|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 22 4457-4466, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
Y Kishimoto, KH Lee, L Zon, M Hammerschmidt and S Schulte-Merker
MPI fur Entwicklungsbiologie, Tubingen, Germany.
Early dorsoventral pattern formation in vertebrate embryos is regulated by opposing activities of ventralizing bone morphogenetic proteins (BMPs) and dorsal-specific BMP antagonists such as Chordin, Noggin and Follistatin. Specific defects in early dorsoventral patterning have been recently found in a number of zebrafish mutants, which exhibit either a ventralized or dorsalized phenotype. One of these, the ventralized mutant chordino (originally called dino) is caused by a mutation in the zebrafish chordin homologue and interacts genetically with the dorsalized mutant swirl. In swirl mutant embryos, dorsal structures such as notochord and somites are expanded while ventral structures such as blood and nephros are missing. Here we demonstrate that the swirl phenotype is caused by mutations in the zebrafish bmp2 gene (zbmp2). While injection of mRNAs encoded by the mutant alleles has no ventralizing effect, injection of wild-type zbmp2 mRNA leads to a complete rescue of the swirl mutant phenotype. Fertile adult mutant fish were obtained, showing that development after gastrulation is not dependent on zbmp2 function. In addition zBMP2 has no maternal role in mesoderm induction. Our analysis shows that swirl/BMP2, unlike mouse BMP2 but like mouse BMP4, is required for early dorsoventral patterning of the zebrafish embryo.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J.-D. Fauny, B. Thisse, and C. Thisse The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity Development, November 15, 2009; 136(22): 3811 - 3819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tao, Y. Cai, and K. Sampath The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling Development, August 15, 2009; 136(16): 2757 - 2765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Smith, I. C. Joziasse, S. Chocron, M. van Dinther, V. Guryev, M. C. Verhoeven, H. Rehmann, J. J. van der Smagt, P. A. Doevendans, E. Cuppen, et al. Dominant-Negative ALK2 Allele Associates With Congenital Heart Defects Circulation, June 23, 2009; 119(24): 3062 - 3069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Gosse and H. Baier An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina PNAS, February 17, 2009; 106(7): 2236 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Domene, E. Roessler, K. B. El-Jaick, M. Snir, J. L. Brown, J. I. Velez, S. Bale, F. Lacbawan, M. Muenke, and B. Feldman Mutations in the human SIX3 gene in holoprosencephaly are loss of function Hum. Mol. Genet., December 15, 2008; 17(24): 3919 - 3928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Mudumana, D. Hentschel, Y. Liu, A. Vasilyev, and I. A. Drummond odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate Development, October 15, 2008; 135(20): 3355 - 3367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. McReynolds, S. Gupta, M. E. Figueroa, M. C. Mullins, and T. Evans Smad1 and Smad5 differentially regulate embryonic hematopoiesis Blood, December 1, 2007; 110(12): 3881 - 3890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gouttenoire, U. Valcourt, C. Bougault, E. Aubert-Foucher, E. Arnaud, L. Giraud, and F. Mallein-Gerin Knockdown of the Intraflagellar Transport Protein IFT46 Stimulates Selective Gene Expression in Mouse Chondrocytes and Affects Early Development in Zebrafish J. Biol. Chem., October 19, 2007; 282(42): 30960 - 30973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shin, C. H. Shin, J. Tucker, E. A. Ober, F. Rentzsch, K. D. Poss, M. Hammerschmidt, M. C. Mullins, and D. Y. R. Stainier Bmp and Fgf signaling are essential for liver specification in zebrafish Development, June 1, 2007; 134(11): 2041 - 2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Rentzsch, C. Guder, D. Vocke, B. Hobmayer, and T. W. Holstein An ancient chordin-like gene in organizer formation of Hydra PNAS, February 27, 2007; 104(9): 3249 - 3254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Maegawa, M. Varga, and E. S. Weinberg FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer Development, August 15, 2006; 133(16): 3265 - 3276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Szeto and D. Kimelman The regulation of mesodermal progenitor cell commitment to somitogenesis subdivides the zebrafish body musculature into distinct domains Genes & Dev., July 15, 2006; 20(14): 1923 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Reim and M. Brand Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4 Development, July 15, 2006; 133(14): 2757 - 2770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. J. Machingo, A. Fritz, and B. D. Shur A {beta}1,4-galactosyltransferase is required for Bmp2-dependent patterning of the dorsoventral axis during zebrafish embryogenesis Development, June 1, 2006; 133(11): 2233 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gupta, H. Zhu, L. I. Zon, and T. Evans BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis Development, June 1, 2006; 133(11): 2177 - 2187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Poulain, M. Furthauer, B. Thisse, C. Thisse, and T. Lepage Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling Development, June 1, 2006; 133(11): 2189 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Rentzsch, J. Zhang, C. Kramer, W. Sebald, and M. Hammerschmidt Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation Development, March 1, 2006; 133(5): 801 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. J. Pyati, A. E. Webb, and D. Kimelman Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development Development, May 15, 2005; 132(10): 2333 - 2343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Wilm and L. Solnica-Krezel Essential roles of a zebrafish prdm1/blimp1 homolog in embryo patterning and organogenesis Development, January 15, 2005; 132(2): 393 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Little and M. C. Mullins Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning Development, December 1, 2004; 131(23): 5825 - 5835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Martinovic, S. Mazic, V. Kisic, N. Basic, J. Jakic-Razumovic, F. Borovecki, D. Batinic, P. Simic, L. Grgurevic, B. Labar, et al. Expression of Bone Morphogenetic Proteins in Stromal Cells from Human Bone Marrow Long-term Culture J. Histochem. Cytochem., September 1, 2004; 52(9): 1159 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Ramel and A. C. Lekven Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox Development, August 15, 2004; 131(16): 3991 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Szeto and D. Kimelman Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation Development, August 1, 2004; 131(15): 3751 - 3760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Furthauer, J. Van Celst, C. Thisse, and B. Thisse Fgf signalling controls the dorsoventral patterning of the zebrafish embryo Development, June 15, 2004; 131(12): 2853 - 2864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Langenfeld and J. Langenfeld Bone Morphogenetic Protein-2 Stimulates Angiogenesis in Developing Tumors Mol. Cancer Res., March 1, 2004; 2(3): 141 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Marlow,, E. M. Gonzalez,,, C. Yin, C. Rojo, and L. Solnica-Krezel, No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish Development, January 1, 2004; 131(1): 203 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Leung, J. Bischof, I. Soll, D. Niessing, D. Zhang, J. Ma, H. Jackle, and W. Driever bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish Development, August 15, 2003; 130(16): 3639 - 3649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fischer, B. W. Draper, and C. J. Neumann The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation Development, August 1, 2003; 130(15): 3515 - 3524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yabe, T. Shimizu, O. Muraoka, Y.-K. Bae, T. Hirata, H. Nojima, A. Kawakami, T. Hirano, and M. Hibi Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling Development, June 15, 2003; 130(12): 2705 - 2716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sidi, C. Goutel, N. Peyrieras, and F. M. Rosa Maternal induction of ventral fate by zebrafish radar PNAS, March 18, 2003; 100(6): 3315 - 3320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Roman, V. N. Pham, N. D. Lawson, M. Kulik, S. Childs, A. C. Lekven, D. M. Garrity, R. T. Moon, M. C. Fishman, R. J. Lechleider, et al. Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels Development, March 8, 2003; 129(12): 3009 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Walters, G. A. Wayman, J. C. Notis, R. H. Goodman, T. R. Soderling, and J. L. Christian Calmodulin-dependent protein kinase IV mediated antagonism of BMP signaling regulates lineage and survival of hematopoietic progenitors Development, March 5, 2003; 129(6): 1455 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Rusten, R. Cantera, F. C. Kafatos, and R. Barrio The role of TGF{beta} signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates Development, August 1, 2002; 129(15): 3575 - 3584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Thisse and L. I. Zon Organogenesis--Heart and Blood Formation from the Zebrafish Point of View Science, January 18, 2002; 295(5554): 457 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. YELON, J.L. FELDMAN, and B.R. KEEGAN Genetic Regulation of Cardiac Patterning in Zebrafish Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 19 - 26. [Abstract] [PDF]
|
|
|
|
|
|
J. Larrain, M. Oelgeschlager, N. I. Ketpura, B. Reversade, L. Zakin, and E. M. De Robertis Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling Development, November 15, 2001; 128(22): 4439 - 4447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kudoh and I. B. Dawid Role of the iroquois3 homeobox gene in organizer formation PNAS, July 3, 2001; 98(14): 7852 - 7857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Furthauer, F. Reifers, M. Brand, B. Thisse, and C. Thisse sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish Development, June 15, 2001; 128(12): 2175 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Imai, M. A. Gates, A. E. Melby, D. Kimelman, A. F. Schier, and W. S. Talbot The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish Development, June 15, 2001; 128(12): 2407 - 2420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. A. Vitt, S. Y. Hsu, and A. J. W. Hsueh Evolution and Classification of Cystine Knot-Containing Hormones and Related Extracellular Signaling Molecules Mol. Endocrinol., May 1, 2001; 15(5): 681 - 694. [Abstract] [Full Text]
|
|
|
|
|
|
H Bauer, Z Lele, G. Rauch, R Geisler, and M Hammerschmidt The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo Development, January 3, 2001; 128(6): 849 - 858. [Abstract] [PDF]
|
|
|
|
|
|
K. Mintzer, M. Lee, G Runke, J Trout, M Whitman, and M. Mullins Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation Development, January 3, 2001; 128(6): 859 - 869. [Abstract] [PDF]
|
|
|
|
|
|
E. M. Gonzalez, K. Fekany-Lee, A. Carmany-Rampey, C. Erter, J. Topczewski, C. V.E. Wright, and L. Solnica-Krezel Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino Genes & Dev., December 15, 2000; 14(24): 3087 - 3092. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kawahara, T. Wilm, L. Solnica-Krezel, and I. B. Dawid Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation PNAS, October 24, 2000; 97(22): 12121 - 12126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Imai, B. Feldman, A. F. Schier, and W. S. Talbot Analysis of Chromosomal Rearrangements Induced by Postmeiotic Mutagenesis With Ethylnitrosourea in Zebrafish Genetics, May 1, 2000; 155(1): 261 - 272. [Abstract] [Full Text]
|
|
|
|
|
|
P. Blader and U. Strahle Zebrafish developmental genetics and central nervous system development Hum. Mol. Genet., April 1, 2000; 9(6): 945 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Talbot and N. Hopkins Zebrafish mutations and functional analysis of the vertebrate genome Genes & Dev., April 1, 2000; 14(7): 755 - 762. [Full Text]
|
|
|
|
|
|
N. Nakayama, J. Lee, and L. Chiu Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro Blood, April 1, 2000; 95(7): 2275 - 2283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Fekany-Lee, E Gonzalez, V Miller-Bertoglio, and L Solnica-Krezel The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways Development, January 6, 2000; 127(11): 2333 - 2345. [Abstract] [PDF]
|
|
|
|
|
|
D Yelon, B Ticho, M. Halpern, I Ruvinsky, R. Ho, L. Silver, and D. Stainier The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development Development, January 6, 2000; 127(12): 2573 - 2582. [Abstract] [PDF]
|
|
|
|
|
|
H. Sirotkin, S. Dougan, A. Schier, and W. Talbot bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish Development, January 6, 2000; 127(12): 2583 - 2592. [Abstract] [PDF]
|
|
|
|
|
|
B Schmid, M Furthauer, S. Connors, J Trout, B Thisse, C Thisse, and M. Mullins Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation Development, January 3, 2000; 127(5): 957 - 967. [Abstract] [PDF]
|
|
|
|
|
|
V. Nguyen, J Trout, S. Connors, P Andermann, E Weinberg, and M. Mullins Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway Development, January 3, 2000; 127(6): 1209 - 1220. [Abstract] [PDF]
|
|
|
|
|
|
J Larrain, D Bachiller, B Lu, E Agius, S Piccolo, and E. De Robertis BMP-binding modules in chordin: a model for signalling regulation in the extracellular space Development, January 2, 2000; 127(4): 821 - 830. [Abstract] [PDF]
|
|
|
|
|
|
F Reifers, E. Walsh, S Leger, D. Stainier, and M Brand Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar) Development, January 1, 2000; 127(2): 225 - 235. [Abstract] [PDF]
|
|
|
|
|
|
A Dick, M Hild, H Bauer, Y Imai, H Maifeld, A. Schier, W. Talbot, T Bouwmeester, and M Hammerschmidt Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo Development, January 1, 2000; 127(2): 343 - 354. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Bhatia, D. Bonnet, D. Wu, B. Murdoch, J. Wrana, L. Gallacher, and J. E. Dick Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells J. Exp. Med., April 5, 1999; 189(7): 1139 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Gates, L. Kim, E. S. Egan, T. Cardozo, H. I. Sirotkin, S. T. Dougan, D. Lashkari, R. Abagyan, A. F. Schier, and W. S. Talbot A Genetic Linkage Map for Zebrafish: Comparative Analysis and Localization of Genes and Expressed Sequences Genome Res., April 1, 1999; 9(4): 334 - 347. [Abstract] [Full Text]
|
|
|
|
|
|
G Weidinger, U Wolke, M Koprunner, M Klinger, and E Raz Identification of tissues and patterning events required for distinct steps in early migration of zebrafish primordial germ cells Development, January 12, 1999; 126(23): 5295 - 5307. [Abstract] [PDF]
|
|
|
|
|
|
C. Neumann, H Grandel, W Gaffield, S Schulte-Merker, and C Nusslein-Volhard Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity Development, January 11, 1999; 126(21): 4817 - 4826. [Abstract] [PDF]
|
|
|
|
|
|
K. Barth, Y Kishimoto, K. Rohr, C Seydler, S Schulte-Merker, and S. Wilson Bmp activity establishes a gradient of positional information throughout the entire neural plate Development, January 11, 1999; 126(22): 4977 - 4987. [Abstract] [PDF]
|
|
|
|
|
|
S. Connors, J Trout, M Ekker, and M. Mullins The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo Development, January 6, 1999; 126(14): 3119 - 3130. [Abstract] [PDF]
|
|
|
|
|
|
M Hild, A Dick, G. Rauch, A Meier, T Bouwmeester, P Haffter, and M Hammerschmidt The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo Development, January 5, 1999; 126(10): 2149 - 2159. [Abstract] [PDF]
|
|
|
|
|
|
A Meng, B Moore, H Tang, B Yuan, and S Lin A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates Development, January 3, 1999; 126(6): 1259 - 1268. [Abstract] [PDF]
|
|
|
|
|
|
E Pera, S Stein, and M Kessel Ectodermal patterning in the avian embryo: epidermis versus neural plate Development, January 1, 1999; 126(1): 63 - 73. [Abstract] [PDF]
|
|
|
|
|
|
M Nikaido, M Tada, H Takeda, A Kuroiwa, and N Ueno In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning Development, January 1, 1999; 126(1): 181 - 190. [Abstract] [PDF]
|
|
|
|
|
|
Y Grinblat, J Gamse, M Patel, and H Sive Determination of the zebrafish forebrain: induction and patterning Development, January 11, 1998; 125(22): 4403 - 4416. [Abstract] [PDF]
|
|
|
|
|
|
A Streit, K. Lee, I Woo, C Roberts, T. Jessell, and C. Stern Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo Development, January 2, 1998; 125(3): 507 - 519. [Abstract] [PDF]
|
|
|
|
|
|
A. Schuler-Metz, S. Knochel, E. Kaufmann, and W. Knochel The Homeodomain Transcription Factor Xvent-2 Mediates Autocatalytic Regulation of BMP-4 Expression in Xenopus Embryos J. Biol. Chem., October 27, 2000; 275(44): 34365 - 34374. [Abstract] [Full Text] [PDF]
|
|
