|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 23 4819-4826, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
NM Bonini, QT Bui, GL Gray-Board and JM Warrick
Department of Biology, University of Pennsylvania, Philadelphia 19104-6018, USA. nbonini@sas.upenn.edu
The fly eyes absent (eya) gene which is essential for compound eye development in Drosophila, was shown to be functionally replaceable in eye development by a vertebrate Eya homolog. The relationship between eya and that of the eyeless gene, a Pax-6 homolog, critical for eye formation in both flies and man, was defined: eya was found to be essential for eye formation by eyeless. Moreover, eya could itself direct ectopic eye formation, indicating that eya has the capacity to function as a master control gene for eye formation. Finally, we show that eya and eyeless together were more effective in eye formation than either gene alone. These data indicate conservation of the pathway of eya function between flies and vertebrates; they suggest a model whereby eya/Eya gene function is essential for eye formation by eyeless/Pax-6, and that eya/Eya can in turn mediate, via a regulatory loop, the activity of eyeless/Pax-6 in eye formation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. N. Patrick, B. J. Schiemann, K. Yang, R. Zhao, and H. L. Ford Biochemical and Functional Characterization of Six SIX1 Branchio-oto-renal Syndrome Mutations J. Biol. Chem., July 31, 2009; 284(31): 20781 - 20790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Lindsay, R. Baines, R. ffrench-Constant, K. Lilley, H. T. Jacobs, and K. M. C. O'Dell The Dominant Cold-Sensitive Out-Cold Mutants of Drosophila melanogaster Have Novel Missense Mutations in the Voltage-Gated Sodium Channel Gene paralytic Genetics, October 1, 2008; 180(2): 873 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Braid and E. M. Verheyen Drosophila Nemo Promotes Eye Specification Directed by the Retinal Determination Gene Network Genetics, September 1, 2008; 180(1): 283 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Clements, Z. Lu, W. J. Gehring, I. A. Meinertzhagen, and P. Callaerts Central projections of photoreceptor axons originating from ectopic eyes in Drosophila PNAS, July 1, 2008; 105(26): 8968 - 8973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Schlosser How old genes make a new head: redeployment of Six and Eya genes during the evolution of vertebrate cranial placodes Integr. Comp. Biol., September 1, 2007; 47(3): 343 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Zhang, S. Ranade, C. Q. Cai, C. Clouser, and F. Pignoni Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So Development, December 15, 2006; 133(24): 4881 - 4889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Venkei, I. Gaspar, G. Toth, and J. Szabad {alpha}4-Tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during earlyx Drosophila embryogenesis J. Cell Sci., August 1, 2006; 119(15): 3238 - 3248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Berger, J. E. Davies, S. Luo, M. Y. Pasco, I. Majoul, C. J. O'Kane, and D. C. Rubinsztein Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion Hum. Mol. Genet., February 1, 2006; 15(3): 453 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Katsuyama, T. Sugawara, M. Tatsumi, Y. Oshima, W. J. Gehring, T. Aigaki, and S. Kurata Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification PNAS, November 1, 2005; 102(44): 15918 - 15923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Berger, E. K. Ttofi, C. H. Michel, M. Y. Pasco, S. Tenant, D. C. Rubinsztein, and C. J. O'Kane Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway Hum. Mol. Genet., October 15, 2005; 14(20): 3003 - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pauli, M. Seimiya, J. Blanco, and W. J. Gehring Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog Development, June 15, 2005; 132(12): 2771 - 2782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mutsuddi, B. Chaffee, J. Cassidy, S. J. Silver, T. L. Tootle, and I. Rebay Using Drosophila to Decipher How Mutations Associated With Human Branchio-Oto-Renal Syndrome and Optical Defects Compromise the Protein Tyrosine Phosphatase and Transcriptional Functions of Eyes Absent Genetics, June 1, 2005; 170(2): 687 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Azuma, K. Tadokoro, A. Asaka, M. Yamada, Y. Yamaguchi, H. Handa, S. Matsushima, T. Watanabe, Y. Kida, T. Ogura, et al. Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor Hum. Mol. Genet., April 15, 2005; 14(8): 1059 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kutejova, B. Engist, M. Mallo, B. Kanzler, and N. Bobola Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme Development, February 1, 2005; 132(3): 469 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Silver and I. Rebay Signaling circuitries in development: insights from the retinal determination gene network Development, January 1, 2005; 132(1): 3 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Embry, J. L. Glick, M. E. Linder, and P. J. Casey Reciprocal Signaling between the Transcriptional Co-Factor Eya2 and Specific Members of the G{alpha}i Family Mol. Pharmacol., November 1, 2004; 66(5): 1325 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. D'Avino, M. S. Savoian, and D. M. Glover Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac J. Cell Biol., July 5, 2004; 166(1): 61 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Inlow and L. L. Restifo Molecular and Comparative Genetics of Mental Retardation Genetics, February 1, 2004; 166(2): 835 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thomas and P. W. Ingham Hedgehog Signaling in the Drosophila Eye and Head: An Analysis of the Effects of Different patched Trans-heterozygotes Genetics, December 1, 2003; 165(4): 1915 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Silver, E. L. Davies, L. Doyon, and I. Rebay Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network Mol. Cell. Biol., September 1, 2003; 23(17): 5989 - 5999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. T. DOW and S. A. DAVIES Integrative Physiology and Functional Genomics of Epithelial Function in a Genetic Model Organism Physiol Rev, July 1, 2003; 83(3): 687 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Jang, J.-L. Chao, N. Jones, L.-C. Yao, D. A. Bessarab, Y. M. Kuo, S. Jun, C. Desplan, S. K. Beckendorf, and Y. H. Sun Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development Development, July 1, 2003; 130(13): 2939 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Pappu, R. Chen, B. W. Middlebrooks, C. Woo, U. Heberlein, and G. Mardon Mechanism of hedgehog signaling during Drosophila eye development Development, July 1, 2003; 130(13): 3053 - 3062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Cadigan, A. D. Jou, and R. Nusse Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless Development, March 9, 2003; 129(14): 3393 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bessa, B. Gebelein, F. Pichaud, F. Casares, and R. S. Mann Combinatorial control of Drosophila eye development by Eyeless, Homothorax, and Teashirt Genes & Dev., September 15, 2002; 16(18): 2415 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Clark, B. E. Fee, and J. L. Cleveland Misexpression of the Eyes Absent Family Triggers the Apoptotic Program J. Biol. Chem., January 25, 2002; 277(5): 3560 - 3567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Punzo, M. Seimiya, S. Flister, W. J. Gehring, and S. Plaza Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer Development, January 2, 2002; 129(3): 625 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bernier, W. Vukovich, L. Neidhardt, B. G. Herrmann, and P. Gruss Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium Development, October 15, 2001; 128(20): 3987 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Punzo, S. Kurata, and W. J. Gehring The eyeless homeodomain is dispensable for eye development in Drosophila Genes & Dev., July 1, 2001; 15(13): 1716 - 1723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Davis, W. Shen, Y. I. Sandler, M. Amoui, P. Purcell, R. Maas, C.-N. Ou, H. Vogel, A. L. Beaudet, and G. Mardon Dach1 Mutant Mice Bear No Gross Abnormalities in Eye, Limb, and Brain Development and Exhibit Postnatal Lethality Mol. Cell. Biol., March 1, 2001; 21(5): 1484 - 1490. [Abstract] [Full Text]
|
|
|
|
|
|
S. Wayne, N. G. Robertson, F. DeClau, N. Chen, K. Verhoeven, S. Prasad, L. Tranebjarg, C. C. Morton, A. F. Ryan, G. Van Camp, et al. Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus Hum. Mol. Genet., February 1, 2001; 10(3): 195 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Treisman Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development Development, January 2, 2001; 128(4): 603 - 615. [Abstract] [PDF]
|
|
|
|
 |
|
 S. RICKARD, M. BOXER, R. TROMPETER, and M. BITNER-GLINDZICZ Importance of clinical evaluation and molecular testing in the branchio-oto-renal (BOR) syndrome and overlapping phenotypes J. Med. Genet., August 1, 2000; 37(8): 623 - 627. [Full Text]
|
|
|
|
|
|
Q. T. Bui, J. E. Zimmerman, H. Liu, and N. M. Bonini Molecular Analysis of Drosophila eyes absent Mutants Reveals Features of the Conserved Eya Domain Genetics, June 1, 2000; 155(2): 709 - 720. [Abstract] [Full Text]
|
|
|
|
|
|
N. Azuma, A. Hirakiyama, T. Inoue, A. Asaka, and M. Yamada Mutations of a human homologue of the Drosophila eyes absent gene (EYA1) detected in patients with congenital cataracts and ocular anterior segment anomalies Hum. Mol. Genet., February 12, 2000; 9(3): 363 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rebay, F. Chen, F. Hsiao, P. A. Kolodziej, B. H. Kuang, T. Laverty, C. Suh, M. Voas, A. Williams, and G. M. Rubin A Genetic Screen for Novel Components of the Ras/Mitogen-Activated Protein Kinase Signaling Pathway That Interact With the yan Gene of Drosophila Identifies split ends, a New RNA Recognition Motif-Containing Protein Genetics, February 1, 2000; 154(2): 695 - 712. [Abstract] [Full Text]
|
|
|
|
|
|
A Noveen, A Daniel, and V Hartenstein Early development of the Drosophila mushroom body: the roles of eyeless and dachshund Development, January 8, 2000; 127(16): 3475 - 3488. [Abstract] [PDF]
|
|
|
|
|
|
S. Martini, G Roman, S Meuser, G Mardon, and R. Davis The retinal determination gene, dachshund, is required for mushroom body cell differentiation Development, January 6, 2000; 127(12): 2663 - 2672. [Abstract] [PDF]
|
|
|
|
|
|
M Seimiya and W. Gehring The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism Development, January 5, 2000; 127(9): 1879 - 1886. [Abstract] [PDF]
|
|
|
|
|
|
J Curtiss and M Mlodzik Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent Development, January 3, 2000; 127(6): 1325 - 1336. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Zimmerman, Q. T. Bui, H. Liu, and N. M. Bonini Molecular Genetic Analysis of Drosophila eyes absent Mutants Reveals an Eye Enhancer Element Genetics, January 1, 2000; 154(1): 237 - 246. [Abstract] [Full Text]
|
|
|
|
|
|
T. A. Heanue, R. Reshef, R. J. Davis, G. Mardon, G. Oliver, S. Tomarev, A. B. Lassar, and C. J. Tabin Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation Genes & Dev., December 15, 1999; 13(24): 3231 - 3243. [Abstract] [Full Text]
|
|
|
|
|
|
H. Ohto, S. Kamada, K. Tago, S.-I. Tominaga, H. Ozaki, S. Sato, and K. Kawakami Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya Mol. Cell. Biol., October 1, 1999; 19(10): 6815 - 6824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hauck, W. J. Gehring, and U. Walldorf Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila PNAS, January 19, 1999; 96(2): 564 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Niimi, M Seimiya, U Kloter, S Flister, and W. Gehring Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila Development, January 5, 1999; 126(10): 2253 - 2260. [Abstract] [PDF]
|
|
|
|
|
|
R Chen, G Halder, Z Zhang, and G Mardon Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila Development, January 2, 1999; 126(5): 935 - 943. [Abstract] [PDF]
|
|
|
|
|
|
D. Pan and G. M. Rubin Targeted expression of teashirt induces ectopic eyes in Drosophila PNAS, December 22, 1998; 95(26): 15508 - 15512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Eggert, B. Hauck, N. Hildebrandt, W. J. Gehring, and U. Walldorf Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development PNAS, March 3, 1998; 95(5): 2343 - 2348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kumar, M Tio, F Hsiung, S Akopyan, L Gabay, R Seger, B. Shilo, and K Moses Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation Development, January 10, 1998; 125(19): 3875 - 3885. [Abstract] [PDF]
|
|
|
|
|
|
D. Hazelett, M Bourouis, U Walldorf, and J. Treisman decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc Development, January 9, 1998; 125(18): 3741 - 3751. [Abstract] [PDF]
|
|
|
|
|
|
T Hollemann, E Bellefroid, and T Pieler The Xenopus homologue of the Drosophila gene tailless has a function in early eye development Development, January 7, 1998; 125(13): 2425 - 2432. [Abstract] [PDF]
|
|
|
|
|
|
G Halder, P Callaerts, S Flister, U Walldorf, U Kloter, and W. Gehring Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development Development, January 6, 1998; 125(12): 2181 - 2191. [Abstract] [PDF]
|
|
|
|
|
|
A. G. Ridgeway and I. S. Skerjanc Pax3 Is Essential for Skeletal Myogenesis and the Expression of Six1 and Eya2 J. Biol. Chem., May 25, 2001; 276(22): 19033 - 19039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Onuma, S. Takahashi, M. Asashima, S. Kurata, and W. J. Gehring Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies PNAS, February 19, 2002; 99(4): 2020 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kurata, M. J. Go, S. Artavanis-Tsakonas, and W. J. Gehring Notch signaling and the determination of appendage identity PNAS, February 29, 2000; 97(5): 2117 - 2122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kurusu, T. Nagao, U. Walldorf, S. Flister, W. J. Gehring, and K. Furukubo-Tokunaga Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and dachshund genes PNAS, February 29, 2000; 97(5): 2140 - 2144. [Abstract] [Full Text] [PDF]
|
|
