|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 24 4917-4926, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
M Grammont, B Dastugue and JL Couderc
Institut National de la Sante et de la Recherche Medicale U384, Laboratoire de Biochimie, UFR Medecine, Clermont-Ferrand, France.
We have characterized a new gene, called toucan, that is expressed and required in germline cells to promote proper differentiation of the somatic follicle cells. toucan mutant ovaries are defective in (i) the enclosure of newly formed germline cysts by the follicle cells, (ii) the formation of interfollicular stalks, (iii) the migration of the follicle cells over the oocyte and (iv) the formation of the eggshell. Overexpression of a toucan cDNA in the germline leads to the production of longer interfollicular stalks than wild-type ovaries, a phenotype that is the exact opposite of the toucan mutant phenotype. This observation shows that the formation of the interfollicular stalks depends not only on interactions among the somatic cells but also requires a germline signal. Moreover, dominant interactions have been observed between toucan and certain alleles of the daughterless, Notch and Delta genes, each of which is required in the somatic cells for the formation of egg chambers. toucan encodes for a large protein with a coiled-coil domain but has no other homology with known proteins. We propose that toucan participates in the production or localization of a germline-specific signal(s) that is required for the patterning of the follicular epithelium.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. M. O'Reilly, A. C. Ballew, B. Miyazawa, H. Stocker, E. Hafen, and M. A. Simon Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells Development, July 15, 2006; 133(14): 2627 - 2638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Mirouse, B. Dastugue, and J.-L. Couderc The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability Genes Cells, January 1, 2005; 10(1): 37 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Besse, D. Busson, and A.-M. Pret Fused-dependent Hedgehog signal transduction is required for somatic cell differentiation during Drosophila egg chamber formation Development, September 1, 2002; 129(17): 4111 - 4124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Smith III and C. Cronmiller The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation Development, December 1, 2001; 128(23): 4705 - 4714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grammont and K. D. Irvine fringe and Notch specify polar cell fate during Drosophila oogenesis Development, June 15, 2001; 128(12): 2243 - 2253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Jackson and C. A. Berg Soma-to-Germline Interactions During Drosophila Oogenesis Are Influenced by Dose-Sensitive Interactions Between cut and the Genes cappuccino, ovarian tumor and agnostic Genetics, September 1, 1999; 153(1): 289 - 303. [Abstract] [Full Text]
|
|
|
|
|
|
M. Tworoger, M. K. Larkin, Z. Bryant, and H. Ruohola-Baker Mosaic Analysis in the Drosophila Ovary Reveals a Common Hedgehog-Inducible Precursor Stage for Stalk and Polar Cells Genetics, February 1, 1999; 151(2): 739 - 748. [Abstract] [Full Text]
|
|
