|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 23 4729-4738, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
B Kablar, K Krastel, C Ying, A Asakura, SJ Tapscott and MA Rudnicki
Institute for Molecular Biology and Biotechnology, Cancer Research Group, McMaster University, Hamilton, Ontario, Canada.
The myogenic progenitors of epaxial (paraspinal and intercostal) and hypaxial (limb and abdominal wall) musculature are believed to originate in dorsal-medial and ventral-lateral domains, respectively, of the developing somite. To investigate the hypothesis that Myf-5 and MyoD have different roles in the development of epaxial and hypaxial musculature, we further characterized myogenesis in Myf-5- and MyoD-deficient embryos by several approaches. We examined expression of a MyoD-lacZ transgene in Myf-5 and MyoD mutant embryos to characterize the temporal-spatial patterns of myogenesis in mutant embryos. In addition, we performed immunohistochemistry on sectioned Myf-5 and MyoD mutant embryos with antibodies reactive with desmin, nestin, myosin heavy chain, sarcomeric actin, Myf-5, MyoD and myogenin. While MyoD(-/-) embryos displayed normal development of paraspinal and intercostal muscles in the body proper, muscle development in limb buds and brachial arches was delayed by about 2.5 days. By contrast, Myf-5(-/-) embryos displayed normal muscle development in limb buds and brachial arches, and markedly delayed development of paraspinal and intercostal muscles. Although MyoD mutant embryos exhibited delayed development of limb musculature, normal migration of Pax-3-expressing cells into the limb buds and normal subsequent induction of Myf-5 in myogenic precursors was observed. These results suggest that Myf-5 expression in the limb is insufficient for the normal progression of myogenic development. Taken together, these observations strongly support the hypothesis that Myf-5 and MyoD play unique roles in the development of epaxial and hypaxial muscle, respectively.
This article has been cited by other articles:
|
|
 |
|
  J. Hewitt, X. Lu, L. Gilbert, and M. S. Nanes The Muscle Transcription Factor MyoD Promotes Osteoblast Differentiation by Stimulation of the Osterix Promoter Endocrinology, July 1, 2008; 149(7): 3698 - 3707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gensch, T. Borchardt, A. Schneider, D. Riethmacher, and T. Braun Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis Development, May 1, 2008; 135(9): 1597 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Grenier, A. Scime, F. Le Grand, A. Asakura, C. Perez-Iratxeta, M. A. Andrade-Navarro, P. A. Labosky, and M. A. Rudnicki Resident Endothelial Precursors in Muscle, Adipose, and Dermis Contribute to Postnatal Vasculogenesis Stem Cells, December 1, 2007; 25(12): 3101 - 3110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Maves, A. J. Waskiewicz, B. Paul, Y. Cao, A. Tyler, C. B. Moens, and S. J. Tapscott Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation Development, September 15, 2007; 134(18): 3371 - 3382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Giordani, L. Bajard, J. Demignon, P. Daubas, M. Buckingham, and P. Maire Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs PNAS, July 3, 2007; 104(27): 11310 - 11315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Barbaric, G. Miller, and T. N. Dear Appearances can be deceiving: phenotypes of knockout mice Brief Funct Genomic Proteomic, June 20, 2007; (2007) elm008v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schuster-Gossler, R. Cordes, and A. Gossler Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants PNAS, January 9, 2007; 104(2): 537 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Baugh and C. P. Hunter MyoD, modularity, and myogenesis: conservation of regulators and redundancy in C. elegans Genes & Dev., December 15, 2006; 20(24): 3342 - 3346. [Full Text] [PDF]
|
|
|
|
|
|
E. Hill, T. Boontheekul, and D. J. Mooney Tissue Engineering Special Feature: Regulating activation of transplanted cells controls tissue regeneration PNAS, February 21, 2006; 103(8): 2494 - 2499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Krauss, F. Cole, U. Gaio, G. Takaesu, W. Zhang, and J.-S. Kang Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact J. Cell Sci., June 1, 2005; 118(11): 2355 - 2362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Brent, T. Braun, and C. J. Tabin Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development Development, February 1, 2005; 132(3): 515 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Lee, W. Goring, M. Ochs, C. Muhlfeld, G. Steding, I. Paprotta, W. Engel, and I. M. Adham Sox15 Is Required for Skeletal Muscle Regeneration Mol. Cell. Biol., October 1, 2004; 24(19): 8428 - 8436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Delfini and D. Duprez Ectopic Myf5 or MyoD prevents the neuronal differentiation program in addition to inducing skeletal muscle differentiation, in the chick neural tube Development, February 15, 2004; 131(4): 713 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-Z. Wang, C. H. Washabaugh, Y. Yao, J.-M. Wang, L. Zhang, M. P. Ontell, S. C. Watkins, M. A. Rudnicki, and M. Ontell Aberrant Development of Motor Axons and Neuromuscular Synapses in MyoD-Null Mice J. Neurosci., June 15, 2003; 23(12): 5161 - 5169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Laclef, G. Hamard, J. Demignon, E. Souil, C. Houbron, and P. Maire Altered myogenesis in Six1-deficient mice Development, May 15, 2003; 130(10): 2239 - 2252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L'honore, N. J. Lamb, M. Vandromme, P. Turowski, G. Carnac, and A. Fernandez MyoD Distal Regulatory Region Contains an SRF Binding CArG Element Required for MyoD Expression in Skeletal Myoblasts and during Muscle Regeneration Mol. Biol. Cell, May 1, 2003; 14(5): 2151 - 2162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Teboul, J. Hadchouel, P. Daubas, D. Summerbell, M. Buckingham, and P. W. J. Rigby The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis Development, January 10, 2002; 129(19): 4571 - 4580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Lindsay and A. Baldini Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region Hum. Mol. Genet., April 1, 2001; 10(9): 997 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ordahl, E Berdougo, S. Venters, and W. Denetclaw The dermomyotome dorsomedial lip drives growth and morphogenesis of both the primary myotome and dermomyotome epithelium Development, January 5, 2001; 128(10): 1731 - 1744. [Abstract] [PDF]
|
|
|
|
|
|
J. Carvajal, D Cox, D Summerbell, and P. Rigby A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development Development, January 5, 2001; 128(10): 1857 - 1868. [Abstract] [PDF]
|
|
|
|
|
|
E Hirsinger, P Malapert, J Dubrulle, M. Delfini, D Duprez, D Henrique, D Ish-Horowicz, and O Pourquie Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation Development, January 1, 2001; 128(1): 107 - 116. [Abstract] [PDF]
|
|
|
|
 |
|
 J. D. White, A. Scaffidi, M. Davies, J. McGeachie, M. A. Rudnicki, and M. D. Grounds Myotube Formation is Delayed but not Prevented in MyoD-deficient Skeletal Muscle: Studies in Regenerating Whole Muscle Grafts of Adult Mice J. Histochem. Cytochem., November 1, 2000; 48(11): 1531 - 1544. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. C. LEKVEN, K. A. HELDE, C. J. THORPE, R. ROOKE, and R. T. MOON Reverse genetics in zebrafish Physiol Genomics, March 14, 2000; 2(2): 37 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tallquist, K. Weismann, M Hellstrom, and P Soriano Early myotome specification regulates PDGFA expression and axial skeleton development Development, January 12, 2000; 127(23): 5059 - 5070. [Abstract] [PDF]
|
|
|
|
|
|
M Delfini, E Hirsinger, O Pourquie, and D Duprez Delta 1-activated notch inhibits muscle differentiation without affecting Myf5 and Pax3 expression in chick limb myogenesis Development, January 12, 2000; 127(23): 5213 - 5224. [Abstract] [PDF]
|
|
|
|
|
|
D Summerbell, P. Ashby, O Coutelle, D Cox, S Yee, and P. Rigby The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors Development, January 9, 2000; 127(17): 3745 - 3757. [Abstract] [PDF]
|
|
|
|
|
|
B Kablar, S Tajbakhsh, and M. Rudnicki Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent Development, January 4, 2000; 127(8): 1627 - 1639. [Abstract] [PDF]
|
|
|
|
 |
|
 L. A. Sabourin, A. Girgis-Gabardo, P. Seale, A. Asakura, and M. A. Rudnicki Reduced Differentiation Potential of Primary MyoD-/- Myogenic Cells Derived from Adult Skeletal Muscle J. Cell Biol., February 22, 1999; 144(4): 631 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Wilson-Rawls, C. Hurt, S. Parsons, and A Rawls Differential regulation of epaxial and hypaxial muscle development by paraxis Development, January 12, 1999; 126(23): 5217 - 5229. [Abstract] [PDF]
|
|
|
|
|
|
Y Cinnamon, N Kahane, and C Kalcheim Characterization of the early development of specific hypaxial muscles from the ventrolateral myotome Development, January 10, 1999; 126(19): 4305 - 4315. [Abstract] [PDF]
|
|
|
|
|
|
K. Kucharczuk, C. Love, N. Dougherty, and D. Goldhamer Fine-scale transgenic mapping of the MyoD core enhancer: MyoD is regulated by distinct but overlapping mechanisms in myotomal and non-myotomal muscle lineages Development, January 5, 1999; 126(9): 1957 - 1965. [Abstract] [PDF]
|
|
|
|
|
|
J. E. LeCouter, B. Kablar, W. R. Hardy, C. Ying, L. A. Megeney, L. L. May, and M. A. Rudnicki Strain-Dependent Myeloid Hyperplasia, Growth Deficiency, and Accelerated Cell Cycle in Mice Lacking the Rb-Related p107 Gene Mol. Cell. Biol., December 1, 1998; 18(12): 7455 - 7465. [Abstract] [Full Text]
|
|
|
|
|
|
J. LeCouter, B Kablar, P. Whyte, C Ying, and M. Rudnicki Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene Development, January 12, 1998; 125(23): 4669 - 4679. [Abstract] [PDF]
|
|
|
|
|
|
S Tajbakhsh, U Borello, E Vivarelli, R Kelly, J Papkoff, D Duprez, M Buckingham, and G Cossu Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5 Development, January 11, 1998; 125(21): 4155 - 4162. [Abstract] [PDF]
|
|
|
|
|
|
N Kato and H Aoyama Dermomyotomal origin of the ribs as revealed by extirpation and transplantation experiments in chick and quail embryos Development, January 9, 1998; 125(17): 3437 - 3443. [Abstract] [PDF]
|
|
|
|
|
|
S Dietrich, F. Schubert, C Healy, P. Sharpe, and A Lumsden Specification of the hypaxial musculature Development, January 6, 1998; 125(12): 2235 - 2249. [Abstract] [PDF]
|
|
