|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 5 1033-1044, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
I Varlet, J Collignon and EJ Robertson
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Mouse nodal, a member of the TGFbeta family of secreted growth factors is essential for gastrulation. We recently generated a nodal(lacZ) reporter allele by homologous recombination in ES cells. In the present study, beta-galactosidase staining in the perigastrulation-stage embryo has demonstrated the site of highest nodal expression is localised to the prospective posterior region of the epiblast marking the site of primitive streak formation. We also documented transient nodal.lacZ expression in the visceral endoderm prior to and during early streak formation. A mosaic analysis using wild-type ES cells to rescue nodal-deficient embryos allowed us to document functionally distinct nodal activities in the embryonic ectodermal and primitive endodermal cell lineages. nodal signaling in the ectoderm is necessary for primitive streak formation as the gastrulation defect of nodal-deficient embryos can be rescued by the inclusion of small numbers of wild-type cells. In addition, we show that chimeric embryos composed of nodal-deficient primitive endoderm fail to develop rostral neural structures. Thus we conclude that the action of nodal, a TGFbeta-related growth factor expressed in the primitive endoderm, is critical for patterning of the anterior aspects of the A-P axis.
This article has been cited by other articles:
|
|
 |
|
  D. D'Andrea, G. L. Liguori, J. A. Le Good, E. Lonardo, O. Andersson, D. B. Constam, M. G. Persico, and G. Minchiotti Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction J. Cell Biol., February 6, 2008; 180(3): 597 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wanderling, B. B. Simen, O. Ostrovsky, N. T. Ahmed, S. M. Vogen, T. Gidalevitz, and Y. Argon GRP94 Is Essential for Mesoderm Induction and Muscle Development Because It Regulates Insulin-like Growth Factor Secretion Mol. Biol. Cell, October 1, 2007; 18(10): 3764 - 3775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Di-Gregorio, M. Sancho, D. W. Stuckey, L. A. Crompton, J. Godwin, Y. Mishina, and T. A. Rodriguez BMP signalling inhibits premature neural differentiation in the mouse embryo Development, September 15, 2007; 134(18): 3359 - 3369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kimura-Yoshida, E. Tian, H. Nakano, S. Amazaki, K. Shimokawa, J. Rossant, S. Aizawa, and I. Matsuo Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes PNAS, April 3, 2007; 104(14): 5919 - 5924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mesnard, M. Guzman-Ayala, and D. B. Constam Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning Development, July 1, 2006; 133(13): 2497 - 2505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jouneau, Q. Zhou, A. Camus, V. Brochard, L. Maulny, J. Collignon, and J.-P. Renard Developmental abnormalities of NT mouse embryos appear early after implantation. Development, April 1, 2006; 133(8): 1597 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Georgiades and J. Rossant Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development Development, March 15, 2006; 133(6): 1059 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Forrai, K. Boyle, A. H. Hart, L. Hartley, S. Rakar, T. A. Willson, K. M. Simpson, A. W. Roberts, W. S. Alexander, A. K. Voss, et al. Absence of Suppressor of Cytokine Signalling 3 Reduces Self-Renewal and Promotes Differentiation in Murine Embryonic Stem Cells Stem Cells, March 1, 2006; 24(3): 604 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tada, T. Era, C. Furusawa, H. Sakurai, S. Nishikawa, M. Kinoshita, K. Nakao, T. Chiba, and S.-I. Nishikawa Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture Development, October 1, 2005; 132(19): 4363 - 4374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Rodriguez, S. Srinivas, M. P. Clements, J. C. Smith, and R. S. P. Beddington Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm Development, June 1, 2005; 132(11): 2513 - 2520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gotoh, K. Manova, S. Tanaka, M. Murohashi, Y. Hadari, A. Lee, Y. Hamada, T. Hiroe, M. Ito, T. Kurihara, et al. The Docking Protein FRS2{alpha} Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development Mol. Cell. Biol., May 15, 2005; 25(10): 4105 - 4116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Stern Neural induction: old problem, new findings, yet more questions Development, May 1, 2005; 132(9): 2007 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Yan, J. Willoughby, D. Liu, J. G. Crump, C. Wilson, C. T. Miller, A. Singer, C. Kimmel, M. Westerfield, and J. H. Postlethwait A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development Development, March 1, 2005; 132(5): 1069 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Foley and M. Mercola Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex Genes & Dev., February 1, 2005; 19(3): 387 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Dunn, C. H. Koonce, D. C. Anderson, A. Islam, E. K. Bikoff, and E. J. Robertson Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile Genes & Dev., January 1, 2005; 19(1): 152 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guzman-Ayala, N. Ben-Haim, S. Beck, and D. B. Constam Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment PNAS, November 2, 2004; 101(44): 15656 - 15660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bertocchini, I. Skromne, L. Wolpert, and C. D. Stern Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo Development, July 15, 2004; 131(14): 3381 - 3390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. G. Kelly, K. I. Pinson, and W. C. Skarnes The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice Development, June 15, 2004; 131(12): 2803 - 2815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Dunn, S. D. Vincent, L. Oxburgh, E. J. Robertson, and E. K. Bikoff Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo Development, April 15, 2004; 131(8): 1717 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. L. Tam and J. Rossant Mouse embryonic chimeras: tools for studying mammalian development Development, December 22, 2003; 130(25): 6155 - 6163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Morkel, J. Huelsken, M. Wakamiya, J. Ding, M. van de Wetering, H. Clevers, M. M. Taketo, R. R. Behringer, M. M. Shen, and W. Birchmeier {beta}-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation Development, December 22, 2003; 130(25): 6283 - 6294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Fehling, G. Lacaud, A. Kubo, M. Kennedy, S. Robertson, G. Keller, and V. Kouskoff Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation Development, September 1, 2003; 130(17): 4217 - 4227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Vincent, N. R. Dunn, S. Hayashi, D. P. Norris, and E. J. Robertson Cell fate decisions within the mouse organizer are governed by graded Nodal signals Genes & Dev., July 1, 2003; 17(13): 1646 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Halilagic, M. H. Zile, and M. Studer A novel role for retinoids in patterning the avian forebrain during presomite stages Development, May 15, 2003; 130(10): 2039 - 2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Dougan, R. M. Warga, D. A. Kane, A. F. Schier, and W. S. Talbot The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm Development, May 1, 2003; 130(9): 1837 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Norris, J. Brennan, E. K. Bikoff, and E. J. Robertson The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo Development, March 9, 2003; 129(14): 3455 - 3468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mukhopadhyay, A. Teufel, T. Yamashita, A. D. Agulnick, L. Chen, K. M. Downs, A. Schindler, A. Grinberg, S.-P. Huang, D. Dorward, et al. Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation Development, February 1, 2003; 130(3): 495 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Avilion, S. K. Nicolis, L. H. Pevny, L. Perez, N. Vivian, and R. Lovell-Badge Multipotent cell lineages in early mouse development depend on SOX2 function Genes & Dev., January 1, 2003; 17(1): 126 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chang, C. W. Brown, and M. M. Matzuk Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily Endocr. Rev., December 1, 2002; 23(6): 787 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Oh, C.-Y. Yeo, Y. Lee, H. Schrewe, M. Whitman, and E. Li Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning Genes & Dev., November 1, 2002; 16(21): 2749 - 2754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Hanna, R. K. Foreman, I. A. Tarasenko, D. S. Kessler, and P. A. Labosky Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo Genes & Dev., October 15, 2002; 16(20): 2650 - 2661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Hart, L. Hartley, K. Sourris, E. S. Stadler, R. Li, E. G. Stanley, P. P. L. Tam, A. G. Elefanty, and L. Robb Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo Development, August 1, 2002; 129(15): 3597 - 3608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-T. Yan, J.-J. Liu, Y. Luo, C. E, R. S. Haltiwanger, C. Abate-Shen, and M. M. Shen Dual Roles of Cripto as a Ligand and Coreceptor in the Nodal Signaling Pathway Mol. Cell. Biol., July 1, 2002; 22(13): 4439 - 4449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Yamamoto, C. Takagi, A. C. Hyodo, and N. Ueno Suppression of head formation by Xmsx-1 through the inhibition of intracellular nodal signaling Development, July 15, 2001; 128(14): 2769 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh, and H. Hamada The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse Genes & Dev., May 15, 2001; 15(10): 1242 - 1256. [Abstract] [Full Text]
|
|
|
|
|
|
P. A. Hoodless, M. Pye, C. Chazaud, E. Labbé, L. Attisano, J. Rossant, and J. L. Wrana FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse Genes & Dev., May 15, 2001; 15(10): 1257 - 1271. [Abstract] [Full Text]
|
|
|
|
|
|
L. Lowe, S Yamada, and M. Kuehn Genetic dissection of nodal function in patterning the mouse embryo Development, January 5, 2001; 128(10): 1831 - 1843. [Abstract] [PDF]
|
|
|
|
|
|
A Perea-Gomez, K. Lawson, M Rhinn, L Zakin, P Brulet, S Mazan, and S. Ang Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo Development, January 3, 2001; 128(5): 753 - 765. [Abstract] [PDF]
|
|
|
|
|
|
D. B. Constam and E. J. Robertson SPC4/PACE4 regulates a TGFbeta signaling network during axis formation Genes & Dev., May 1, 2000; 14(9): 1146 - 1155. [Abstract] [Full Text]
|
|
|
|
|
|
J. Huelsken, R. Vogel, V. Brinkmann, B. Erdmann, C. Birchmeier, and W. Birchmeier Requirement for {beta}-Catenin in Anterior-Posterior Axis Formation in Mice J. Cell Biol., February 7, 2000; 148(3): 567 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Foley, I Skromne, and C. Stern Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast Development, January 9, 2000; 127(17): 3839 - 3854. [Abstract] [PDF]
|
|
|
|
|
|
L Saude, K Woolley, P Martin, W Driever, and D. Stemple Axis-inducing activities and cell fates of the zebrafish organizer Development, January 8, 2000; 127(16): 3407 - 3417. [Abstract] [PDF]
|
|
|
|
|
|
K. Tremblay, P. Hoodless, E. Bikoff, and E. Robertson Formation of the definitive endoderm in mouse is a Smad2-dependent process Development, January 7, 2000; 127(14): 3079 - 3090. [Abstract] [PDF]
|
|
|
|
|
|
J. Martinez Barbera, M Clements, P Thomas, T Rodriguez, D Meloy, D Kioussis, and R. Beddington The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation Development, January 6, 2000; 127(11): 2433 - 2445. [Abstract] [PDF]
|
|
|
|
|
|
H. Sirotkin, S. Dougan, A. Schier, and W. Talbot bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish Development, January 6, 2000; 127(12): 2583 - 2592. [Abstract] [PDF]
|
|
|
|
|
|
A Camus, B. Davidson, S Billiards, P Khoo, J. Rivera-Perez, M Wakamiya, R. Behringer, and P. Tam The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo Development, January 5, 2000; 127(9): 1799 - 1813. [Abstract] [PDF]
|
|
|
|
|
|
J. Wells and D. Melton Early mouse endoderm is patterned by soluble factors from adjacent germ layers Development, January 4, 2000; 127(8): 1563 - 1572. [Abstract] [PDF]
|
|
|
|
|
|
L Mathis and J. Nicolas Different clonal dispersion in the rostral and caudal mouse central nervous system Development, January 3, 2000; 127(6): 1277 - 1290. [Abstract] [PDF]
|
|
|
|
|
|
D. Constam and E. Robertson Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping Development, January 1, 2000; 127(2): 245 - 254. [Abstract] [PDF]
|
|
|
|
|
|
J. Heyer, D. Escalante-Alcalde, M. Lia, E. Boettinger, W. Edelmann, C. L. Stewart, and R. Kucherlapati Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis PNAS, October 26, 1999; 96(22): 12595 - 12600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Sun, E. N. Meyers, M. Lewandoski, and G. R. Martin Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo Genes & Dev., July 15, 1999; 13(14): 1834 - 1846. [Abstract] [Full Text]
|
|
|
|
|
|
H. Adachi, Y. Saijoh, K. Mochida, S. Ohishi, H. Hashiguchi, A. Hirao, and H. Hamada Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer Genes & Dev., June 15, 1999; 13(12): 1589 - 1600. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Lawson, N. R. Dunn, B. A.J. Roelen, L. M. Zeinstra, A. M. Davis, C. V.E. Wright, J. P.W.F.M. Korving, and B. L.M. Hogan Bmp4 is required for the generation of primordial germ cells in the mouse embryo Genes & Dev., February 15, 1999; 13(4): 424 - 436. [Abstract] [Full Text]
|
|
|
|
|
|
W Shawlot, M Wakamiya, K. Kwan, A Kania, T. Jessell, and R. Behringer Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse Development, January 11, 1999; 126(22): 4925 - 4932. [Abstract] [PDF]
|
|
|
|
|
|
P. Tam and K. Steiner Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo Development, January 11, 1999; 126(22): 5171 - 5179. [Abstract] [PDF]
|
|
|
|
|
|
D Brown, D Wagner, X Li, J. Richardson, and E. Olson Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis Development, January 10, 1999; 126(19): 4317 - 4329. [Abstract] [PDF]
|
|
|
|
|
|
A Perea-Gomez, W Shawlot, H Sasaki, R. Behringer, and S Ang HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo Development, January 10, 1999; 126(20): 4499 - 4511. [Abstract] [PDF]
|
|
|
|
|
|
S. Osada and C. Wright Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis Development, January 6, 1999; 126(14): 3229 - 3240. [Abstract] [PDF]
|
|
|
|
|
|
K Fekany, Y Yamanaka, T Leung, H. Sirotkin, J Topczewski, M. Gates, M Hibi, A Renucci, D Stemple, A Radbill, et al. The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures Development, January 4, 1999; 126(7): 1427 - 1438. [Abstract] [PDF]
|
|
|
|
|
|
K Hentges, K Thompson, and A Peterson The flat-top gene is required for the expansion and regionalization of the telencephalic primordium Development, January 4, 1999; 126(8): 1601 - 1609. [Abstract] [PDF]
|
|
|
|
|
|
E Coucouvanis and G. Martin BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo Development, January 2, 1999; 126(3): 535 - 546. [Abstract] [PDF]
|
|
|
|
|
|
M Koutsourakis, A Langeveld, R Patient, R Beddington, and F Grosveld The transcription factor GATA6 is essential for early extraembryonic development Development, January 2, 1999; 126(4): 723 - 732. [Abstract] [PDF]
|
|
|
|
|
|
H Knoetgen, C Viebahn, and M Kessel Head induction in the chick by primitive endoderm of mammalian, but not avian origin Development, January 2, 1999; 126(4): 815 - 825. [Abstract] |
