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Development, Vol 124, Issue 20 4065-4075, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
A Pattyn, X Morin, H Cremer, C Goridis and JF Brunet
Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS/INSERM/Universite de la Mediterranee, France.
Recent evidence suggests that specific families of homeodomain transcription factors control the generation and survival of distinct neuronal types. We had previously characterized the homeobox gene Phox2a, which is expressed in differentiating neurons of the central and peripheral autonomic nervous system as well as in motor nuclei of the hindbrain. Targeted deletion of the Phox2a gene affects part of the structures in which it is expressed: the locus coeruleus, visceral sensory and parasympathetic ganglia and, as we show here, the nuclei of the IIIrd and IVth cranial nerves. We now report on the characterization of Phox2b, a close relative of Phox2a, with an identical homeodomain. Phox2a and Phox2b are co-expressed at most sites, therefore suggesting a broader role for Phox2 genes in the specification of the autonomic nervous system and cranial motor nuclei than revealed by the Phox2a knock-out mice. A detailed analysis of the relative timing of Phox2a and Phox2b expression at various sites suggests positive cross-regulations, which are substantiated by the loss of Phox2b expression in cranial ganglia of Phox2a-deficient mice. In the major part of the rhombencephalon, Phox2b expression precedes that of Phox2a and starts in the proliferative neuroepithelium, in a pattern strikingly restricted on the dorsoventral axis and at rhombomeric borders. This suggests that Phox2b links early patterning events to the differentiation of defined neuronal populations in the hindbrain.
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M. L. Bilodeau, T. Boulineau, R. L. Hullinger, and O. M. Andrisani Cyclic AMP Signaling Functions as a Bimodal Switch in Sympathoadrenal Cell Development in Cultured Primary Neural Crest Cells Mol. Cell. Biol., May 1, 2000; 20(9): 3004 - 3014. [Abstract] [Full Text]
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V Dubreuil, M Hirsch, A Pattyn, J Brunet, and C Goridis The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity Development, January 12, 2000; 127(23): 5191 - 5201. [Abstract] [PDF]
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S Garel, M Garcia-Dominguez, and P Charnay Control of the migratory pathway of facial branchiomotor neurones Development, January 12, 2000; 127(24): 5297 - 5307. [Abstract] [PDF]
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G. Gaufo, P Flodby, and M. Capecchi Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways Development, January 12, 2000; 127(24): 5343 - 5354. [Abstract] [PDF]
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H Enomoto, R. Heuckeroth, J. Golden, E. Johnson, and J Milbrandt Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin Development, January 11, 2000; 127(22): 4877 - 4889. [Abstract] [PDF]
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N Pujol, P Torregrossa, J. Ewbank, and J. Brunet The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans Development, January 8, 2000; 127(15): 3361 - 3371. [Abstract] [PDF]
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A Pattyn, M Hirsch, C Goridis, and J. Brunet Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b Development, January 4, 2000; 127(7): 1349 - 1358. [Abstract] [PDF]
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T. Hendricks, N. Francis, D. Fyodorov, and E. S. Deneris The ETS Domain Factor Pet-1 Is an Early and Precise Marker of Central Serotonin Neurons and Interacts with a Conserved Element in Serotonergic Genes J. Neurosci., December 1, 1999; 19(23): 10348 - 10356. [Abstract] [Full Text] [PDF]
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M Stanke, D Junghans, M Geissen, C Goridis, U Ernsberger, and H Rohrer The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons Development, January 9, 1999; 126(18): 4087 - 4094. [Abstract] [PDF]
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S Taraviras, C. Marcos-Gutierrez, P Durbec, H Jani, M Grigoriou, M Sukumaran, L. Wang, M Hynes, G Raisman, and V Pachnis Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system Development, January 6, 1999; 126(12): 2785 - 2797. [Abstract] [PDF]
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H.-S. Kim, H. Seo, C. Yang, J.-F. Brunet, and K.-S. Kim Noradrenergic-Specific Transcription of the Dopamine beta -Hydroxylase Gene Requires Synergy of Multiple Cis-Acting Elements Including at Least Two Phox2a-Binding Sites J. Neurosci., October 15, 1998; 18(20): 8247 - 8260. [Abstract] [Full Text] [PDF]
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N. Spassky, C. Goujet-Zalc, E. Parmantier, C. Olivier, S. Martinez, A. Ivanova, K. Ikenaka, W. Macklin, I. Cerruti, B. Zalc, et al. Multiple Restricted Origin of Oligodendrocytes J. Neurosci., October 15, 1998; 18(20): 8331 - 8343. [Abstract] [Full Text] [PDF]
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C. Logan, R. J. T. Wingate, I. J. McKay, and A. Lumsden Tlx-1 and Tlx-3 Homeobox Gene Expression in Cranial Sensory Ganglia and Hindbrain of the Chick Embryo: Markers of Patterned Connectivity J. Neurosci., July 15, 1998; 18(14): 5389 - 5402. [Abstract] [Full Text] [PDF]
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M. Hirsch, M. Tiveron, F Guillemot, J. Brunet, and C Goridis Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system Development, January 2, 1998; 125(4): 599 - 608. [Abstract] [PDF]
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L Lo, M. Tiveron, and D. Anderson MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity Development, January 2, 1998; 125(4): 609 - 620. [Abstract] [PDF]
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C. Brodski, H. Schnurch, and G. Dechant Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons PNAS, August 15, 2000; 97(17): 9683 - 9688. [Abstract] [Full Text] [PDF]
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