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Development, Vol 124, Issue 6 1139-1148, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
JL de la Pompa, A Wakeham, KM Correia, E Samper, S Brown, RJ Aguilera, T Nakano, T Honjo, TW Mak, J Rossant and RA Conlon
Amgen Institute, Toronto, Ontario, Canada. Jose.delaPompa@amgen.com
The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation, but a function in neurogenesis and in cell fate decisions has not been shown. Here we show that these mutations lead to altered expression of the Notch signalling pathway homologues Hes-5, Mash-1 and Dll1, resulting in enhanced neurogenesis. Precocious neuronal differentiation is indicated by the expanded expression domains of Math4A, neuroD and NSCL-1. The RBP-Jk mutation has stronger effects on expression of these genes than does the Notch1 mutation, consistent with functional redundancy of Notch genes in neurogenesis. Our results demonstrate conservation of the Notch pathway and its regulatory mechanisms from fly to mouse, and support a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation.
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L. J. Strobl, H. Höfelmayr, G. Marschall, M. Brielmeier, G. W. Bornkamm, and U. Zimber-Strobl Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2 J. Virol., February 15, 2000; 74(4): 1727 - 1735. [Abstract] [Full Text]
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V Dubreuil, M Hirsch, A Pattyn, J Brunet, and C Goridis The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity Development, January 12, 2000; 127(23): 5191 - 5201. [Abstract] [PDF]
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M. Rones, K. McLaughlin, M Raffin, and M Mercola Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis Development, January 9, 2000; 127(17): 3865 - 3876. [Abstract] [PDF]
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T Ito, N Udaka, T Yazawa, K Okudela, H Hayashi, T Sudo, F Guillemot, R Kageyama, and H Kitamura Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium Development, January 9, 2000; 127(18): 3913 - 3921. [Abstract] [PDF]
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A Zine, T. Van De Water, and F de Ribaupierre Notch signaling regulates the pattern of auditory hair cell differentiation in mammals Development, January 8, 2000; 127(15): 3373 - 3383. [Abstract] [PDF]
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T Kondo and M Raff Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation Development, January 7, 2000; 127(14): 2989 - 2998. [Abstract] [PDF]
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E Cau, G Gradwohl, S Casarosa, R Kageyama, and F Guillemot Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium Development, January 6, 2000; 127(11): 2323 - 2332. [Abstract] [PDF]
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M Hojo, T Ohtsuka, N Hashimoto, G Gradwohl, F Guillemot, and R Kageyama Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina Development, January 6, 2000; 127(12): 2515 - 2522. [Abstract] [PDF]
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M Handler, X Yang, and J Shen Presenilin-1 regulates neuronal differentiation during neurogenesis Development, January 6, 2000; 127(12): 2593 - 2606. [Abstract] [PDF]
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C. Fode, Q. Ma, S. Casarosa, S.-L. Ang, D. J. Anderson, and F. Guillemot A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons Genes & Dev., January 1, 2000; 14(1): 67 - 80. [Abstract] [Full Text]
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J Bao, D. Talmage, L. Role, and J Gautier Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins Development, January 1, 2000; 127(2): 425 - 435. [Abstract] [PDF]
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D. B. Donoviel, A.-K. Hadjantonakis, M. Ikeda, H. Zheng, P. S. G. Hyslop, and A. Bernstein Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects Genes & Dev., November 1, 1999; 13(21): 2801 - 2810. [Abstract] [Full Text]
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B. H. Jennings, D. M. Tyler, and S. J. Bray Target Specificities of Drosophila Enhancer of split Basic Helix-Loop-Helix Proteins Mol. Cell. Biol., July 1, 1999; 19(7): 4600 - 4610. [Abstract] [Full Text] [PDF]
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 M. P. Felli, M. Maroder, T. A. Mitsiadis, A. F. Campese, D. Bellavia, A. Vacca, R. S. Mann, L. Frati, U. Lendahl, A. Gulino, et al. Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development Int. Immunol., July 1, 1999; 11(7): 1017 - 1025. [Abstract] [Full Text] [PDF]
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J. Wilson-Rawls, J. D. Molkentin, B. L. Black, and E. N. Olson Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C Mol. Cell. Biol., April 1, 1999; 19(4): 2853 - 2862. [Abstract] [Full Text] [PDF]
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K. Kuroda, S. Tani, K. Tamura, S. Minoguchi, H. Kurooka, and T. Honjo Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis J. Biol. Chem., March 12, 1999; 274(11): 7238 - 7244. [Abstract] [Full Text] [PDF]
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B. Riley, M Chiang, L Farmer, and R Heck The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1 Development, January 12, 1999; 126(24): 5669 - 5678. [Abstract] [PDF]
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K. Klueg and M. Muskavitch Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila J. Cell Sci., January 10, 1999; 112(19): 3289 - 3297. [Abstract] [PDF]
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P Beatus, J Lundkvist, C Oberg, and U Lendahl The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters Development, January 9, 1999; 126(17): 3925 - 3935. [Abstract] [PDF]
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Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality Development, January 8, 1999; 126(15): 3415 - 3424. [Abstract] [PDF]
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C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]
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D Nofziger, A Miyamoto, K. Lyons, and G Weinmaster Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts Development, January 4, 1999; 126(8): 1689 - 1702. [Abstract] [PDF]
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M. Torii, F Matsuzaki, N Osumi, K Kaibuchi, S Nakamura, S Casarosa, F Guillemot, and M Nakafuku Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system Development, January 2, 1999; 126(3): 443 - 456. [Abstract] [PDF]
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S Casarosa, C Fode, and F Guillemot Mash1 regulates neurogenesis in the ventral telencephalon Development, January 2, 1999; 126(3): 525 - 534. [Abstract] [PDF]
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