|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 4 805-816, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
C Pittack, GB Grunwald and TA Reh
Department of Biological Structure SM-20, University of Washington, Seattle 98195, USA.
During eye development, optic vesicles evaginate laterally from the neural tube and develop into two bilayered eye cups that are composed of an outer pigment epithelium layer and an inner neural retina layer. Despite their similar embryonic origin, the pigment epithelium and neural retina differentiate into two very distinct tissues. Previous studies have demonstrated that the developmental potential of the pigmented epithelial cells is not completely restricted; until embryonic day 4.5 in chick embryos, the cells are able to switch their phenotype and differentiate into neural retina when treated with fibroblast growth factors (FGF) (Park, C. M., and Hollenberg, M. J. (1989). Dev. Biol. 134, 201-205; Pittack, C., Jones, M., and Reh, T. A. 1991). Development 113, 577-588; Guillemot, F. and Cepko, C. L. (1992). Development 114, 743-754). These studies motivated us to test whether FGF is necessary for neural retina differentiation during the initial stages of eye cup development. Optic vesicles from embryonic day 1.5 chick were cultured for 24 hours as explants in the presence of FGF or neutralizing antibodies to FGF2. The cultured optic vesicles formed eye cups that contained a lens vesicle, neural retina and pigmented epithelium, based on morphology and expression of neural and pigmented epithelium-specific antigens. Addition of FGF to the optic vesicles caused the presumptive pigmented epithelium to undergo neuronal differentiation and, as a consequence, a double retina was formed. By contrast, neutralizing antibodies to FGF2 blocked neural differentiation in the presumptive neural retina, without affecting pigmented epithelial cell differentiation. These data, along with evidence for expression of several FGF family members and their receptors in the developing eye, indicate that members of the FGF family may be required for establishing the distinction between the neural retina and pigmented epithelium in the optic vesicle.
This article has been cited by other articles:
|
|
 |
|
  O. Parolini, F. Alviano, G. P. Bagnara, G. Bilic, H.-J. Buhring, M. Evangelista, S. Hennerbichler, B. Liu, M. Magatti, N. Mao, et al. Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells Stem Cells, February 1, 2008; 26(2): 300 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Muller, H. Rohrer, and A. Vogel-Hopker Bone morphogenetic proteins specify the retinal pigment epithelium in the chick embryo Development, October 1, 2007; 134(19): 3483 - 3493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liang, R.-T. Yan, W. Ma, H. Zhang, and S.-Z. Wang Exploring RPE as a Source of Photoreceptors: Differentiation and Integration of Transdifferentiating Cells Grafted into Embryonic Chick Eyes Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 5066 - 5074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Inoue, T. Kagawa, M. Fukushima, T. Shimizu, Y. Yoshinaga, S. Takada, H. Tanihara, and T. Taga Activation of Canonical Wnt Pathway Promotes Proliferation of Retinal Stem Cells Derived from Adult Mouse Ciliary Margin Stem Cells, January 1, 2006; 24(1): 95 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Picker and M. Brand Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina Development, November 15, 2005; 132(22): 4951 - 4962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Azuma, K. Tadokoro, A. Asaka, M. Yamada, Y. Yamaguchi, H. Handa, S. Matsushima, T. Watanabe, Y. Kida, T. Ogura, et al. Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor Hum. Mol. Genet., April 15, 2005; 14(8): 1059 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Schulte, M. A. Peters, J. Sen, and C. L. Cepko The Rod Photoreceptor Pattern Is Set at the Optic Vesicle Stage and Requires Spatially Restricted cVax Expression J. Neurosci., March 16, 2005; 25(11): 2823 - 2831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Murali, S. Yoshikawa, R. R. Corrigan, D. J. Plas, M. C. Crair, G. Oliver, K. M. Lyons, Y. Mishina, and Y. Furuta Distinct developmental programs require different levels of Bmp signaling during mouse retinal development Development, March 1, 2005; 132(5): 913 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Planque, G. Raposo, L. Leconte, O. Anezo, P. Martin, and S. Saule Microphthalmia Transcription Factor Induces Both Retinal Pigmented Epithelium and Neural Crest Melanocytes from Neuroretina Cells J. Biol. Chem., October 1, 2004; 279(40): 41911 - 41917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Spence, M. Madhavan, J. D. Ewing, D. K. Jones, B. M. Lehman, and K. Del Rio-Tsonis The hedgehog pathway is a modulator of retina regeneration Development, September 15, 2004; 131(18): 4607 - 4621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Dorrell, E. Aguilar, C. Weber, and M. Friedlander Global Gene Expression Analysis of the Developing Postnatal Mouse Retina Invest. Ophthalmol. Vis. Sci., March 1, 2004; 45(3): 1009 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Baumer, T. Marquardt, A. Stoykova, D. Spieler, D. Treichel, R. Ashery-Padan, and P. Gruss Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6 Development, July 1, 2003; 130(13): 2903 - 2915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Dakubo, Y. P. Wang, C. Mazerolle, K. Campsall, A. P. McMahon, and V. A. Wallace Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development Development, July 1, 2003; 130(13): 2967 - 2980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Martinez-Morales, V. Dolez, I. Rodrigo, R. Zaccarini, L. Leconte, P. Bovolenta, and S. Saule OTX2 Activates the Molecular Network Underlying Retina Pigment Epithelium Differentiation J. Biol. Chem., June 6, 2003; 278(24): 21721 - 21731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Van Hoffelen, M. J. Young, M. A. Shatos, and D. S. Sakaguchi Incorporation of Murine Brain Progenitor Cells into the Developing Mammalian Retina Invest. Ophthalmol. Vis. Sci., January 1, 2003; 44(1): 426 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Fischer, C. R. McGuire, B. D. Dierks, and T. A. Reh Insulin and Fibroblast Growth Factor 2 Activate a Neurogenic Program in Muller Glia of the Chicken Retina J. Neurosci., November 1, 2002; 22(21): 9387 - 9398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Fischer, B. D. Dierks, and T. A. Reh Exogenous growth factors induce the production of ganglion cells at the retinal margin Development, January 5, 2002; 129(9): 2283 - 2291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Mu, S. Zhao, R. Pershad, T.-F. Hsieh, A. Scarpa, S. W. Wang, R. A. White, P. D. Beremand, T. L. Thomas, L. Gan, et al. Gene expression in the developing mouse retina by EST sequencing and microarray analysis Nucleic Acids Res., December 15, 2001; 29(24): 4983 - 4993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhao, F.-C. Hung, J. S. Colvin, A. White, W. Dai, F. J. Lovicu, D. M. Ornitz, and P. A. Overbeek Patterning the optic neuroepithelium by FGF signaling and Ras activation Development, December 15, 2001; 128(24): 5051 - 5060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Caffé, A. K. Söderpalm, I. Holmqvist, and T. van Veen A Combination of CNTF and BDNF Rescues rd Photoreceptors but Changes Rod Differentiation in the Presence of RPE in Retinal Explants Invest. Ophthalmol. Vis. Sci., January 1, 2001; 42(1): 275 - 282. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. Tropepe, B. L. Coles, B. J. Chiasson, D. J. Horsford, A. J. Elia, R. R. McInnes, and D. van der Kooy Retinal Stem Cells in the Adult Mammalian Eye Science, March 17, 2000; 287(5460): 2032 - 2036. [Abstract] [Full Text]
|
|
|
|
|
|
S Fuhrmann, E. Levine, and T. Reh Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick Development, January 11, 2000; 127(21): 4599 - 4609. [Abstract] [PDF]
|
|
|
|
|
|
M Nguyen and H Arnheiter Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF Development, January 8, 2000; 127(16): 3581 - 3591. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Planque, N. Turque, K. Opdecamp, M. Bailly, P. Martin, and S. Saule Expression of the Microphthalmia-associated Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Miin Avian Neuroretina Cells Induces aPigmented Phenotype Cell Growth Differ., July 1, 1999; 10(7): 525 - 536. [Abstract] [Full Text]
|
|
|
|
|
|
K. McCabe, E. Gunther, and T. Reh The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation Development, January 12, 1999; 126(24): 5713 - 5724. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Toy, J.-M. Yang, G. S. Leppert, and O. H. Sundin The Optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes PNAS, September 1, 1998; 95(18): 10643 - 10648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S McFarlane, M. Zuber, and C. Holt A role for the fibroblast growth factor receptor in cell fate decisions in the developing vertebrate retina Development, January 10, 1998; 125(20): 3967 - 3975. [Abstract] [PDF]
|
|
|
|
|
|
J Hyer, T Mima, and T Mikawa FGF1 patterns the optic vesicle by directing the placement of the neural retina domain Development, January 3, 1998; 125(5): 869 - 877. [Abstract] [PDF]
|
|
|
|
|
|
E. M. Levine, H. Roelink, J. Turner, and T. A. Reh Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro J. Neurosci., August 15, 1997; 17(16): 6277 - 6288. [Abstract] [Full Text] [PDF]
|
|
