|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 3 603-615, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
H Li, C Tierney, L Wen, JY Wu and Y Rao
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Two bilaterally symmetric eyes arise from the anterior neural plate in vertebrate embryos. An interesting question is whether both eyes share a common developmental origin or they originate separately. We report here that the expression pattern of a new gene ET reveals that there is a single retina field which resolves into two separate primordia, a suggestion supported by the expression pattern of the Xenopus Pax-6 gene. Lineage tracing experiments demonstrate that retina field resolution is not due to migration of cells in the median region to the lateral parts of the field. Removal of the prechordal mesoderm led to formation of a single retina both in chick embryos and in Xenopus explants. Transplantation experiments in chick embryos indicate that the prechordal plate is able to suppress Pax-6 expression. Our results provide direct evidence for the existence of a single retina field, indicate that the retina field is resolved by suppression of retina formation in the median region of the field, and demonstrate that the prechordal plate plays a primary signaling role in retina field resolution.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. S. Meyer, R. L. Shearer, E. E. Capowski, L. S. Wright, K. A. Wallace, E. L. McMillan, S.-C. Zhang, and D. M. Gamm From the Cover: Modeling early retinal development with human embryonic and induced pluripotent stem cells PNAS, September 29, 2009; 106(39): 16698 - 16703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kot-Leibovich and A. Fainsod Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation Dis. Model. Mech., May 1, 2009; 2(5-6): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nakaya, H.-S. Lee, Y. Takada, I. Tzchori, and S. I. Tomarev Zebrafish Olfactomedin 1 Regulates Retinal Axon Elongation In Vivo and Is a Modulator of Wnt Signaling Pathway J. Neurosci., July 30, 2008; 28(31): 7900 - 7910. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. England, G. B. Blanchard, L. Mahadevan, and R. J. Adams A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia Development, December 1, 2006; 133(23): 4613 - 4617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Pan, S. Nekkalapudi, L. E. Kelly, and H. M. El-Hodiri The Rx-like Homeobox Gene (Rx-L) Is Necessary for Normal Photoreceptor Development. Invest. Ophthalmol. Vis. Sci., October 1, 2006; 47(10): 4245 - 4253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirose, Z. M. Varga, H. Kondoh, and M. Furutani-Seiki Single cell lineage and regionalization of cell populations during Medaka neurulation Development, June 1, 2004; 131(11): 2553 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris Specification of the vertebrate eye by a network of eye field transcription factors Development, November 1, 2003; 130(21): 5155 - 5167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Galli, A. Roure, R. Zeller, and R. Dono Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos Development, October 15, 2003; 130(20): 4919 - 4929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. B. Samat and L. Flores-Samat Neuropathologic Research Strategies in Holoprosencephaly J Child Neurol, December 1, 2001; 16(12): 918 - 931. [Abstract] [PDF]
|
|
|
|
|
|
O Kazanskaya, A Glinka, and C Niehrs The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning Development, January 11, 2000; 127(22): 4981 - 4992. [Abstract] [PDF]
|
|
|
|
|
|
S Winkler, F Loosli, T Henrich, Y Wakamatsu, and J Wittbrodt The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye Development, January 5, 2000; 127(9): 1911 - 1919. [Abstract] [PDF]
|
|
|
|
|
|
M.-l. He, L. Wen, C. E. Campbell, J. Y. Wu, and Y. Rao Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome PNAS, August 31, 1999; 96(18): 10212 - 10217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Humbert-Lan and T. Pieler Regulation of DNA Binding Activity and Nuclear Transport of B-Myb in Xenopus Oocytes J. Biol. Chem., April 9, 1999; 274(15): 10293 - 10300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Szeto, C. Rodriguez-Esteban, A. K. Ryan, S. M. O'Connell, F. Liu, C. Kioussi, A. S. Gleiberman, J. C. Izpisúa-Belmonte, and M. G. Rosenfeld Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development Genes & Dev., February 15, 1999; 13(4): 484 - 494. [Abstract] [Full Text]
|
|
|
|
|
|
Z. Varga, J Wegner, and M Westerfield Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops Development, January 12, 1999; 126(24): 5533 - 5546. [Abstract] [PDF]
|
|
|
|
|
|
R. Chow, C. Altmann, R. Lang, and A Hemmati-Brivanlou Pax6 induces ectopic eyes in a vertebrate Development, January 10, 1999; 126(19): 4213 - 4222. [Abstract] [PDF]
|
|
|
|
|
|
G. Ermakova, E. Alexandrova, O. Kazanskaya, O. Vasiliev, M. Smith, and A. Zaraisky The homeobox gene, Xanf-1, can control both neural differentiation and patterning in the presumptive anterior neurectoderm of the Xenopus laevis embryo Development, January 10, 1999; 126(20): 4513 - 4523. [Abstract] [PDF]
|
|
|
|
|
|
M Andreazzoli, G Gestri, D Angeloni, E Menna, and G Barsacchi Role of Xrx1 in Xenopus eye and anterior brain development Development, January 6, 1999; 126(11): 2451 - 2460. [Abstract] [PDF]
|
|
|
|
|
|
T Dheen, I Sleptsova-Friedrich, Y Xu, M Clark, H Lehrach, Z Gong, and V Korzh Zebrafish tbx-c functions during formation of midline structures Development, January 6, 1999; 126(12): 2703 - 2713. [Abstract] [PDF]
|
|
|
|
|
|
M. Horb and G. Thomsen Tbx5 is essential for heart development Development, January 4, 1999; 126(8): 1739 - 1751. [Abstract] [PDF]
|
|
|
|
|
|
H Knoetgen, C Viebahn, and M Kessel Head induction in the chick by primitive endoderm of mammalian, but not avian origin Development, January 2, 1999; 126(4): 815 - 825. [Abstract] [PDF]
|
|
|
|
|
|
J. Toy, J.-M. Yang, G. S. Leppert, and O. H. Sundin The Optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes PNAS, September 1, 1998; 95(18): 10643 - 10648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kohtz, D. Baker, G Corte, and G Fishell Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog Development, January 12, 1998; 125(24): 5079 - 5089. [Abstract] [PDF]
|
|
|
|
|
|
S Glardon, L. Holland, W. Gehring, and N. Holland Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution Development, January 7, 1998; 125(14): 2701 - 2710. [Abstract] [PDF]
|
|
|
|
|
|
G Halder, P Callaerts, S Flister, U Walldorf, U Kloter, and W. Gehring Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development Development, January 6, 1998; 125(12): 2181 - 2191. [Abstract] [PDF]
|
|
|
|
 |
|
 K.M. Weiss, D.W. Stock, and Z. Zhao Dynamic Interactions and the Evolutionary Genetics of Dental Patterning Critical Reviews in Oral Biology & Medicine, January 1, 1998; 9(4): 369 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Pera and M Kessel Patterning of the chick forebrain anlage by the prechordal plate Development, January 10, 1997; 124(20): 4153 - 4162. [Abstract] [PDF]
|
|
|
|
|
|
K Shimamura and J. Rubenstein Inductive interactions direct early regionalization of the mouse forebrain Development, January 7, 1997; 124(14): 2709 - 2718. [Abstract] [PDF]
|
|
|
|
|
|
Y. Onuma, S. Takahashi, M. Asashima, S. Kurata, and W. J. Gehring Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies PNAS, February 19, 2002; 99(4): 2020 - 2025. [Abstract] [Full Text] [PDF]
|
|
