): 31877 - 31886.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. B. H. Wilson
Functional Characterization of Drosophila melanogaster Peptide O-Xylosyltransferase, the Key Enzyme for Proteoglycan Chain Initiation and Member of the Core 2/I N-Acetylglucosaminyltransferase Family
J. Biol. Chem., June 7, 2002; 277(24): 21207 - 21212.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. L. Moriarity, K. J. Hurt, A. C. Resnick, P. B. Storm, W. Laroy, R. L. Schnaar, and S. H. Snyder
UDP-glucuronate Decarboxylase, a Key Enzyme in Proteoglycan Synthesis. CLONING, CHARACTERIZATION, AND LOCALIZATION
J. Biol. Chem., May 3, 2002; 277(19): 16968 - 16975.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. E. Pace, T. Lebestky, T. Hummel, P. Arnoux, K. Kwan, and L. G. Baum
Characterization of a Novel Drosophila melanogaster Galectin. EXPRESSION IN DEVELOPING IMMUNE, NEURAL, AND MUSCLE TISSUES
J. Biol. Chem., April 5, 2002; 277(15): 13091 - 13098.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
N. B. Schwartz and M. Domowicz
Chondrodysplasias due to proteoglycan defects
Glycobiology, April 1, 2002; 12(4): 57R - 68R.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. W. Yip, P. Ferretti, and A. J. Copp
Heparan sulphate proteoglycans and spinal neurulation in the mouse embryo
Development, January 5, 2002; 129(9): 2109 - 2119.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
D.Y.R. STAINIER, D. BEIS, B. JUNGBLUT, and T. BARTMAN
Endocardial Cushion Formation in Zebrafish
Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 49 - 56.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Llimargas and P. A. Lawrence
Seven Wnt homologues in Drosophila: A case study of the developing tracheae
PNAS, November 15, 2001; (2001) 251304398.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
S. S. Blair
Wnts, Signaling and Sulfates
Sci. Signal., September 25, 2001; 2001(101): pe32 - pe32.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
E. C. Walsh and D. Y. R. Stainier
UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish
Science, August 31, 2001; 293(5535): 1670 - 1673.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y Lin, S Zhang, M Rehn, P Itaranta, J Tuukkanen, R Heljasvaara, H Peltoketo, T Pihlajaniemi, and S Vainio
Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C
Development, January 5, 2001; 128(9): 1573 - 1585.
[Abstract] [PDF]

Home page
 DevelopmentHome page
G. Baeg, X Lin, N Khare, S Baumgartner, and N Perrimon
Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless
Development, January 1, 2001; 128(1): 87 - 94.
[Abstract] [PDF]

Home page
 GeneticsHome page
D. M. Eisenmann and S. K. Kim
Protruding Vulva Mutants Identify Novel Loci and Wnt Signaling Factors That Function During Caenorhabditis elegans Vulva Development
Genetics, November 1, 2000; 156(3): 1097 - 1116.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
C. E. Bandtlow and D. R. Zimmermann
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Physiol Rev, October 1, 2000; 80(4): 1267 - 1290.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Bulik, G. Wei, H. Toyoda, A. Kinoshita-Toyoda, W. R. Waldrip, J. D. Esko, P. W. Robbins, and S. B. Selleck
sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis
PNAS, September 26, 2000; 97(20): 10838 - 10843.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
A. Seppo and M. Tiemeyer
Function and structure of Drosophila glycans
Glycobiology, April 1, 2000; 10(8): 751 - 760.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Uren, F. Reichsman, V. Anest, W. G. Taylor, K. Muraiso, D. P. Bottaro, S. Cumberledge, and J. S. Rubin
Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling
J. Biol. Chem., February 11, 2000; 275(6): 4374 - 4382.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Toyoda, A. Kinoshita-Toyoda, and S. B. Selleck
Structural Analysis of Glycosaminoglycans in Drosophila and Caenorhabditis elegans and Demonstration That tout-velu, a Drosophila Gene Related to EXT Tumor Suppressors, Affects Heparan Sulfate in Vivo
J. Biol. Chem., January 28, 2000; 275(4): 2269 - 2275.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Habuchi, M. Tanaka, O. Habuchi, K. Yoshida, H. Suzuki, K. Ban, and K. Kimata
The Occurrence of Three Isoforms of Heparan Sulfate 6-O-Sulfotransferase Having Different Specificities for Hexuronic Acid Adjacent to the Targeted N-Sulfoglucosamine
J. Biol. Chem., January 28, 2000; 275(4): 2859 - 2868.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
A. D. Lander and S. B. Selleck
The Elusive Functions of Proteoglycans: In Vivo Veritas
J. Cell Biol., January 24, 2000; 148(2): 227 - 232.
[Full Text] [PDF]

Home page
 DevelopmentHome page
C Goutte, W Hepler, K. Mickey, and J. Priess
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
Development, January 6, 2000; 127(11): 2481 - 2492.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M. Myat and D. Andrew
Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia
Development, January 2, 2000; 127(4): 679 - 691.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
J. Lapointe and C. Labrie
Identification and Cloning of a Novel Androgen-Responsive Gene, Uridine Diphosphoglucose Dehydrogenase, in Human Breast Cancer Cells
Endocrinology, October 1, 1999; 140(10): 4486 - 4493.
[Abstract] [Full Text]

Home page
 GeneticsHome page
A. C. Spradling, D. Stern, A. Beaton, E. J. Rhem, T. Laverty, N. Mozden, S. Misra, and G. M. Rubin
The Berkeley Drosophila Genome Project Gene Disruption Project: Single P-Element Insertions Mutating 25% of Vital Drosophila Genes
Genetics, September 1, 1999; 153(1): 135 - 177.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. L. R. Merry, M. Lyon, J. A. Deakin, J. J. Hopwood, and J. T. Gallagher
Highly Sensitive Sequencing of the Sulfated Domains of Heparan Sulfate
J. Biol. Chem., June 25, 1999; 274(26): 18455 - 18462.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Kakuta, T. Sueyoshi, M. Negishi, and L. C. Pedersen
Crystal Structure of the Sulfotransferase Domain of Human Heparan Sulfate N-Deacetylase/ N-Sulfotransferase 1
J. Biol. Chem., April 16, 1999; 274(16): 10673 - 10676.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Chen and G Struhl
Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
Development, January 12, 1999; 126(23): 5441 - 5452.
[Abstract] [PDF]

Home page
 DevelopmentHome page
X Lin, E. Buff, N Perrimon, and A. Michelson
Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
Development, January 9, 1999; 126(17): 3715 - 3723.
[Abstract] [PDF]

Home page
 DevelopmentHome page
P Bhanot, M Fish, J. Jemison, R Nusse, J Nathans, and K. Cadigan
Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development
Development, January 9, 1999; 126(18): 4175 - 4186.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H Muller, R Samanta, and E Wieschaus
Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes
Development, January 2, 1999; 126(3): 577 - 586.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
A. P. Spicer, L. A. Kaback, T. J. Smith, and M. F. Seldin
Molecular Cloning and Characterization of the Human and Mouse UDP-Glucose Dehydrogenase Genes
J. Biol. Chem., September 25, 1998; 273(39): 25117 - 25124.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. H. Taylor, A. Sinha, I. A. Khan, S. T. McDaniel, and J. D. Esko
Primers of Glycosaminoglycan Biosynthesis from Peruvian Rain Forest Plants
J. Biol. Chem., August 28, 1998; 273(35): 22260 - 22266.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. L. Bullock, J. M. Fletcher, R. S.P. Beddington, and V. A. Wilson
Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
Genes & Dev., June 15, 1998; 12(12): 1894 - 1906.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
H. Dierick and A Bejsovec
Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling
Development, January 12, 1998; 125(23): 4729 - 4738.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Kispert, S Vainio, and A. McMahon
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney
Development, January 11, 1998; 125(21): 4225 - 4234.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
K. M. Cadigan and R. Nusse
Wnt signaling: a common theme in animal development
Genes & Dev., December 15, 1997; 11(24): 3286 - 3305.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Ringvall, J. Ledin, K. Holmborn, T. van Kuppevelt, F. Ellin, I. Eriksson, A.-M. Olofsson, L. Kjellen, and E. Forsberg
Defective Heparan Sulfate Biosynthesis and Neonatal Lethality in Mice Lacking N-Deacetylase/N-Sulfotransferase-1
J. Biol. Chem., August 18, 2000; 275(34): 25926 - 25930.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Toyoda, A. Kinoshita-Toyoda, B. Fox, and S. B. Selleck
Structural Analysis of Glycosaminoglycans in Animals Bearing Mutations in sugarless, sulfateless, and tout-velu. DROSOPHILA HOMOLOGUES OF VERTEBRATE GENES ENCODING GLYCOSAMINOGLYCAN BIOSYNTHETIC ENZYMES
J. Biol. Chem., July 14, 2000; 275(29): 21856 - 21861.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. C. Pedersen, K. Tsuchida, H. Kitagawa, K. Sugahara, T. A. Darden, and M. Negishi
Heparan/Chondroitin Sulfate Biosynthesis. STRUCTURE AND MECHANISM OF HUMAN GLUCURONYLTRANSFERASE I
J. Biol. Chem., October 27, 2000; 275(44): 34580 - 34585.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. L. R. Merry, S. L. Bullock, D. C. Swan, A. C. Backen, M. Lyon, R. S. P. Beddington, V. A. Wilson, and J. T. Gallagher
The Molecular Phenotype of Heparan Sulfate in the Hs2st-/- Mutant Mouse
J. Biol. Chem., September 14, 2001; 276(38): 35429 - 35434.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Berninsone, H.-Y. Hwang, I. Zemtseva, H. R. Horvitz, and C. B. Hirschberg
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose
PNAS, March 27, 2001; 98(7): 3738 - 3743.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Llimargas and P. A. Lawrence
Seven Wnt homologues in Drosophila: A case study of the developing tracheae
PNAS, December 4, 2001; 98(25): 14487 - 14492.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1997