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Development, Vol 124, Issue 3 693-702, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
DA Wettstein, DL Turner and C Kintner
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037-1099, USA.
The X-Notch-1 receptor, and its putative ligand, X-Delta-1, are thought to mediate an inhibitory cell-cell interaction, called lateral inhibition, that limits the number of primary neurons that form in Xenopus embryos. The expression of Xenopus ESR-1, a gene related to Drosophila Enhancer of split, appears to be induced by Notch signaling during this process. To determine how the activation of X-Notch-1 induces ESR-1 expression and regulates primary neurogenesis, we isolated the Xenopus homolog of Suppressor of Hairless (X-Su(H)), a component of the Notch signaling pathway in Drosophila. Using animal cap assays, we show that X-Su(H) induces ESR-1 expression, perhaps directly, when modified by the addition of ankyrin repeats. Using a DNA binding mutant of X-Su(H), we show that X-Su(H) activity is required for induction of ESR-1. Finally, expression of the DNA binding mutant in embryos leads to a neurogenic phenotype as well as increased expression of both X-Delta-1 and XNGNR1, a proneural gene expressed during primary neurogenesis. These results suggest that activation of X-Su(H) is a key step in the Notch signaling pathway during primary neurogenesis in Xenopus embryos.
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E Cau, G Gradwohl, S Casarosa, R Kageyama, and F Guillemot Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium Development, January 6, 2000; 127(11): 2323 - 2332. [Abstract] [PDF]
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W.-C. Jen, V. Gawantka, N. Pollet, C. Niehrs, and C. Kintner Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos Genes & Dev., June 1, 1999; 13(11): 1486 - 1499. [Abstract] [Full Text]
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G. Deblandre, D. Wettstein, N Koyano-Nakagawa, and C Kintner A two-step mechanism generates the spacing pattern of the ciliated cells in the skin of Xenopus embryos Development, January 11, 1999; 126(21): 4715 - 4728. [Abstract] [PDF]
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P Beatus, J Lundkvist, C Oberg, and U Lendahl The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters Development, January 9, 1999; 126(17): 3925 - 3935. [Abstract] [PDF]
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C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]
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C Takke, P Dornseifer, E v Weizsacker, and J. Campos-Ortega her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling Development, January 5, 1999; 126(9): 1811 - 1821. [Abstract] [PDF]
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D Nofziger, A Miyamoto, K. Lyons, and G Weinmaster Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts Development, January 4, 1999; 126(8): 1689 - 1702. [Abstract] [PDF]
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H. K. Kim and G. Siu The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175. [Abstract] [Full Text]
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S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431. [Abstract] [Full Text]
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S. Kidd, T. Lieber, and M. W. Young Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos Genes & Dev., December 1, 1998; 12(23): 3728 - 3740. [Abstract] [Full Text]
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H.-Y. Kao, P. Ordentlich, N. Koyano-Nakagawa, Z. Tang, M. Downes, C. R. Kintner, R. M. Evans, and T. Kadesch A histone deacetylase corepressor complex regulates the Notch signal transduction pathway Genes & Dev., August 1, 1998; 12(15): 2269 - 2277. [Abstract] [Full Text]
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C Bourguignon, J Li, and N Papalopulu XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm Development, January 12, 1998; 125(24): 4889 - 4900. [Abstract] [PDF]
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D. Sparrow, W. Jen, S Kotecha, N Towers, C Kintner, and T. Mohun Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway Development, January 6, 1998; 125(11): 2041 - 2051. [Abstract] [PDF]
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C. Dye, J. Lee, R. Atkinson, R Brewster, P. Han, and H. Bellen The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein Development, January 5, 1998; 125(10): 1845 - 1856. [Abstract] [PDF]
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