|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 22 4707-4716, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
P Wappner, L Gabay and BZ Shilo
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
The formation of the tracheal network in Drosophila is driven by stereotyped migration of cells from the tracheal pits. No cell divisions take place during tracheal migration and the number of cells in each branch is fixed. This work examines the basis for the determination of tracheal branch fates, prior to the onset of migration. We show that the EGF receptor pathway is activated by localized processing of the ligand SPITZ in the tracheal placodes and is responsible for the capacity to form the dorsal trunk and visceral branch. The DPP pathway, on the contrary, is induced in the tracheal pit by local presentation of DPP from the adjacent dorsal and ventral ectodermal cells. This pathway patterns the dorsal and lateral branches. Elimination of both pathways blocks migration of all tracheal branches. Antagonistic interactions between the two pathways are demonstrated. The opposing activities of two pathways may refine the final determination of tracheal branch fates.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Chung and D. J. Andrew The formation of epithelial tubes J. Cell Sci., November 1, 2008; 121(21): 3501 - 3504. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nishimura, Y. Inoue, and S. Hayashi A wave of EGFR signaling determines cell alignment and intercalation in the Drosophila tracheal placode Development, December 1, 2007; 134(23): 4273 - 4282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cela and M. Llimargas Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila Development, August 15, 2006; 133(16): 3115 - 3125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Brodu and J. Casanova The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes & Dev., July 1, 2006; 20(13): 1817 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kato, T. Chihara, and S. Hayashi Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea Development, November 1, 2004; 131(21): 5253 - 5261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dammai, B. Adryan, K. R. Lavenburg, and T. Hsu Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development Genes & Dev., November 15, 2003; 17(22): 2812 - 2824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. del Alamo, J. Terriente, and F. J. Diaz-Benjumea Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs Development, March 6, 2003; 129(8): 1975 - 1982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lavista-Llanos, L. Centanin, M. Irisarri, D. M. Russo, J. M. Gleadle, S. N. Bocca, M. Muzzopappa, P. J. Ratcliffe, and P. Wappner Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar Mol. Cell. Biol., October 1, 2002; 22(19): 6842 - 6853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dorfman, L. Glazer, U. Weihe, M. F. Wernet, and B.-Z. Shilo Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches Development, August 1, 2002; 129(15): 3585 - 3596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sedaghat, W. F. Miranda, and M. J. Sonnenfeld The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea Development, January 6, 2002; 129(11): 2591 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Boube, M. D. Martin-Bermudo, N. H. Brown, and J. Casanova Specific tracheal migration is mediated by complementary expression of cell surface proteins Genes & Dev., June 15, 2001; 15(12): 1554 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Glazer and B. Shilo Hedgehog signaling patterns the tracheal branches Development, January 5, 2001; 128(9): 1599 - 1606. [Abstract] [PDF]
|
|
|
|
|
|
J. Lorenzen, S. Baker, F Denhez, M. Melnick, D. Brower, and L. Perkins Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin Development, January 4, 2001; 128(8): 1403 - 1414. [Abstract] [PDF]
|
|
|
|
|
|
P. Elstob, V Brodu, and A. Gould spalt-dependent switching between two cell fates that are induced by the Drosophila EGF receptor Development, January 3, 2001; 128(5): 723 - 732. [Abstract] [PDF]
|
|
|
|
|
|
K. Yu, S. Srinivasan, O. Shimmi, B. Biehs, K. E. Rashka, D. Kimelman, M. B. O'Connor, and E. Bier Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity Development, May 15, 2000; 127(10): 2143 - 2154. [Abstract] [PDF]
|
|
|
|
|
|
M Llimargas Wingless and its signalling pathway have common and separable functions during tracheal development Development, January 10, 2000; 127(20): 4407 - 4417. [Abstract] [PDF]
|
|
|
|
|
|
T Chihara and S Hayashi Control of tracheal tubulogenesis by Wingless signaling Development, January 10, 2000; 127(20): 4433 - 4442. [Abstract] [PDF]
|
|
|
|
|
|
G. Beitel and M. Krasnow Genetic control of epithelial tube size in the Drosophila tracheal system Development, January 8, 2000; 127(15): 3271 - 3282. [Abstract] [PDF]
|
|
|
|
|
|
M. Myat and D. Andrew Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia Development, January 2, 2000; 127(4): 679 - 691. [Abstract] [PDF]
|
|
|
|
|
|
L. Dobens, J. Peterson, J Treisman, and L. Raftery Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary Development, January 2, 2000; 127(4): 745 - 754. [Abstract] [PDF]
|
|
|
|
 |
|
 R. J. Metzger and M. A. Krasnow Genetic Control of Branching Morphogenesis Science, June 4, 1999; 284(5420): 1635 - 1639. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. R. Breen Mutant Alleles of the Drosophila trithorax Gene Produce Common and Unusual Homeotic and Other Developmental Phenotypes Genetics, May 1, 1999; 152(1): 319 - 344. [Abstract] [Full Text]
|
|
|
|
|
|
A Jazwinska, C Rushlow, and S Roth The role of brinker in mediating the graded response to Dpp in early Drosophila embryos Development, January 8, 1999; 126(15): 3323 - 3334. [Abstract] [PDF]
|
|
|
|
|
|
A Kopp, R. Blackman, and I Duncan Wingless, decapentaplegic and EGF receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila Development, January 8, 1999; 126(16): 3495 - 3507. [Abstract] [PDF]
|
|
|
|
|
|
A Amin, Y Li, and R Finkelstein Hedgehog activates the EGF receptor pathway during Drosophila head development Development, January 6, 1999; 126(12): 2623 - 2630. [Abstract] [PDF]
|
|
|
|
|
|
A Guichard, B Biehs, M. Sturtevant, L Wickline, J Chacko, K Howard, and E Bier rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development Development, January 6, 1999; 126(12): 2663 - 2676. [Abstract] [PDF]
|
|
|
|
|
|
D. Montell The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development Development, January 6, 1999; 126(14): 3035 - 3046. [Abstract] [PDF]
|
|
|
|
|
|
R Nagaraj, A. Pickup, R Howes, K Moses, M Freeman, and U Banerjee Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial Development, January 2, 1999; 126(5): 975 - 985. [Abstract] [PDF]
|
|
|
|
|
|
J. Wiesen, P Young, Z Werb, and G. Cunha Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development Development, January 1, 1999; 126(2): 335 - 344. [Abstract] [PDF]
|
|
|
|
|
|
D. Szüts, S. Eresh, and M. Bienz Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction Genes & Dev., July 1, 1998; 12(13): 2022 - 2035. [Abstract] [Full Text]
|
|
|
|
|
|
C. Chen, R. Kuhnlein, K. Eulenberg, S Vincent, M Affolter, and R Schuh The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development Development, January 12, 1998; 125(24): 4959 - 4968. [Abstract] [PDF]
|
|
|
|
|
|
A. Michelson, S Gisselbrecht, E Buff, and J. Skeath Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila Development, January 11, 1998; 125(22): 4379 - 4389. [Abstract] [PDF]
|
|
