|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 2 559-567, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
F Chanut and U Heberlein
Department of Neurology, University of California San Francisco, 94110, USA. chanut@itsa.ucsf.edu
Morphogenesis in the Drosophila retina initiates at the posterior margin of the eye imaginal disc by an unknown mechanism. Upon initiation, a wave of differentiation, its forward edge marked by the morphogenetic furrow (MF), proceeds anteriorly across the disc. Progression of the MF is driven by hedgehog (hh), expressed by differentiating photoreceptor cells. The TGF-beta homolog encoded by decapentaplegic (dpp) is expressed at the disc's posterior margin prior to initiation and in the furrow, under the control of hh, during MF progression. While dpp has been implicated in eye disc growth and morphogenesis, its precise role in retinal differentiation has not been determined. To address the role of dpp in initiation and progression of retinal differentiation we analyzed the consequences of reduced and increased dpp function during eye development. We find that dpp is not only required for normal MF initiation, but is sufficient to induce ectopic initiation of differentiation. Inappropriate initiation is normally inhibited by wingless (wg). Loss of dpp function is accompanied by expansion of wg expression, while increased dpp function leads to loss of wg transcription. In addition, dpp is required to maintain, and sufficient to induce, its own expression along the disc's margins. We postulate that dpp autoregulation and dpp-mediated inhibition of wg expression are required for the coordinated regulation of furrow initiation and progression. Finally, we show that in the later stages of retinal differentiation, reduction of dpp function leads to an arrest in MF progression.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  L. R. Braid and E. M. Verheyen Drosophila Nemo Promotes Eye Specification Directed by the Retinal Determination Gene Network Genetics, September 1, 2008; 180(1): 283 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Subramanian, S. Hegde, P. Porayette, M. Yon, P. Hankey, and R. F. Paulson Friend Virus Utilizes the BMP4-Dependent Stress Erythropoiesis Pathway To Induce Erythroleukemia J. Virol., January 1, 2008; 82(1): 382 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lee, B. G. Stultz, and D. A. Hursh The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development Development, April 1, 2007; 134(7): 1301 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Ekas, G.-H. Baeg, M. S. Flaherty, A. Ayala-Camargo, and E. A. Bach JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila Development, December 1, 2006; 133(23): 4721 - 4729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rogers, C. A. Brennan, N. T. Mortimer, S. Cook, A. R. Morris, and K. Moses Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow Development, November 1, 2005; 132(21): 4833 - 4843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Pappu, E. J. Ostrin, B. W. Middlebrooks, B. T. Sili, R. Chen, M. R. Atkins, R. Gibbs, and G. Mardon Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund Development, June 15, 2005; 132(12): 2895 - 2905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pauli, M. Seimiya, J. Blanco, and W. J. Gehring Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog Development, June 15, 2005; 132(12): 2771 - 2782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lim and K.-W. Choi Bar homeodomain proteins are anti-proneural in the Drosophila eye: transcriptional repression of atonal by Bar prevents ectopic retinal neurogenesis Development, December 15, 2003; 130(24): 5965 - 5974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thomas and P. W. Ingham Hedgehog Signaling in the Drosophila Eye and Head: An Analysis of the Effects of Different patched Trans-heterozygotes Genetics, December 1, 2003; 165(4): 1915 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Friedrich Evolution of Insect Eye Development: First Insights from Fruit Fly, Grasshopper and Flour Beetle Integr. Comp. Biol., August 1, 2003; 43(4): 508 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. Lin, D. B. Doroquez, S. Cho, F. Chen, I. Rebay, and K. M. Cadigan Splits ends is a tissue/promoter specific regulator of Wingless signaling Development, July 15, 2003; 130(14): 3125 - 3135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development Development, July 1, 2003; 130(13): 2939 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Pappu, R. Chen, B. W. Middlebrooks, C. Woo, U. Heberlein, and G. Mardon Mechanism of hedgehog signaling during Drosophila eye development Development, July 1, 2003; 130(13): 3053 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ghosh-Choudhury, S. L. Abboud, L. Mahimainathan, B. Chandrasekar, and G. G. Choudhury Phosphatidylinositol 3-Kinase Regulates Bone Morphogenetic Protein-2 (BMP-2)-induced Myocyte Enhancer Factor 2A-dependent Transcription of BMP-2 Gene in Cardiomyocyte Precursor Cells J. Biol. Chem., June 6, 2003; 278(24): 21998 - 22005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Cadigan, A. D. Jou, and R. Nusse Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless Development, March 9, 2003; 129(14): 3393 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bessa, B. Gebelein, F. Pichaud, F. Casares, and R. S. Mann Combinatorial control of Drosophila eye development by Eyeless, Homothorax, and Teashirt Genes & Dev., September 15, 2002; 16(18): 2415 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hsiung and K. Moses Retinal development in Drosophila: specifying the first neuron Hum. Mol. Genet., May 15, 2002; 11(10): 1207 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Chanut, K. Woo, S. Pereira, T. J. Donohoe, S.-Y. Chang, T. R. Laverty, A. P. Jarman, and U. Heberlein Rough eye Is a Gain-of-Function Allele of amos That Disrupts Regulation of the Proneural Gene atonal During Drosophila Retinal Differentiation Genetics, February 1, 2002; 160(2): 623 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baonza and M. Freeman Control of Drosophila eye specification by Wingless signalling Development, January 12, 2002; 129(23): 5313 - 5322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Kumar and K. Moses The EGF receptor and notch signaling pathways control the initiation of the morphogenetic furrow during Drosophila eye development Development, July 15, 2001; 128(14): 2689 - 2697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lee and J. Treisman The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc Development, January 5, 2001; 128(9): 1519 - 1529. [Abstract] [PDF]
|
|
|
|
|
|
J Treisman Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development Development, January 2, 2001; 128(4): 603 - 615. [Abstract] [PDF]
|
|
|
|
|
|
F. Chanut, A. Luk, and U. Heberlein A Screen for Dominant Modifiers of roDom, a Mutation That Disrupts Morphogenetic Furrow Progression in Drosophila, Identifies Groucho and Hairless as Regulators of atonal Expression Genetics, November 1, 2000; 156(3): 1203 - 1217. [Abstract] [Full Text]
|
|
|
|
|
|
J Curtiss and M Mlodzik Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent Development, January 3, 2000; 127(6): 1325 - 1336. [Abstract] [PDF]
|
|
|
|
|
|
S Greenwood and G Struhl Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway Development, January 12, 1999; 126(24): 5795 - 5808. [Abstract] [PDF]
|
|
|
|
|
|
F Cavodeassi, R Diez Del Corral, S Campuzano, and M Dominguez Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins Development, January 11, 1999; 126(22): 4933 - 4942. [Abstract] [PDF]
|
|
|
|
|
|
J Hepker, R. Blackman, and R Holmgren Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer Development, January 8, 1999; 126(16): 3669 - 3677. [Abstract] [PDF]
|
|
|
|
|
|
R Chen, G Halder, Z Zhang, and G Mardon Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila Development, January 2, 1999; 126(5): 935 - 943. [Abstract] [PDF]
|
|
|
|
|
|
Y. Furuta and B. L.M. Hogan BMP4 is essential for lens induction in the mouse embryo Genes & Dev., December 1, 1998; 12(23): 3764 - 3775. [Abstract] [Full Text]
|
|
|
|
|
|
C.-Y. Pai, T.-S. Kuo, T. J. Jaw, E. Kurant, C.-T. Chen, D. A. Bessarab, A. Salzberg, and Y. H. Sun The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila Genes & Dev., February 1, 1998; 12(3): 435 - 446. [Abstract] [Full Text]
|
|
|
|
|
|
J Horsfield, A Penton, J Secombe, F. Hoffman, and H Richardson decapentaplegic is required for arrest in G1 phase during Drosophila eye development Development, January 12, 1998; 125(24): 5069 - 5078. [Abstract] [PDF]
|
|
|
|
|
|
D. Hazelett, M Bourouis, U Walldorf, and J. Treisman decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc Development, January 9, 1998; 125(18): 3741 - 3751. [Abstract] [PDF]
|
|
|
|
|
|
C. Brennan, M Ashburner, and K Moses Ecdysone pathway is required for furrow progression in the developing Drosophila eye Development, January 7, 1998; 125(14): 2653 - 2664. [Abstract] [PDF]
|
|
|
|
|
|
P Das, L. Maduzia, H Wang, A. Finelli, S. Cho, M. Smith, and R. Padgett The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling Development, January 4, 1998; 125(8): 1519 - 1528. [Abstract] [PDF]
|
|
|
|
|
|
E Kurant, C. Pai, R Sharf, N Halachmi, Y. Sun, and A Salzberg Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS Development, January 3, 1998; 125(6): 1037 - 1048. [Abstract] [PDF]
|
|
|
|
|
|
U Heberlein, E. Borod, and F. Chanut Dorsoventral patterning in the Drosophila retina by wingless Development, January 2, 1998; 125(4): 567 - 577. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Treisman, A. Luk, G. M. Rubin, and U. Heberlein eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins Genes & Dev., August 1, 1997; 11(15): 1949 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Royet and R Finkelstein Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog Development, January 12, 1997; 124(23): 4793 - 4800. [Abstract] [PDF]
|
|
|
|
|
|
S. Jackson, H Nakato, M Sugiura, A Jannuzi, R Oakes, V Kaluza, C Golden, and S. Selleck dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp Development, January 10, 1997; 124(20): 4113 - 4120. [Abstract] [PDF]
|
|
|
|
|
|
D. Strutt and M Mlodzik Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc Development, January 9, 1997; 124(17): 3233 - 3240. [Abstract] [PDF]
|
|
