|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 4 781-792, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
SJ Butler, S Ray and Y Hiromi
Department of Molecular Biology, Princeton University, NJ 08544, USA.
klingon is a member of the Immunoglobulin superfamily and is expressed in a restricted pattern of neurons during embryonic neurogenesis and in the R7 photoreceptor precursor throughout its development. Starting from the H214 enhancer trap line, we identified a transcription unit, klingon, that encodes a putative protein of 528 amino acids and contains three C2-type Immunoglobulin-like domains followed by one fibronectin type III repeat. When Klingon is expressed in S2 tissue culture cells, it is associated with the cell membrane by a glycosyl-phosphatidylinositol linkage and can mediate homophilic adhesion. Genetic analysis has revealed that klingon is an essential gene that participates in the development of the R7 neuron. Ectopic expression of klingon in all neurons in a sevenless background can alter the position of the R8 rhabdomere.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Stork, S. Thomas, F. Rodrigues, M. Silies, E. Naffin, S. Wenderdel, and C. Klambt Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper Development, April 15, 2009; 136(8): 1251 - 1261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Matsuno, J. Horiuchi, T. Tully, and M. Saitoe The Drosophila cell adhesion molecule Klingon is required for long-term memory formation and is regulated by Notch PNAS, January 6, 2009; 106(1): 310 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vogel, S. A. Teichmann, and C. Chothia The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity Development, December 22, 2003; 130(25): 6317 - 6328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kango-Singh, R. Nolo, C. Tao, P. Verstreken, P. R. Hiesinger, H. J. Bellen, and G. Halder Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila Development, March 14, 2003; 129(24): 5719 - 5730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakamura, D. Baldwin, S. Hannaford, J. Palka, and C. Montell Defective Proboscis Extension Response (DPR), a Member of the Ig Superfamily Required for the Gustatory Response to Salt J. Neurosci., May 1, 2002; 22(9): 3463 - 3472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Duan, J. B. Skeath, and H. T. Nguyen Drosophila Lame duck, a novel member of the Gli superfamily, acts as a key regulator of myogenesis by controlling fusion-competent myoblast development Development, November 15, 2001; 128(22): 4489 - 4500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hirose, N. Ohshima, M. Shiraki, Y. H. Inoue, O. Taguchi, Y. Nishi, A. Matsukage, and M. Yamaguchi Ectopic Expression of DREF Induces DNA Synthesis, Apoptosis, and Unusual Morphogenesis in the Drosophila Eye Imaginal Disc: Possible Interaction with Polycomb and trithorax Group Proteins Mol. Cell. Biol., November 1, 2001; 21(21): 7231 - 7242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Marg, P. Sirim, F. Spaltmann, A. Plagge, G. Kauselmann, F. Buck, F. G. Rathjen, and T. Brummendorf Neurotractin, A Novel Neurite Outgrowth-promoting Ig-like Protein that Interacts with CEPU-1 and LAMP J. Cell Biol., May 17, 1999; 145(4): 865 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Balint-Kurti, G. Ginsburg, J Liu, and A. Kimmel Non-autonomous regulation of a graded, PKA-mediated transcriptional activation signal for cell patterning Development, January 10, 1998; 125(20): 3947 - 3954. [Abstract] [PDF]
|
|
|
|
|
|
G Begemann, N Paricio, R Artero, I Kiss, M Perez-Alonso, and M Mlodzik muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins Development, January 11, 1997; 124(21): 4321 - 4331. [Abstract] [PDF]
|
|
|
|
|
|
D. Nguyen, Y Liu, M. Litsky, and R Reinke The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye Development, January 9, 1997; 124(17): 3303 - 3312. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Llano, A. M. Pendas, P. Aza-Blanc, T. B. Kornberg, and C. Lopez-Otin Dm1-MMP, a Matrix Metalloproteinase from Drosophila with a Potential Role in Extracellular Matrix Remodeling during Neural Development J. Biol. Chem., November 10, 2000; 275(46): 35978 - 35985. [Abstract] [Full Text] [PDF]
|
|
