|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 18 3575-3586, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
D Meyer, T Yamaai, A Garratt, E Riethmacher-Sonnenberg, D Kane, LE Theill and C Birchmeier
Max-Delbruck-Center for Molecular Medicine, Department of Medical Genetics, Berlin, Germany.
Neuregulin (also known as NDF, heregulin, ARIA, GGF or SMDF), induces cell growth and differentiation. Biological effects of neuregulin are mediated by members of the erbB family of tyrosine kinase receptors. Three major neuregulin isoforms are produced from the gene, which differ substantially in sequence and in overall structure. Here we use in situ hybridization with isoform-specific probes to illustrate the spatially distinct patterns of expression of the isoforms during mouse development. Ablation of the neuregulin gene in the mouse has demonstrated multiple and independent functions of this factor in development of both the nervous system and the heart. We show here that targeted mutations that affect different isoforms result in distinct phenotypes, demonstrating that isoforms can take over specific functions in vivo. Type I neuregulin is required for generation of neural crest-derived neurons in cranial ganglia and for trabeculation of the heart ventricle, whereas type III neuregulin plays an important role in the early development of Schwann cells. The complexity of neuregulin functions in development is therefore due to independent roles played by distinct isoforms.
This article has been cited by other articles:
|
|
 |
|
  Y.-J. J. Chen, M. A. Johnson, M. D. Lieberman, R. E. Goodchild, S. Schobel, N. Lewandowski, G. Rosoklija, R.-C. Liu, J. A. Gingrich, S. Small, et al. Type III Neuregulin-1 Is Required for Normal Sensorimotor Gating, Memory-Related Behaviors, and Corticostriatal Circuit Components J. Neurosci., July 2, 2008; 28(27): 6872 - 6883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Holtzman, J. J. Schoenebeck, H.-J. Tsai, and D. Yelon Endocardium is necessary for cardiomyocyte movement during heart tube assembly Development, June 15, 2007; 134(12): 2379 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yokozeki, S. Wakatsuki, K. Hatsuzawa, R. A. Black, I. Wada, and A. Sehara-Fujisawa Meltrin {beta} (ADAM19) mediates ectodomain shedding of Neuregulin {beta}1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells Genes Cells, March 1, 2007; 12(3): 329 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Montero, R. Rodriguez-Barrueco, L. Yuste, P. P. Juanes, J. Borges, A. Esparis-Ogando, and A. Pandiella The Extracellular Linker of pro-Neuregulin-{alpha}2c Is Required for Efficient Sorting and Juxtacrine Function Mol. Biol. Cell, February 1, 2007; 18(2): 380 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Mann, S. Das, J. Zhang, M. Wagner, and G. D. Fischbach Neuregulin Effect on Quantal Content Dissociated From Effect on Miniature Endplate Potential Amplitude J Neurophysiol, August 1, 2006; 96(2): 671 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Hayworth, S. E. Moody, L. A. Chodosh, P. Krieg, M. Rimer, and W. J. Thompson Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervation. J. Neurosci., June 21, 2006; 26(25): 6873 - 6884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-H. Tsai, W. B. Macklin, and R. H. Miller Netrin-1 Is Required for the Normal Development of Spinal Cord Oligodendrocytes J. Neurosci., February 15, 2006; 26(7): 1913 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yuste, A. Esparis-Ogando, E. Santos, and A. Pandiella Overexpression of RasN17 Fails to Neutralize Endogenous Ras in MCF7 Breast Cancer Cells J. Biochem., June 1, 2005; 137(6): 731 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Guertin, D. P. Zhang, K. S. Mak, J. A. Alberta, and H. A. Kim Microanatomy of Axon/Glial Signaling during Wallerian Degeneration J. Neurosci., March 30, 2005; 25(13): 3478 - 3487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Brown, K. Deb, B. C. Paria, S. K. Das, and J. Reese Embryo-Uterine Interactions via the Neuregulin Family of Growth Factors During Implantation in the Mouse Biol Reprod, December 1, 2004; 71(6): 2003 - 2011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gambarotta, D. Garzotto, E. Destro, B. Mautino, C. Giampietro, S. Cutrupi, C. Dati, E. Cattaneo, A. Fasolo, and I. Perroteau ErbB4 Expression in Neural Progenitor Cells (ST14A) Is Necessary to Mediate Neuregulin-1{beta}1-induced Migration J. Biol. Chem., November 19, 2004; 279(47): 48808 - 48816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Corfas, M. O. Velardez, C.-P. Ko, N. Ratner, and E. Peles Mechanisms and Roles of Axon-Schwann Cell Interactions J. Neurosci., October 20, 2004; 24(42): 9250 - 9260. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Jacobson, D. Duggan, and G. Fischbach Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle PNAS, August 17, 2004; 101(33): 12218 - 12223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Trinidad and J. B. Cohen Neuregulin Inhibits Acetylcholine Receptor Aggregation in Myotubes J. Biol. Chem., July 23, 2004; 279(30): 31622 - 31628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. V. Michailov, M. W. Sereda, B. G. Brinkmann, T. M. Fischer, B. Haug, C. Birchmeier, L. Role, C. Lai, M. H. Schwab, and K.-A. Nave Axonal Neuregulin-1 Regulates Myelin Sheath Thickness Science, April 30, 2004; 304(5671): 700 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. H. Huijbregts, K. A. Roth, R. E. Schmidt, and S. L. Carroll Hypertrophic Neuropathies and Malignant Peripheral Nerve Sheath Tumors in Transgenic Mice Overexpressing Glial Growth Factor {beta}3 in Myelinating Schwann Cells J. Neurosci., August 13, 2003; 23(19): 7269 - 7280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Kim, Q. Sun, M. Oglesbee, and S. O. Yoon The Role of ErbB2 Signaling in the Onset of Terminal Differentiation of Oligodendrocytes In Vivo J. Neurosci., July 2, 2003; 23(13): 5561 - 5571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bao, D. Wolpowitz, L. W. Role, and D. A. Talmage Back signaling by the Nrg-1 intracellular domain J. Cell Biol., June 23, 2003; 161(6): 1133 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Schmid, B. McGrath, B. E. Berechid, B. Boyles, M. Marchionni, N. Sestan, and E. S. Anton Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex PNAS, April 1, 2003; 100(7): 4251 - 4256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Yau, H.-F. Wang, C. Lai, and F.-C. Liu Neural Development of the Neuregulin Receptor ErbB4 in the Cerebral Cortex and the Hippocampus: Preferential Expression by Interneurons Tangentially Migrating from the Ganglionic Eminences Cereb Cortex, March 1, 2003; 13(3): 252 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. CRONE and K.-F. LEE Gene Targeting Reveals Multiple Essential Functions of the Neuregulin Signaling System during Development of the Neuroendocrine and Nervous Systems Ann. N.Y. Acad. Sci., October 1, 2002; 971(1): 547 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rentschler, J. Zander, K. Meyers, D. France, R. Levine, G. Porter, S. A. Rivkees, G. E. Morley, and G. I. Fishman Neuregulin-1 promotes formation of the murine cardiac conduction system PNAS, August 6, 2002; 99(16): 10464 - 10469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Wanner and P. M. Wood N-Cadherin Mediates Axon-Aligned Process Growth and Cell-Cell Interaction in Rat Schwann Cells J. Neurosci., May 15, 2002; 22(10): 4066 - 4079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Oka, T. Yoshino, K. Hayashi, N. Ohara, T. Nakanishi, Y. Yamaai, A. Hiraki, C. A. Sogawa, E. Kondo, N. Teramoto, et al. Reduction of Hematopoietic Cell-Specific Tyrosine Phosphatase SHP-1 Gene Expression in Natural Killer Cell Lymphoma and Various Types of Lymphomas/Leukemias : Combination Analysis with cDNA Expression Array and Tissue Microarray Am. J. Pathol., October 1, 2001; 159(4): 1495 - 1505. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Liu, B. Ford, M. A. Mann, and G. D. Fischbach Neuregulins Increase {alpha}7 Nicotinic Acetylcholine Receptors and Enhance Excitatory Synaptic Transmission in GABAergic Interneurons of the Hippocampus J. Neurosci., August 1, 2001; 21(15): 5660 - 5669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Calaora, B. Rogister, K. Bismuth, K. Murray, H. Brandt, P. Leprince, M. Marchionni, and M. Dubois-Dalcq Neuregulin Signaling Regulates Neural Precursor Growth and the Generation of Oligodendrocytes In Vitro J. Neurosci., July 1, 2001; 21(13): 4740 - 4751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Britsch, D. E. Goerich, D. Riethmacher, R. I. Peirano, M. Rossner, K.-A. Nave, C. Birchmeier, and M. Wegner The transcription factor Sox10 is a key regulator of peripheral glial development Genes & Dev., January 1, 2001; 15(1): 66 - 78. [Abstract] [Full Text]
|
|
|
|
|
|
A. I. Flores, B. S. Mallon, T. Matsui, W. Ogawa, A. Rosenzweig, T. Okamoto, and W. B. Macklin Akt-Mediated Survival of Oligodendrocytes Induced by Neuregulins J. Neurosci., October 15, 2000; 20(20): 7622 - 7630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Garratt, O. Voiculescu, P. Topilko, P. Charnay, and C. Birchmeier A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool J. Cell Biol., March 6, 2000; 148(5): 1035 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Wakamatsu, T. Maynard, and J. Weston Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis Development, January 7, 2000; 127(13): 2811 - 2821. [Abstract] [PDF]
|
|
|
|
|
|
J. Barrow, H. Stadler, and M. Capecchi Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse Development, January 3, 2000; 127(5): 933 - 944. [Abstract] [PDF]
|
|
|
|
|
|
K. R. JESSEN and R. MIRSKY Why Do Schwann Cells Survive in the Absence of Axons? Ann. N.Y. Acad. Sci., September 14, 1999; 883(1): 109 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Eagleson and P. Levitt Complex Signaling Responsible for Molecular Regionalization of the Cerebral Cortex Cereb Cortex, September 1, 1999; 9(6): 562 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rohrbach, X. Yan, E. O. Weinberg, F. Hasan, J. Bartunek, M. A. Marchionni, and B. H. Lorell Neuregulin in Cardiac Hypertrophy in Rats With Aortic Stenosis : Differential Expression of erbB2 and erbB4 Receptors Circulation, July 27, 1999; 100(4): 407 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Loeb, T. Khurana, J. Robbins, A. Yee, and G. Fischbach Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development Development, January 2, 1999; 126(4): 781 - 791. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Sundaresan, P. E. Roberts, K. L. King, M. X. Sliwkowski, and J. P. Mather Biological Response to ErbB Ligands in Nontransformed Cell Lines Correlates with a Specific Pattern of Receptor Expression Endocrinology, December 1, 1998; 139(12): 4756 - 4764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.S. Baldwin and M. Artman Recent advances in cardiovascular development: promise for the future Cardiovasc Res, December 1, 1998; 40(3): 456 - 468. [Full Text] [PDF]
|
|
|
|
|
|
A. Schroering and D. J. Carey Sensory and Motor Neuron-derived Factor Is a Transmembrane Heregulin That Is Expressed on the Plasma Membrane with the Active Domain Exposed to the Extracellular Environment J. Biol. Chem., November 13, 1998; 273(46): 30643 - 30650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rahmatullah, A. Schroering, K. Rothblum, R. C. Stahl, B. Urban, and D. J. Carey Synergistic Regulation of Schwann Cell Proliferation by Heregulin and Forskolin Mol. Cell. Biol., November 1, 1998; 18(11): 6245 - 6252. [Abstract] [Full Text]
|
|
|
|
|
|
C. Niemann, V. Brinkmann, E. Spitzer, G. Hartmann, M. Sachs, H. Naundorf, and W. Birchmeier Reconstitution of Mammary Gland Development In Vitro: Requirement of c-met and c-erbB2 Signaling for Branching and Alveolar Morphogenesis J. Cell Biol., October 19, 1998; 143(2): 533 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Crovello, C. Lai, L. C. Cantley, and K. L. Carraway III Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2 J. Biol. Chem., October 9, 1998; 273(41): 26954 - 26961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Britsch, L. Li, S. Kirchhoff, F. Theuring, V. Brinkmann, C. Birchmeier, and D. Riethmacher The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system Genes & Dev., June 15, 1998; 12(12): 1825 - 1836. [Abstract] [Full Text]
|
|
|
|
|
|
Y Wakamatsu, M Mochii, K. Vogel, and J. Weston Avian neural crest-derived neurogenic precursors undergo apoptosis on the lateral migration pathway Development, January 11, 1998; 125(21): 4205 - 4213. [Abstract] [PDF]
|
|
|
|
|
|
J. Y. Wang, S. J. Miller, and D. L. Falls The N-terminal Region of Neuregulin Isoforms Determines the Accumulation of Cell Surface and Released Neuregulin Ectodomain J. Biol. Chem., January 19, 2001; 276(4): 2841 - 2851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Suarez, D. Bach, J. Cadefau, M. Palacin, A. Zorzano, and A. Guma A Novel Role of Neuregulin in Skeletal Muscle. NEUREGULIN STIMULATES GLUCOSE UPTAKE, GLUCOSE TRANSPORTER TRANSLOCATION, AND TRANSPORTER EXPRESSION IN MUSCLE CELLS J. Biol. Chem., May 18, 2001; 276(21): 18257 - 18264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Cameron, L. Dryer, and S. E. Dryer beta -Neuregulin-1 is required for the in vivo development of functional Ca2+-activated K+ channels in parasympathetic neurons PNAS, February 27, 2001; 98(5): 2832 - 2836. [Abstract] [Full Text] [PDF]
|
|
