spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jensen, A. M.
Right arrow Articles by Wallace, V. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jensen, A. M.
Right arrow Articles by Wallace, V. A.

Development, Vol 124, Issue 2 363-371, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina

AM Jensen and VA Wallace
MRC Developmental Neurobiology Programme, University College London, UK.

We show that Sonic hedgehog and patched are expressed in adjacent domains in the developing mouse retina. Treatment of cultures of perinatal mouse retinal cells with the amino-terminal fragment of Sonic hedgehog protein results in an increase in the proportion of cells that incorporate bromodeoxuridine, in total cell numbers, and in rod photoreceptors, amacrine cells and Muller glial cells, suggesting that Sonic hedgehog promotes the proliferation of retinal precursor cells. These findings suggest that hedgehog and patched are part of a conserved signalling pathway in retinal development in mammals and insects.


This article has been cited by other articles:


Home page
 Genes Dev.Home page
M. Varjosalo and J. Taipale
Hedgehog: functions and mechanisms
Genes & Dev., September 15, 2008; 22(18): 2454 - 2472.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. Pan, M. Deng, X. Xie, and L. Gan
ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells
Development, June 1, 2008; 135(11): 1981 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. P. Fogarty, B. A. Emmenegger, L. L. Grasfeder, T. G. Oliver, and R. J. Wechsler-Reya
Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells
PNAS, February 20, 2007; 104(8): 2973 - 2978.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Liu, S. Thurig, O. Mohamed, D. Dufort, and V. A. Wallace
Mapping Canonical Wnt Signaling in the Developing and Adult Retina
Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 5088 - 5097.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Locker, M. Agathocleous, M. A. Amato, K. Parain, W. A. Harris, and M. Perron
Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors.
Genes & Dev., November 1, 2006; 20(21): 3036 - 3048.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Hashimoto, X.-M. Zhang, B. Y.-k. Chen, and X.-J. Yang
VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation
Development, June 1, 2006; 133(11): 2201 - 2210.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
E. Banin, A. Obolensky, M. Idelson, I. Hemo, E. Reinhardtz, E. Pikarsky, T. Ben-Hur, and B. Reubinoff
Retinal Incorporation and Differentiation of Neural Precursors Derived from Human Embryonic Stem Cells
Stem Cells, February 1, 2006; 24(2): 246 - 257.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Wang, G. D. Dakubo, S. Thurig, C. J. Mazerolle, and V. A. Wallace
Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina
Development, November 15, 2005; 132(22): 5103 - 5113.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. L. Close, B. Gumuscu, and T. A. Reh
Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF{beta} signaling
Development, July 1, 2005; 132(13): 3015 - 3026.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. D. Cote, Y. De Repentigny, S. G. Coupland, Y. Schwab, M. J. Roux, S. R. Levinson, and R. Kothary
Physiological Maturation of Photoreceptors Depends on the Voltage-Gated Sodium Channel NaV1.6 (Scn8a)
J. Neurosci., May 18, 2005; 25(20): 5046 - 5050.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. West, W. D. Richardson, and M. Fruttiger
Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes
Development, April 15, 2005; 132(8): 1855 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Ooto, T. Akagi, R. Kageyama, J. Akita, M. Mandai, Y. Honda, and M. Takahashi
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
PNAS, September 14, 2004; 101(37): 13654 - 13659.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Shkumatava, S. Fischer, F. Muller, U. Strahle, and C. J. Neumann
Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina
Development, August 15, 2004; 131(16): 3849 - 3858.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Kessaris, F. Jamen, L. L. Rubin, and W. D. Richardson
Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors
Development, March 15, 2004; 131(6): 1289 - 1298.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Moshiri and T. A. Reh
Persistent Progenitors at the Retinal Margin of ptc+/- Mice
J. Neurosci., January 7, 2004; 24(1): 229 - 237.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
K. Kasai, M. Takahashi, N. Osumi, S. Sinnarajah, T. Takeo, H. Ikeda, J. H. Kehrl, G. Itoh, and H. Arnheiter
The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling
Genes Cells, January 1, 2004; 9(1): 49 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
G. C.M. Black, C. J. Mazerolle, Y. Wang, K. D. Campsall, D. Petrin, B. C. Leonard, K. F. Damji, D. G. Evans, D. McLeod, and V. A. Wallace
Abnormalities of the vitreoretinal interface caused by dysregulated Hedgehog signaling during retinal development
Hum. Mol. Genet., December 15, 2003; 12(24): 3269 - 3276.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. D. Dakubo, Y. P. Wang, C. Mazerolle, K. Campsall, A. P. McMahon, and V. A. Wallace
Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development
Development, July 1, 2003; 130(13): 2967 - 2980.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Perron, S. Boy, M. A. Amato, A. Viczian, K. Koebernick, T. Pieler, and W. A. Harris
A novel function for Hedgehog signalling in retinal pigment epithelium differentiation
Development, April 15, 2003; 130(8): 1565 - 1577.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. A. Ros, R. D. Dahn, M. Fernandez-Teran, K. Rashka, N. C. Caruccio, S. M. Hasso, J. J. Bitgood, J. J. Lancman, and J. F. Fallon
The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb
Development, February 1, 2003; 130(3): 527 - 537.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. S. Green, J. L. Stubbs, and E. M. Levine
Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators
Development, February 1, 2003; 130(3): 539 - 552.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. M. Kenney, M. D. Cole, and D. H. Rowitch
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
Development, January 1, 2003; 130(1): 15 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Nicot, V. Lelievre, J. Tam, J. A. Waschek, and E. DiCicco-Bloom
Pituitary Adenylate Cyclase-Activating Polypeptide and Sonic Hedgehog Interact to Control Cerebellar Granule Precursor Cell Proliferation
J. Neurosci., November 1, 2002; 22(21): 9244 - 9254.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Zhang, Y. Song, X. Zhao, X. Zhang, C. Fermin, and Y. Chen
Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis
Development, September 1, 2002; 129(17): 4135 - 4146.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. J. Solecki, M. Gromeier, S. Mueller, G. Bernhardt, and E. Wimmer
Expression of the Human Poliovirus Receptor/CD155 Gene Is Activated by Sonic Hedgehog
J. Biol. Chem., July 5, 2002; 277(28): 25697 - 25702.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
F. Hsiung and K. Moses
Retinal development in Drosophila: specifying the first neuron
Hum. Mol. Genet., May 15, 2002; 11(10): 1207 - 1214.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Fruttiger
Development of the Mouse Retinal Vasculature: Angiogenesis Versus Vasculogenesis
Invest. Ophthalmol. Vis. Sci., February 1, 2002; 43(2): 522 - 527.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Rallu, R. Machold, N. Gaiano, J. G. Corbin, A. P. McMahon, and G. Fishell
Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling
Development, January 11, 2002; 129(21): 4963 - 4974.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
L.-A. D. Miller, S. E. Wert, and J. A. Whitsett
Immunolocalization of Sonic Hedgehog (Shh) in Developing Mouse Lung
J. Histochem. Cytochem., December 1, 2001; 49(12): 1593 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. ten Berge, A. Brouwer, J. Korving, M. J. Reijnen, E. J. van Raaij, F. Verbeek, W. Gaffield, and F. Meijlink
Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis
Development, August 1, 2001; 128(15): 2929 - 2938.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Zhang and X. Yang
Regulation of retinal ganglion cell production by Sonic hedgehog
Development, January 3, 2001; 128(6): 943 - 957.
[Abstract] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. M. Kenney and D. H. Rowitch
Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
Mol. Cell. Biol., December 1, 2000; 20(23): 9055 - 9067.
[Abstract] [Full Text]

Home page
 ScienceHome page
C. Neumann and Nuesslein-Volhard
Patterning of the Zebrafish Retina by a Wave of Sonic Hedgehog
Science, September 22, 2000; 289(5487): 2137 - 2139.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
M Hebrok, S. Kim, B St Jacques, A. McMahon, and D. Melton
Regulation of pancreas development by hedgehog signaling
Development, January 11, 2000; 127(22): 4905 - 4913.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
D. H. Rowitch, B. St.-Jacques, S. M. K. Lee, J. D. Flax, E. Y. Snyder, and A. P. McMahon
Sonic hedgehog Regulates Proliferation and Inhibits Differentiation of CNS Precursor Cells
J. Neurosci., October 15, 1999; 19(20): 8954 - 8965.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
B. St-Jacques, M. Hammerschmidt, and A. P. McMahon
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
Genes & Dev., August 15, 1999; 13(16): 2072 - 2086.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
K. McCabe, E. Gunther, and T. Reh
The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation
Development, January 12, 1999; 126(24): 5713 - 5724.
[Abstract] [PDF]

Home page
 DevelopmentHome page
L Milenkovic, L. Goodrich, K. Higgins, and M. Scott
Mouse patched1 controls body size determination and limb patterning
Development, January 10, 1999; 126(20): 4431 - 4440.
[Abstract] [PDF]

Home page
 DevelopmentHome page
V. Wallace and M. Raff
A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
Development, January 7, 1999; 126(13): 2901 - 2909.
[Abstract] [PDF]

Home page
 DevelopmentHome page
N Dahmane and A Ruiz-i-Altaba
Sonic hedgehog regulates the growth and patterning of the cerebellum
Development, January 6, 1999; 126(14): 3089 - 3100.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
A. J. Kalyani, D. Piper, T. Mujtaba, M. T. Lucero, and M. S. Rao
Spinal Cord Neuronal Precursors Generate Multiple Neuronal Phenotypes in Culture
J. Neurosci., October 1, 1998; 18(19): 7856 - 7868.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L Laforest, C. Brown, G Poleo, J Geraudie, M Tada, M Ekker, and M. Akimenko
Involvement of the sonic hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays
Development, January 11, 1998; 125(21): 4175 - 4184.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Duprez, C Fournier-Thibault, and N Le Douarin
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb
Development, January 2, 1998; 125(3): 495 - 505.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Borycki, L Mendham, and C. Emerson
Control of somite patterning by Sonic hedgehog and its downstream signal response genes
Development, January 2, 1998; 125(4): 777 - 790.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
E. M. Levine, H. Roelink, J. Turner, and T. A. Reh
Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro
J. Neurosci., August 15, 1997; 17(16): 6277 - 6288.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. Williams and C. Ordahl
Emergence of determined myotome precursor cells in the somite
Development, January 12, 1997; 124(24): 4983 - 4997.
[Abstract] [PDF]


© The Company of Biologists Ltd 1997