|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 7 1263-1274, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
PA Labosky, GE Winnier, TL Jetton, L Hargett, AK Ryan, MG Rosenfeld, AF Parlow and BL Hogan
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA. plabosky@mail.med.upenn.edu
The mouse Mf3 gene, also known as Fkh5 and HFH-e5.1, encodes a winged helix/forkhead transcription factor. In the early embryo, transcripts for Mf3 are restricted to the presomitic mesoderm and anterior neurectoderm and mesoderm. By 9.5 days post coitum, expression in the nervous system is predominantly in the diencephalon, midbrain and neural tube. After midgestation, the highest level of mRNA is in the mammillary bodies, the posterior-most part of the hypothalamus. Mice homozygous for a deletion of the mf3 locus on a [129 x Black Swiss] background display variable phenotypes consistent with a requirement for the gene at several stages of embryonic and postnatal development. Approximately six percent of the mf3-/- embryos show an open neural tube in the diencephalon and midbrain region, and another five percent show a severe reduction of the posterior body axis; both these classes of affected embryos die in utero. Surviving homozygotes have an apparently normal phenotype at birth. Postnatally, however, mf3-/- pups are severely growth retarded and approximately one third die before weaning. This growth defect is not a direct result of lack of circulating growth hormone or thyrotropin. Mice that survive to weaning are healthy, but they show an abnormal clasping of the hindfeet when suspended by the tail. Although much smaller than normal, the mice are fertile. However, mf3-/- females cannot eject their milk supply to feed their pups. This nursing defect can be corrected with interperitoneal injections of oxytocin. These results provide evidence that Mf3 is required for normal hypothalamus development and suggest that Mf3 may play a role in postnatal growth and lactation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  N.-E. Szabo, T. Zhao, M. Cankaya, T. Theil, X. Zhou, and G. Alvarez-Bolado Role of Neuroepithelial Sonic hedgehog in Hypothalamic Patterning J. Neurosci., May 27, 2009; 29(21): 6989 - 7002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liljander, M.-A. Sallstrom, S. Andersson, P. Wernhoff, A. Andersson, R. Holmdahl, and R. Mattsson Identification of Genetic Regions of Importance for Reproductive Performance in Female Mice Genetics, June 1, 2006; 173(2): 901 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Heglind, A. Cederberg, J. Aquino, G. Lucas, P. Ernfors, and S. Enerback Lack of the Central Nervous System- and Neural Crest-Expressed Forkhead Gene Foxs1 Affects Motor Function and Body Weight Mol. Cell. Biol., July 1, 2005; 25(13): 5616 - 5625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Collins, Y.-F. Lee, C. A. Heinlein, N.-C. Liu, Y.-T. Chen, C.-R. Shyr, C. K. Meshul, H. Uno, K. A. Platt, and C. Chang Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4 PNAS, October 19, 2004; 101(42): 15058 - 15063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ohtoshi and R. R. Behringer Neonatal Lethality, Dwarfism, and Abnormal Brain Development in Dmbx1 Mutant Mice Mol. Cell. Biol., September 1, 2004; 24(17): 7548 - 7558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Juan and F. H. Ruddle Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer Development, October 15, 2003; 130(20): 4823 - 4834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Liu, A. Lyubarsky, J. H. Skalet, E. N. Pugh Jr, and E. A. Pierce RP1 Is Required for the Correct Stacking of Outer Segment Discs Invest. Ophthalmol. Vis. Sci., October 1, 2003; 44(10): 4171 - 4183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C.Y. Wong, N. Alon, C. Mckerlie, J. R. Huang, M. S. Meyn, and M. Buchwald Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia Hum. Mol. Genet., August 15, 2003; 12(16): 2063 - 2076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Peripato, R. A. de Brito, T. T. Vaughn, L. S. Pletscher, S. R. Matioli, and J. M. Cheverud Quantitative Trait Loci for Maternal Performance for Offspring Survival in Mice Genetics, November 1, 2002; 162(3): 1341 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Lee, N. Perreault, J. E. Brestelli, and K. H. Kaestner Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity Genes & Dev., June 15, 2002; 16(12): 1488 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Katz, N. Perreault, B. G. Goldstein, C. S. Lee, P. A. Labosky, V. W. Yang, and K. H. Kaestner The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon Development, January 6, 2002; 129(11): 2619 - 2628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. H. Burbach, S. M. Luckman, D. Murphy, and H. Gainer Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System Physiol Rev, July 1, 2001; 81(3): 1197 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. She, M. Shiota, K. D. Shelton, R. Chalkley, C. Postic, and M. A. Magnuson Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism Mol. Cell. Biol., September 1, 2000; 20(17): 6508 - 6517. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kume, K. Deng, and B. L. M. Hogan Minimal Phenotype of Mice Homozygous for a Null Mutation in the Forkhead/Winged Helix Gene, Mf2 Mol. Cell. Biol., February 15, 2000; 20(4): 1419 - 1425. [Abstract] [Full Text]
|
|
|
|
|
|
T Kume, K Deng, and B. Hogan Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract Development, January 4, 2000; 127(7): 1387 - 1395. [Abstract] [PDF]
|
|
|
|
|
|
G Alvarez-Bolado, X Zhou, A. Voss, T Thomas, and P Gruss Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus Development, January 3, 2000; 127(5): 1029 - 1038. [Abstract] [PDF]
|
|
|
|
|
|
P Daubas, S Tajbakhsh, J Hadchouel, M Primig, and M Buckingham Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons Development, January 1, 2000; 127(2): 319 - 331. [Abstract] [PDF]
|
|
|
|
|
|
T. Clark, S. Conway, I. Scott, P. Labosky, G Winnier, J Bundy, B. Hogan, and D. Greenspan The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart Development, January 6, 1999; 126(12): 2631 - 2642. [Abstract] [PDF]
|
|
|
|
|
|
B. Liu, C.-L. Dou, L. Prabhu, and E. Lai FAST-2 Is a Mammalian Winged-Helix Protein Which Mediates Transforming Growth Factor beta Signals Mol. Cell. Biol., January 1, 1999; 19(1): 424 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Dean, R. R. Berger, and M. M. Sanders A Winged-Helix Family Member Is Involved in a Steroid Hormone-Triggered Regulatory Circuit Endocrinology, December 1, 1998; 139(12): 4967 - 4975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hellqvist, M. Mahlapuu, A. Blixt, S. Enerback, and P. Carlsson The Human Forkhead Protein FREAC-2 Contains Two Functionally Redundant Activation Domains and Interacts with TBP and TFIIB J. Biol. Chem., September 4, 1998; 273(36): 23335 - 23343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Pelletier, S. L. Brody, H. Liapis, R. A. White, and B. P. Hackett A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium Am J Physiol Lung Cell Mol Physiol, March 1, 1998; 274(3): L351 - L359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hennighausen and G. W. Robinson Think globally, act locally: the making of a mouse mammary gland Genes & Dev., February 15, 1998; 12(4): 449 - 455. [Full Text]
|
|
|
|
|
|
F. Mariani and R. Harland XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue Development, January 12, 1998; 125(24): 5019 - 5031. [Abstract] [PDF]
|
|
|
|
|
|
Y Grinblat, J Gamse, M Patel, and H Sive Determination of the zebrafish forebrain: induction and patterning Development, January 11, 1998; 125(22): 4403 - 4416. [Abstract] [PDF]
|
|
|
|
|
|
R Wehr, A Mansouri, T de Maeyer, and P Gruss Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body Development, January 11, 1997; 124(22): 4447 - 4456. [Abstract] [PDF]
|
|
