|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 2 381-389, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
W Liao, BW Bisgrove, H Sawyer, B Hug, B Bell, K Peters, DJ Grunwald and DY Stainier
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0554, USA.
The zebrafish cloche mutation affects both the endothelial and hematopoietic lineages at a very early stage (Stainier, D. Y. R., Weinstein, B. M., Detrich, H. W., Zon, L. I. and Fishman, M. C. (1995). Development 121, 3141-3150). The most striking vascular phenotype is the absence of endocardial cells from the heart. Microscopic examination of mutant embryos reveals the presence of endothelial-like cells in the lower trunk and tail regions while head vessels appear to be missing, indicating a molecular diversification of the endothelial lineage. Cell transplantation experiments show that cloche acts cell-autonomously within the endothelial lineage. To analyze further the role of cloche in regulating endothelial cell differentiation, we have examined the expression of flk-1 and tie, two receptor tyrosine kinase genes expressed early and sequentially in the endothelial lineage. In wild-type fish, flk-1-positive cells are found throughout the embryo and differentiate to form the nascent vasculature. In cloche mutants, flk-1-positive cells are found only in the lower trunk and tail regions, and this expression is delayed as compared to wild-type. Unlike the flk-1-positive cells in wild-type embryos, those in cloche mutants do not go on to express tie, suggesting that their differentiation is halted at an early stage. We also find that the cloche mutation is not linked to flk-1. These data indicate that cloche affects the differentiation of all endothelial cells and that it acts at a very early stage, either by directly regulating flk-1 expression or by controlling the differentiation of cells that normally develop to express flk-1. cloche mutants also have a blood deficit and their hematopoietic tissues show no expression of the hematopoietic transcription factor genes GATA-1 or GATA-2 at early stages. Because the appearance of distinct levels of flk-1 expression is delayed in cloche mutants, we examined GATA-1 expression at late embryonic stages and found some blood cell differentiation that appears to be limited to the region lined by the flk-1-expressing cells. The spatial restriction of blood in the ventroposterior-most region of cloche mutant embryos may be indicative of a ventral source of signal(s) controlling hematopoietic differentiation. In addition, the restricted colocalization of blood and endothelium in cloche mutants suggests that important interactions occur between these two lineages during normal development.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Tao, Y. Cai, and K. Sampath The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling Development, August 15, 2009; 136(16): 2757 - 2765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Peterkin, A. Gibson, and R. Patient Common genetic control of haemangioblast and cardiac development in zebrafish Development, May 1, 2009; 136(9): 1465 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Swift and B. M. Weinstein Arterial-Venous Specification During Development Circ. Res., March 13, 2009; 104(5): 576 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Mudumana, D. Hentschel, Y. Liu, A. Vasilyev, and I. A. Drummond odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate Development, October 15, 2008; 135(20): 3355 - 3367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-W. Xiong, Q. Yu, J. Zhang, and J. D. Mably An Acyltransferase Controls the Generation of Hematopoietic and Endothelial Lineages in Zebrafish Circ. Res., May 9, 2008; 102(9): 1057 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-L. Wang, X.-P. Xu, B.-L. He, S.-P. Weng, J. Xiao, L. Wang, T. Lin, X. Liu, Q. Wang, X.-Q. Yu, et al. Infectious Spleen and Kidney Necrosis Virus ORF48R Functions as a New Viral Vascular Endothelial Growth Factor J. Virol., May 1, 2008; 82(9): 4371 - 4383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cermenati, S. Moleri, S. Cimbro, P. Corti, L. Del Giacco, R. Amodeo, E. Dejana, P. Koopman, F. Cotelli, and M. Beltrame Sox18 and Sox7 play redundant roles in vascular development Blood, March 1, 2008; 111(5): 2657 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Esguerra, L. Nelles, L. Vermeire, A. Ibrahimi, A. D. Crawford, R. Derua, E. Janssens, E. Waelkens, P. Carmeliet, D. Collen, et al. Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination Development, December 15, 2007; 134(24): 4381 - 4393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, P. W. Faloon, Z. Tan, Y. Lv, P. Zhang, Y. Ge, H. Deng, and J.-W. Xiong Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation Blood, November 15, 2007; 110(10): 3601 - 3609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. G. Holtzman, J. J. Schoenebeck, H.-J. Tsai, and D. Yelon Endocardium is necessary for cardiomyocyte movement during heart tube assembly Development, June 15, 2007; 134(12): 2379 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pyriochou, D. Beis, V. Koika, C. Potytarchou, E. Papadimitriou, Z. Zhou, and A. Papapetropoulos Soluble Guanylyl Cyclase Activation Promotes Angiogenesis J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 663 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Alt, O. A. Elsalini, P. Schrumpf, N. Haufs, N. D. Lawson, G. C. Schwabe, S. Mundlos, A. Gruters, H. Krude, and K. B. Rohr Arteries define the position of the thyroid gland during its developmental relocalisation. Development, October 1, 2006; 133(19): 3797 - 3804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, J.-W. Xiong, C. S. Shelley, H. Park, and M. A. Arnaout The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells Development, September 15, 2006; 133(18): 3641 - 3650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Mably, L. P. Chuang, F. C. Serluca, M.-A. P. K. Mohideen, J.-N. Chen, and M. C. Fishman santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish Development, August 15, 2006; 133(16): 3139 - 3146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, D. Mukhopadhyay, and X. Xu C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis FASEB J, July 1, 2006; 20(9): 1513 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Leung, H. Chen, A. M. Stauffer, K. E. Giger, S. Sinha, E. J. Horstick, J. E. Humbert, C. A. Hansen, and J. D. Robishaw Zebrafish G protein {gamma}2 is required for VEGF signaling during angiogenesis Blood, July 1, 2006; 108(1): 160 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. D. Covassin, J. A. Villefranc, M. C. Kacergis, B. M. Weinstein, and N. D. Lawson Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish PNAS, April 25, 2006; 103(17): 6554 - 6559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Miano Fishing for Function in Zebrafish Circ. Res., March 31, 2006; 98(6): 723 - 726. [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Jin, D. Beis, T. Mitchell, J.-N. Chen, and D. Y. R. Stainier Cellular and molecular analyses of vascular tube and lumen formation in zebrafish Development, December 1, 2005; 132(23): 5199 - 5209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.E. Ferguson III, R. W. Kelley, and C. Patterson Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2246 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kubota, Y. Oike, S. Satoh, Y. Tabata, Y. Niikura, T. Morisada, M. Akao, T. Urano, Y. Ito, T. Miyamoto, et al. Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development PNAS, September 20, 2005; 102(38): 13502 - 13507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Weber, S. E. Choe, K. A. Dooley, N. N. Paffett-Lugassy, Y. Zhou, and L. I. Zon Mutant-specific gene programs in the zebrafish Blood, July 15, 2005; 106(2): 521 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sumanas, T. Jorniak, and S. Lin Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants Blood, July 15, 2005; 106(2): 534 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yabu, H. Tomimoto, Y. Taguchi, S. Yamaoka, Y. Igarashi, and T. Okazaki Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate Blood, July 1, 2005; 106(1): 125 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lorent, S.-Y. Yeo, T. Oda, S. Chandrasekharappa, A. Chitnis, R. P. Matthews, and M. Pack Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy Development, November 15, 2004; 131(22): 5753 - 5766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gottgens, C. Broccardo, M.-J. Sanchez, S. Deveaux, G. Murphy, J. R. Gothert, E. Kotsopoulou, S. Kinston, L. Delaney, S. Piltz, et al. The scl +18/19 Stem Cell Enhancer Is Not Required for Hematopoiesis: Identification of a 5' Bifunctional Hematopoietic-Endothelial Enhancer Bound by Fli-1 and Elf-1 Mol. Cell. Biol., March 1, 2004; 24(5): 1870 - 1883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Liang, C. A. Jones, B. W. Bisgrove, L. Song, S. T. Glenn, H. J. Yost, and K. W. Gross Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish Physiol Genomics, February 13, 2004; 16(3): 314 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Martin, R. Lahlil, A. Damert, L. Miquerol, A. Nagy, G. Keller, and T. Hoang SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis Development, February 1, 2004; 131(3): 693 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Timmerman, J. Grego-Bessa, A. Raya, E. Bertran, J. M. Perez-Pomares, J. Diez, S. Aranda, S. Palomo, F. McCormick, J. C. Izpisua-Belmonte, et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation Genes & Dev., January 1, 2004; 18(1): 99 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gering, Y. Yamada, T. H. Rabbitts, and R. K. Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1 Development, December 22, 2003; 130(25): 6187 - 6199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Cross, M. A. Cook, S. Lin, J.-N. Chen, and A. L. Rubinstein Rapid Analysis of Angiogenesis Drugs in a Live Fluorescent Zebrafish Assay Arterioscler Thromb Vasc Biol, May 1, 2003; 23(5): 911 - 912. [Full Text] [PDF]
|
|
|
|
|
|
M. L. Kalev-Zylinska, J. A. Horsfield, M. V. C. Flores, J. H. Postlethwait, M. R. Vitas, A. M. Baas, P. S. Crosier, and K. E. Crosier Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis Development, March 6, 2003; 129(8): 2015 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Brutsaert Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity Physiol Rev, January 1, 2003; 83(1): 59 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nemer and M. Nemer Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells Development, September 1, 2002; 129(17): 4045 - 4055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Thisse and L. I. Zon Organogenesis--Heart and Blood Formation from the Zebrafish Point of View Science, January 18, 2002; 295(5554): 457 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Liao, N. S. Trede, D. Ransom, A. Zapata, M. Kieran, and L. I. Zon Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish Development, January 2, 2002; 129(3): 649 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Oates, S. J. Pratt, B. Vail, Y.-l. Yan, R. K. Ho, S. L. Johnson, J. H. Postlethwait, and L. I. Zon The zebrafish klf gene family Blood, September 15, 2001; 98(6): 1792 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Furthauer, F. Reifers, M. Brand, B. Thisse, and C. Thisse sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish Development, June 15, 2001; 128(12): 2175 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Lyons, B. C. Shue, A. C. Oates, L. I. Zon, and P. P. Liu A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain Blood, May 1, 2001; 97(9): 2611 - 2617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Zhong, M. Rosenberg, M. P. Mohideen, B. Weinstein, and M. C. Fishman gridlock, an HLH Gene Required for Assembly of the Aorta in Zebrafish Science, March 10, 2000; 287(5459): 1820 - 1824. [Abstract] [Full Text]
|
|
|
|
|
|
W Liao, C. Ho, Y. Yan, J Postlethwait, and D. Stainier Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish Development, January 10, 2000; 127(20): 4303 - 4313. [Abstract] [PDF]
|
|
|
|
|
|
A. C. Oates, A. Brownlie, S. J. Pratt, D. V. Irvine, E. C. Liao, B. H. Paw, K. J. Dorian, S. L. Johnson, J. H. Postlethwait, L. I. Zon, et al. Gene Duplication of Zebrafish JAK2 Homologs Is Accompanied by Divergent Embryonic Expression Patterns: Only jak2a Is Expressed During Erythropoiesis Blood, October 15, 1999; 94(8): 2622 - 2636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hidaka, W. L. Stanford, and A. Bernstein Conditional requirement for the Flk-1 receptor in the in vitro generation of early hematopoietic cells PNAS, June 22, 1999; 96(13): 7370 - 7375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Begley and A. R. Green The SCL Gene: From Case Report to Critical Hematopoietic Regulator Blood, May 1, 1999; 93(9): 2760 - 2770. [Full Text] [PDF]
|
|
|
|
|
|
C Porcher, E. Liao, Y Fujiwara, L. Zon, and S. Orkin Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding Development, January 10, 1999; 126(20): 4603 - 4615. [Abstract] [PDF]
|
|
|
|
|
|
M Sanchez, B Gottgens, A. Sinclair, M Stanley, C. Begley, S Hunter, and A. Green An SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors Development, January 9, 1999; 126(17): 3891 - 3904. [Abstract] [PDF]
|
|
|
|
|
|
L Parker and D. Stainier Cell-autonomous and non-autonomous requirements for the zebrafish gene cloche in hematopoiesis Development, January 6, 1999; 126(12): 2643 - 2651. [Abstract] [PDF]
|
|
|
|
|
|
S. Connors, J Trout, M Ekker, and M. Mullins The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo Development, January 6, 1999; 126(14): 3119 - 3130. [Abstract] [PDF]
|
|
|
|
|
|
B. Bisgrove, J. Essner, and H. Yost Regulation of midline development by antagonism of lefty and nodal signaling Development, January 6, 1999; 126(14): 3253 - 3262. [Abstract] [PDF]
|
|
|
|
|
|
M.-C. Labastie, F. Cortes, P.-H. Romeo, C. Dulac, and B. Peault Molecular Identity of Hematopoietic Precursor Cells Emerging in the Human Embryo Blood, November 15, 1998; 92(10): 3624 - 3635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Liao, B. H. Paw, A. C. Oates, S. J. Pratt, J. H. Postlethwait, and L. I. Zon SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish Genes & Dev., March 1, 1998; 12(5): 621 - 626. [Abstract] [Full Text]
|
|
