spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rudolph, K. M.
Right arrow Articles by Lengyel, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rudolph, K. M.
Right arrow Articles by Lengyel, J. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 124, Issue 21 4297-4308, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Complex regulatory region mediating tailless expression in early embryonic patterning and brain development

KM Rudolph, GJ Liaw, A Daniel, P Green, AJ Courey, V Hartenstein and JA Lengyel
Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095-1606, USA.

tailless encodes a transcription factor expressed in multiple domains in the developing embryo. Early and transient expression at the posterior pole is required to establish a domain from which the eighth abdominal segment, telson and posterior gut arise. Just a few nuclear cycles later, a brain-specific domain is initiated at the anterior; expression in this domain is maintained with complex modulations throughout embryogenesis. Expression of tailless in this domain is required to establish the most anterior region of the brain. To understand the function and regulation of these different domains of expression, we provide a detailed description of tailless expression in brain neuroblasts and show that this expression is not detectably regulated by the head gap genes buttonhead or orthodenticle, by the proneural gene lethal of scute or by tailless itself. We show that approximately 6 kb of sequenced upstream regulatory DNA can drive lacZ expression in a pattern that mimics the full tailless embryonic expression pattern. Within this sequence we identify multiple modules responsible for different aspects of the tailless pattern. In addition to identifying additional torso response elements that mediate early blastoderm polar expression, we show that the complex brain expression pattern is driven by a combination of modules; thus expression at a low level throughout the brain and at a high level in the dorsal medial portion of the brain and in the optic lobe, as well as neuroblast-specific repression are mediated by different DNA regions.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
E. Moran and G. Jimenez
The tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryo.
Mol. Cell. Biol., May 1, 2006; 26(9): 3446 - 3454.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Deshpande, G. Calhoun, and P. Schedl
Overlapping mechanisms function to establish transcriptional quiescence in the embryonic Drosophila germline
Development, March 15, 2004; 131(6): 1247 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris
Specification of the vertebrate eye by a network of eye field transcription factors
Development, November 1, 2003; 130(21): 5155 - 5167.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Urbach and G. M. Technau
Segment polarity and DV patterning gene expression reveals segmental organization of the Drosophila brain
Development, August 15, 2003; 130(16): 3607 - 3620.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Urbach and G. M. Technau
Molecular markers for identified neuroblasts in the developing brain of Drosophila
Development, August 15, 2003; 130(16): 3621 - 3637.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. X. Li, H. Agaisse, B. Mathey-Prevot, and N. Perrimon
Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila
Development, March 11, 2003; 129(18): 4241 - 4248.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V Schaeffer, D Killian, C Desplan, and E. Wimmer
High bicoid levels render the terminal system dispensable for Drosophila head development
Development, January 9, 2000; 127(18): 3993 - 3999.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A Daniel, K Dumstrei, J. Lengyel, and V Hartenstein
The control of cell fate in the embryonic visual system by atonal, tailless and EGFR signaling
Development, January 7, 1999; 126(13): 2945 - 2954.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Eggert, B. Hauck, N. Hildebrandt, W. J. Gehring, and U. Walldorf
Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development
PNAS, March 3, 1998; 95(5): 2343 - 2348.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Schroder, C. Eckert, C. Wolff, and D. Tautz
Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum
PNAS, June 6, 2000; 97(12): 6591 - 6596.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1997