|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 2 399-410, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
V Dupe, M Davenne, J Brocard, P Dolle, M Mark, A Dierich, P Chambon and FM Rijli
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/ULP, College de France, Illkirch, CU de Strasbourg, France.
Retinoids are essential for normal development and both deficiency and excess of retinoic acid (RA) are teratogenic. Retinoic acid response elements (RAREs) have been identified in Hox gene promoters suggesting that endogenous retinoids may be involved in the direct control of Hox gene patterning functions. In order to test this hypothesis, we have mutated the Hoxa-1 3'RARE using the Cre-loxP targeting strategy, and studied its functional role during mouse development. We find that this enhancer plays an important role in the early establishment of the Hoxa-1 anterior expression boundary in the neural plate. This early disturbance in Hoxa-1 activation results in rhombomere and cranial nerve abnormalities reminiscent of those obtained in the Hoxa-1 total knockout, although their severity and penetrance are lower, thus providing strong evidence for direct control of Hox gene function by retinoids during normal development. Interestingly, we also find that the Hoxa-1 expression response to RA treatment is not entirely controlled by the RARE, suggesting the existence of other retinoid-induced factors mediating the Hoxa-1 response to RA and/or the presence of additional RAREs. Interestingly, although the RARE is not required for the spatiotemporal control of colinear expression of the Hoxa genes, it is absolutely required for correct Hoxa-2 expression in rhombomere 5.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Duchon, V. Besson, P. L. Pereira, L. Magnol, and Y. Herault Inducing Segmental Aneuploid Mosaicism in the Mouse Through Targeted Asymmetric Sister Chromatid Event of Recombination Genetics, September 1, 2008; 180(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Lapinski, J. A. Oliver, L. A. Kamen, E. D. Hughes, T. L. Saunders, and P. D. King Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to T Cell-Specific Adapter and Adapter Protein in Lymphocytes of Unknown Function, Reveals a Redundant Function in T Cells J. Immunol., August 1, 2008; 181(3): 2019 - 2027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Essalmani, A. Zaid, J. Marcinkiewicz, A. Chamberland, A. Pasquato, N. G. Seidah, and A. Prat In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate PNAS, April 15, 2008; 105(15): 5750 - 5755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ryckebusch, Z. Wang, N. Bertrand, S.-C. Lin, X. Chi, R. Schwartz, S. Zaffran, and K. Niederreither Retinoic acid deficiency alters second heart field formation PNAS, February 26, 2008; 105(8): 2913 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. MacLean, H. Li, D. Metzger, P. Chambon, and M. Petkovich Apoptotic Extinction of Germ Cells in Testes of Cyp26b1 Knockout Mice Endocrinology, October 1, 2007; 148(10): 4560 - 4567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Besson, V. Brault, A. Duchon, D. Togbe, J.-C. Bizot, V. F.J. Quesniaux, B. Ryffel, and Y. Herault Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses Hum. Mol. Genet., September 1, 2007; 16(17): 2040 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Pilon, K. Oh, J.-R. Sylvestre, J. G. A. Savory, and D. Lohnes Wnt signaling is a key mediator of Cdx1 expression in vivo Development, June 15, 2007; 134(12): 2315 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tarrade, C. Fassier, S. Courageot, D. Charvin, J. Vitte, L. Peris, A. Thorel, E. Mouisel, N. Fonknechten, N. Roblot, et al. A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition Hum. Mol. Genet., December 15, 2006; 15(24): 3544 - 3558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Germain, P. Chambon, G. Eichele, R. M. Evans, M. A. Lazar, M. Leid, A. R. De Lera, R. Lotan, D. J. Mangelsdorf, and H. Gronemeyer International Union of Pharmacology. LX. Retinoic Acid Receptors Pharmacol. Rev., December 1, 2006; 58(4): 712 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kobrossy, M. Rastegar, and M. Featherstone Interplay between Chromatin and Trans-acting Factors Regulating the Hoxd4 Promoter during Neural Differentiation J. Biol. Chem., September 8, 2006; 281(36): 25926 - 25939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Liu The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord Development, August 1, 2006; 133(15): 2865 - 2874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-S. Cho, E.-J. Kim, U.-H. Park, H.-S. Sin, and S.-J. Um Additional Sex Comb-like 1 (ASXL1), in Cooperation with SRC-1, Acts as a Ligand-dependent Coactivator for Retinoic Acid Receptor J. Biol. Chem., June 30, 2006; 281(26): 17588 - 17598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tan, N. Dourdin, C. Wu, T. De Veyra, J. S. Elce, and P. A. Greer Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis J. Biol. Chem., June 9, 2006; 281(23): 16016 - 16024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Essalmani, J. Hamelin, J. Marcinkiewicz, A. Chamberland, M. Mbikay, M. Chretien, N. G. Seidah, and A. Prat Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse Mol. Cell. Biol., January 1, 2006; 26(1): 354 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Monier, M. Astier, M. Semeriva, and L. Perrin Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart Development, December 1, 2005; 132(23): 5283 - 5293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Santagati, M. Minoux, S.-Y. Ren, and F. M. Rijli Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis Development, November 15, 2005; 132(22): 4927 - 4936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Martinez-Ceballos, P. Chambon, and L. J. Gudas Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal J. Biol. Chem., April 22, 2005; 280(16): 16484 - 16498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tabaries, J. Lapointe, T. Besch, M. Carter, J. Woollard, C. K. Tuggle, and L. Jeannotte Cdx Protein Interaction with Hoxa5 Regulatory Sequences Contributes to Hoxa5 Regional Expression along the Axial Skeleton Mol. Cell. Biol., February 15, 2005; 25(4): 1389 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Serpente, S. Tumpel, N. B. Ghyselinck, K. Niederreither, L. M. Wiedemann, P. Dolle, P. Chambon, R. Krumlauf, and A. P. Gould Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation Development, February 1, 2005; 132(3): 503 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Mellitzer, M. Martin, M. Sidhoum-Jenny, C. Orvain, J. Barths, P. A. Seymour, M. Sander, and G. Gradwohl Pancreatic Islet Progenitor Cells in Neurogenin 3-Yellow Fluorescent Protein Knock-Add-On Mice Mol. Endocrinol., November 1, 2004; 18(11): 2765 - 2776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rastegar, L. Kobrossy, E. N. Kovacs, I. Rambaldi, and M. Featherstone Sequential Histone Modifications at Hoxd4 Regulatory Regions Distinguish Anterior from Posterior Embryonic Compartments Mol. Cell. Biol., September 15, 2004; 24(18): 8090 - 8103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Hernandez, H. A. Rikhof, R. Bachmann, and C. B. Moens vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish Development, September 15, 2004; 131(18): 4511 - 4520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shiotsugu, Y. Katsuyama, K. Arima, A. Baxter, T. Koide, J. Song, R. A. S. Chandraratna, and B. Blumberg Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation Development, June 1, 2004; 131(11): 2653 - 2667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Houle, J.-R. Sylvestre, and D. Lohnes Retinoic acid regulates a subset of Cdx1 function in vivo Development, December 29, 2003; 130(26): 6555 - 6567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gavalas, C. Ruhrberg, J. Livet, C. E. Henderson, and R. Krumlauf Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes Development, December 1, 2003; 130(23): 5663 - 5679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dupe, N. Matt, J.-M. Garnier, P. Chambon, M. Mark, and N. B. Ghyselinck A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment PNAS, November 25, 2003; 100(24): 14036 - 14041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Juan and F. H. Ruddle Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer Development, October 15, 2003; 130(20): 4823 - 4834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Mohan II, E. Scheer, O. Wendling, D. Metzger, and L. Tora TAF10 (TAFII30) Is Necessary for TFIID Stability and Early Embryogenesis in Mice Mol. Cell. Biol., June 15, 2003; 23(12): 4307 - 4318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bel-Vialar, N. Itasaki, and R. Krumlauf Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups Development, March 13, 2003; 129(22): 5103 - 5115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Weber, F. Cammas, C. Gerard, D. Metzger, P. Chambon, R. Losson, and M. Mark Germ cell expression of the transcriptional co-repressor TIF1{beta} is required for the maintenance of spermatogenesis in the mouse Development, March 7, 2003; 129(10): 2329 - 2337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. McClintock, M. A. Kheirbek, and V. E. Prince Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention Development, March 7, 2003; 129(10): 2339 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Weber, M. Schuler, C. Gerard, M. Mark, D. Metzger, and P. Chambon Temporally Controlled Site-Specific Mutagenesis in the Germ Cell Lineage of the Mouse Testis Biol Reprod, February 1, 2003; 68(2): 553 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gehin, M. Mark, C. Dennefeld, A. Dierich, H. Gronemeyer, and P. Chambon The Function of TIF2/GRIP1 in Mouse Reproduction Is Distinct from Those of SRC-1 and p/CIP Mol. Cell. Biol., August 15, 2002; 22(16): 5923 - 5937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kmita, B. Tarchini, D. Duboule, and Y. Herault Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells Development, January 12, 2002; 129(23): 5521 - 5528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Pitera, V. V. Smith, A. S. Woolf, and P. J. Milla Embryonic Gut Anomalies in a Mouse Model of Retinoic Acid-Induced Caudal Regression Syndrome : Delayed Gut Looping, Rudimentary Cecum, and Anorectal Anomalies Am. J. Pathol., December 1, 2001; 159(6): 2321 - 2329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Manzanares, S. Bel-Vialar, L. Ariza-McNaughton, E. Ferretti, H. Marshall, M. M. Maconochie, F. Blasi, and R. Krumlauf Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms Development, September 15, 2001; 128(18): 3595 - 3607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Begemann, T. F. Schilling, G.-J. Rauch, R. Geisler, and P. W. Ingham The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain Development, August 15, 2001; 128(16): 3081 - 3094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dupe and A. Lumsden Hindbrain patterning involves graded responses to retinoic acid signalling Development, June 15, 2001; 128(12): 2199 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Abu-Abed, P. Dollé, D. Metzger, B. Beckett, P. Chambon, and M. Petkovich The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures Genes & Dev., January 15, 2001; 15(2): 226 - 240. [Abstract] [Full Text]
|
|
|
|
|
|
M Li, H Chiba, X Warot, N Messaddeq, C Gerard, P Chambon, and D Metzger RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations Development, January 3, 2001; 128(5): 675 - 688. [Abstract] [PDF]
|
|
|
|
|
|
M. Houle, P. Prinos, A. Iulianella, N. Bouchard, and D. Lohnes Retinoic Acid Regulation of Cdx1: an Indirect Mechanism for Retinoids and Vertebral Specification Mol. Cell. Biol., September 1, 2000; 20(17): 6579 - 6586. [Abstract] [Full Text]
|
|
|
|
|
|
T. Frugier, F. D. Tiziano, C. Cifuentes-Diaz, P. Miniou, N. Roblot, A. Dierich, M. Le Meur, and J. Melki Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy Hum. Mol. Genet., March 22, 2000; 9(5): 849 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kmita, F. van der Hoeven, J. Zákány, R. Krumlauf, and D. Duboule Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex Genes & Dev., January 15, 2000; 14(2): 198 - 211. [Abstract] [Full Text]
|
|
|
|
|
|
S Dupont, A Krust, A Gansmuller, A Dierich, P Chambon, and M Mark Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes Development, January 10, 2000; 127(19): 4277 - 4291. [Abstract] [PDF]
|
|
|
|
|
|
F Cammas, M Mark, P Dolle, A Dierich, P Chambon, and R Losson Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development Development, January 7, 2000; 127(13): 2955 - 2963. [Abstract] [PDF]
|
|
|
|
|
|
O Wendling, C Dennefeld, P Chambon, and M Mark Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches Development, January 4, 2000; 127(8): 1553 - 1562. [Abstract] [PDF]
|
|
|
|
|
|
E Ferretti, H Marshall, H Popperl, M Maconochie, R Krumlauf, and F Blasi Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins Development, January 1, 2000; 127(1): 155 - 166. [Abstract] [PDF]
|
|
|
|
|
|
C Irving and I Mason Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression Development, January 1, 2000; 127(1): 177 - 186. [Abstract] [PDF]
|
|
|
|
|
|
M Manzanares, S Cordes, L Ariza-McNaughton, V Sadl, K Maruthainar, G Barsh, and R Krumlauf Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes Development, January 2, 1999; 126(4): 759 - 769. [Abstract] [PDF]
|
|
|
|
|
|
J. C. White, V. N. Shankar, M. Highland, M. L. Epstein, H. F. DeLuca, and M. Clagett-Dame Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid PNAS, November 10, 1998; 95(23): 13459 - 13464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Mascrez, M Mark, A Dierich, N. Ghyselinck, P Kastner, and P Chambon The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development Development, January 12, 1998; 125(23): 4691 - 4707. [Abstract] [PDF]
|
|
|
|
|
|
F Helmbacher, C Pujades, C Desmarquet, M Frain, F. Rijli, P Chambon, and P Charnay Hoxa1 and Krox-20 synergize to control the development of rhombomere 3 Development, January 12, 1998; 125(23): 4739 - 4748. [Abstract] [PDF]
|
|
|
|
|
|
D Huang, S. Chen, A. Langston, and L. Gudas A conserved retinoic acid responsive element in the murine Hoxb-1 gene is required for expression in the developing gut Development, January 8, 1998; 125(16): 3235 - 3246. [Abstract] [PDF]
|
|
|
|
|
|
A. Packer, D. Crotty, V. Elwell, and D. Wolgemuth Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element Development, January 6, 1998; 125(11): 1991 - 1998. [Abstract] [PDF]
|
|
|
|
|
|
Y Herault, J Beckers, T Kondo, N Fraudeau, and D Duboule Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex Development, January 5, 1998; 125(9): 1669 - 1677. [Abstract] [PDF]
|
|
|
|
|
|
M Studer, A Gavalas, H Marshall, L Ariza-McNaughton, F. Rijli, P Chambon, and R Krumlauf Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning Development, January 3, 1998; 125(6): 1025 - 1036. [Abstract] [PDF]
|
|
|
|
|
|
A Gavalas, M Studer, A Lumsden, F. Rijli, R Krumlauf, and P Chambon Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch Development, January 3, 1998; 125(6): 1123 - 1136. [Abstract] [PDF]
|
|
|
|
|
|
J van der Wees, J. Schilthuis, C. Koster, H Diesveld-Schipper, G. Folkers, P. van der Saag, M. Dawson, K Shudo, B van der Burg, and A. Durston Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain Development, January 2, 1998; 125(3): 545 - 556. [Abstract] [PDF]
|
|
|
|
|
|
M K Maconochie, S Nonchev, M Studer, S K Chan, H Popperl, M H Sham, R S Mann, and R Krumlauf Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes & Dev., July 15, 1997; 11(14): 1885 - 1895. [Abstract] [PDF]
|
|
|
|
|
|
A Gavalas, M Davenne, A Lumsden, P Chambon, and F. Rijli Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning Development, January 10, 1997; 124(19): 3693 - 3702. [Abstract] [PDF]
|
|
|
|
|
|
A Morrison, L Ariza-McNaughton, A Gould, M Featherstone, and R Krumlauf HOXD4 and regulation of the group 4 paralog genes Development, January 8, 1997; 124(16): 3135 - 3146. [Abstract] [PDF]
|
|
|
|
|
|
M Maden, A Graham, E Gale, C Rollinson, and M Zile Positional apoptosis during vertebrate CNS development in the absence of endogenous retinoids Development, January 7, 1997; 124(14): 2799 - 2805. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Rossant, B. Ciruna, and J. Partanen FGF Signaling in Mouse Gastrulation and Anteroposterior Patterning Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 127 - 133. [Abstract] [PDF]
|
|
|
|
|
|
P. J. Kolm and H. L. Sive Retinoids and Posterior Neural Induction: A Reevaluation of Nieuwkoop's Two-step Hypothesis Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 511 - 521. [Abstract] [PDF]
|
|
|
|
|
|
G. Di Rocco, A. Gavalas, H. Popperl, R. Krumlauf, F. Mavilio, and V. Zappavigna The Recruitment of SOX/OCT Complexes and the Differential Activity of HOXA1 and HOXB1 Modulate the Hoxb1 Auto-regulatory Enhancer Function J. Biol. Chem., June 1, 2001; 276(23): 20506 - 20515. [Abstract] [Full Text] [PDF]
|
|
