|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 20 4089-4104, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
L Mathis, C Bonnerot, L Puelles and JF Nicolas
Unite de Biologie moleculaire du Developpement, Institut Pasteur, Paris, France.
Analysis of lacZ neuronal clones in the mouse cerebellum demonstrates genealogical independence of the primary and secondary germinal epithelia (PGE and SGE) from early development. PGE precursors and their neuronal descendants are organised into two polyclonal groups of similar sizes that exhibit parasagittal patterning and generally respect the midline. The relationship between these two groups cannot be traced back in time to less than 80 independent cells, which were probably recruited following a period of non-coherent growth that distributes unrelated cells into distinct territories of the neural tube. A lateromedial clonal organisation is observed in the mature cerebellum, suggesting the existence of many small parasagittal domains of clonal restriction and/or of cell dispersion in the rostrocaudal but not in the mediolateral dimension. The organisation is orthogonal with respect to the cellular organisation in the neural tube as is the genetic organisation. Cellular and genetic patterning of the cerebellum therefore share similarities. A possible hypothesis is that distinct cell behaviours create the different clonal domains observed in this study and that the cellular and genetic organisation of the cerebellum are coordinated.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Leto, A. Bartolini, Y. Yanagawa, K. Obata, L. Magrassi, K. Schilling, and F. Rossi Laminar Fate and Phenotype Specification of Cerebellar GABAergic Interneurons J. Neurosci., May 27, 2009; 29(21): 7079 - 7091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Carletti and F. Rossi Neurogenesis in the Cerebellum Neuroscientist, February 1, 2008; 14(1): 91 - 100. [Abstract] [PDF]
|
|
|
|
|
|
M. Pasqualetti, C. Diaz, J.-S. Renaud, F. M. Rijli, and J. C. Glover Fate-Mapping the Mammalian Hindbrain: Segmental Origins of Vestibular Projection Neurons Assessed Using Rhombomere-Specific Hoxa2 Enhancer Elements in the Mouse Embryo J. Neurosci., September 5, 2007; 27(36): 9670 - 9681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Leto, B. Carletti, I. M. Williams, L. Magrassi, and F. Rossi Different Types of Cerebellar GABAergic Interneurons Originate from a Common Pool of Multipotent Progenitor Cells. J. Neurosci., November 8, 2006; 26(45): 11682 - 11694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Englund, T. Kowalczyk, R. A. M. Daza, A. Dagan, C. Lau, M. F. Rose, and R. F. Hevner Unipolar Brush Cells of the Cerebellum Are Produced in the Rhombic Lip and Migrate through Developing White Matter J. Neurosci., September 6, 2006; 26(36): 9184 - 9195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hashimoto and K. Mikoshiba Mediolateral Compartmentalization of the Cerebellum Is Determined on the "Birth Date" of Purkinje Cells J. Neurosci., December 10, 2003; 23(36): 11342 - 11351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Louvi, P. Alexandre, C. Metin, W. Wurst, and M. Wassef The isthmic neuroepithelium is essential for cerebellar midline fusion Development, November 15, 2003; 130(22): 5319 - 5330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Hendricks, K. H. Almeida, M. S. Stitt, V. S. Jonnalagadda, R. E. Rugo, G. F. Kerrison, and B. P. Engelward Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice PNAS, May 27, 2003; 100(11): 6325 - 6330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Wilkie, S. A. Jordan, and I. J. Jackson Neural crest progenitors of the melanocyte lineage: coat colour patterns revisited Development, March 9, 2003; 129(14): 3349 - 3357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Carletti, P. Grimaldi, L. Magrassi, and F. Rossi Specification of Cerebellar Progenitors After Heterotopic-Heterochronic Transplantation to the Embryonic CNS In Vivo and In Vitro J. Neurosci., August 15, 2002; 22(16): 7132 - 7146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Martin, S.-S. Tan, and D. Goldowitz Clonal Architecture of the Mouse Hippocampus J. Neurosci., May 1, 2002; 22(9): 3520 - 3530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Karam, R. C. Burrows, C. Logan, S. Koblar, E. B. Pasquale, and M. Bothwell Eph Receptors and Ephrins in the Developing Chick Cerebellum: Relationship to Sagittal Patterning and Granule Cell Migration J. Neurosci., September 1, 2000; 20(17): 6488 - 6500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Alcantara, M Ruiz, F De Castro, E Soriano, and C Sotelo Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system Development, January 4, 2000; 127(7): 1359 - 1372. [Abstract] [PDF]
|
|
|
|
|
|
L Mathis and J. Nicolas Different clonal dispersion in the rostral and caudal mouse central nervous system Development, January 3, 2000; 127(6): 1277 - 1290. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Shiojiri, M. Sano, S. Inujima, M. Nitou, M. Kanazawa, and M. Mori Quantitative Analysis of Cell Allocation During Liver Development, Using the spfash-Heterozygous Female Mouse Am. J. Pathol., January 1, 2000; 156(1): 65 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Mathis, J Sieur, O Voiculescu, P Charnay, and J. Nicolas Successive patterns of clonal cell dispersion in relation to neuromeric subdivision in the mouse neuroepithelium Development, January 9, 1999; 126(18): 4095 - 4106. [Abstract] [PDF]
|
|
|
|
|
|
S. L. Baader, S. Sanlioglu, A. S. Berrebi, J. Parker-Thornburg, and J. Oberdick Ectopic Overexpression of Engrailed-2 in Cerebellar Purkinje Cells Causes Restricted Cell Loss and Retarded External Germinal Layer Development at Lobule Junctions J. Neurosci., March 1, 1998; 18(5): 1763 - 1773. [Abstract] [Full Text] [PDF]
|
|
