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Development, Vol 124, Issue 7 1313-1322, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
H Sasaki, C Hui, M Nakafuku and H Kondoh
Laboratory of Developmental Biology, Osaka University, Suita, Japan. hsasaki@imcb.osaka-u.ac.jp
The floor plate plays important roles in ventral pattern formation and axonal guidance within the neural tube of vertebrate embryos. A critical event for floor plate development is the induction of a winged helix transcription factor, Hepatocyte Nuclear Factor-3beta (HNF-3beta). The enhancer for floor plate expression of HNF-3beta is located 3' of the transcription unit and consists of multiple elements. HNF-3beta induction depends on the notochord-derived signal, Sonic hedgehog (Shh). Genetic analysis in Drosophila has led to the identification of genes involved in the Hh signalling pathway, and cubitus interruptus (ci), encoding a protein with five zinc finger motifs, was placed downstream. In the present work, we test the involvement of Gli proteins, the mouse homologues of Ci, in activation of the floor plate enhancer of HNF-3beta. Transgenic analysis shows that a Gli-binding site is required for the activity of the minimal floor plate enhancer of HNF-3beta in vivo. Three Gli genes are differentially expressed in the developing neural tube. Gli expression is restricted to the ventral part, while Gli2 and Gli3 are expressed throughout the neural tube and dorsally, respectively. Strong Gli and Gli2, and weak Gli3 expressions transiently overlap with HNF-3beta at the time of its induction. Consistent with ventrally localized expression, Gli expression can be up-regulated by Shh in a cell line. Finally, the Gli-binding site acts as a Shh responsive element, and human GLI, but not GLI3, can activate this binding site in tissue culture. Taken together, these findings suggest that Gli, and probably also Gli2, are good candidates for transcriptional activators of the HNF-3beta floor plate enhancer, and the binding site for Gli proteins is a key element for response to Shh signalling. These results also support the idea that Gli/Ci are evolutionary conserved transcription factors in the Hedgehog signalling pathway.
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H. Sheng, S. Goich, A. Wang, M. Grachtchouk, L. Lowe, R. Mo, K. Lin, F. J. de Sauvage, H. Sasaki, C.-c. Hui, et al. Dissecting the Oncogenic Potential of Gli2: Deletion of an NH2-Terminal Fragment Alters Skin Tumor Phenotype Cancer Res., September 15, 2002; 62(18): 5308 - 5316. [Abstract] [Full Text] [PDF]
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J. Mao, P. Maye, P. Kogerman, F. J. Tejedor, R. Toftgard, W. Xie, G. Wu, and D. Wu Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1 J. Biol. Chem., September 13, 2002; 277(38): 35156 - 35161. [Abstract] [Full Text] [PDF]
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E. C. Bailey, L. Milenkovic, M. P. Scott, J. F. Collawn, and R. L. Johnson Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts J. Biol. Chem., September 6, 2002; 277(37): 33632 - 33640. [Abstract] [Full Text] [PDF]
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M.-T. Teh, S.-T. Wong, G. W. Neill, L. R. Ghali, M. P. Philpott, and A. G. Quinn FOXM1 Is a Downstream Target of Gli1 in Basal Cell Carcinomas Cancer Res., August 15, 2002; 62(16): 4773 - 4780. [Abstract] [Full Text] [PDF]
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S. Y. Cheng and J. M. Bishop Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex PNAS, April 16, 2002; 99(8): 5442 - 5447. [Abstract] [Full Text] [PDF]
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J. W. Yoon, Y. Kita, D. J. Frank, R. R. Majewski, B. A. Konicek, M. A. Nobrega, H. Jacob, D. Walterhouse, and P. Iannaccone Gene Expression Profiling Leads to Identification of GLI1-binding Elements in Target Genes and a Role for Multiple Downstream Pathways in GLI1-induced Cell Transformation J. Biol. Chem., February 8, 2002; 277(7): 5548 - 5555. [Abstract] [Full Text] [PDF]
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M. K. Gustafsson, H. Pan, D. F. Pinney, Y. Liu, A. Lewandowski, D. J. Epstein, and C. P. Emerson Jr. Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification Genes & Dev., January 1, 2002; 16(1): 114 - 126. [Abstract] [Full Text] [PDF]
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Y. Mitani, H. Takahashi, and N. Satoh Regulation of the muscle-specific expression and function of an ascidian T-box gene, As-T2 Development, October 1, 2001; 128(19): 3717 - 3728. [Abstract] [Full Text] [PDF]
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 M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz GLI-2 Modulates Retroviral Gene Expression J. Virol., March 1, 2001; 75(5): 2301 - 2313. [Abstract] [Full Text]
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N. Tomioka, N. Osumi, Y. Sato, T. Inoue, S. Nakamura, H. Fujisawa, and T. Hirata Neocortical Origin and Tangential Migration of Guidepost Neurons in the Lateral Olfactory Tract J. Neurosci., August 1, 2000; 20(15): 5802 - 5812. [Abstract] [Full Text] [PDF]
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A. Borycki, A. M. Brown, and C. P. Emerson Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites Development, May 15, 2000; 127(10): 2075 - 2087. [Abstract] [PDF]
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D. Epstein, L Martinu, J. Michaud, K. Losos, C Fan, and A. Joyner Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS Development, January 11, 2000; 127(21): 4701 - 4709. [Abstract] [PDF]
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K. Liem, T. Jessell, and J Briscoe Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites Development, January 11, 2000; 127(22): 4855 - 4866. [Abstract] [PDF]
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P Aza-Blanc, H. Lin, A Ruiz i Altaba, and T. Kornberg Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities Development, January 10, 2000; 127(19): 4293 - 4301. [Abstract] [PDF]
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R Brewster, J. Mullor, and A Ruiz i Altaba Gli2 functions in FGF signaling during antero-posterior patterning Development, January 10, 2000; 127(20): 4395 - 4405. [Abstract] [PDF]
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F Muller, S Albert, P Blader, N Fischer, M Hallonet, and U Strahle Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS Development, January 9, 2000; 127(18): 3889 - 3897. [Abstract] [PDF]
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P Chen and R. Ellis TRA-1A regulates transcription of fog-3, which controls germ cell fate in C. elegans Development, January 7, 2000; 127(14): 3119 - 3129. [Abstract] [PDF]
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H. Park, C Bai, K. Platt, M. Matise, A Beeghly, C. Hui, M Nakashima, and A. Joyner Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development, January 4, 2000; 127(8): 1593 - 1605. [Abstract] [PDF]
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M. Kalff-Suske, A. Wild, J. Topp, M. Wessling, E.-M. Jacobsen, D. Bornholdt, H. Engel, H. Heuer, C. M. Aalfs, M. G. E. M. Ausems, et al. Point mutations throughout the GLI3 gene cause Greig cephalopolysyndactyly syndrome Hum. Mol. Genet., September 1, 1999; 8(9): 1769 - 1777. [Abstract] [Full Text] [PDF]
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P. Dai, H. Akimaru, Y. Tanaka, T. Maekawa, M. Nakafuku, and S. Ishii Sonic Hedgehog-induced Activation of the Gli1 Promoter Is Mediated by GLI3 J. Biol. Chem., March 19, 1999; 274(12): 8143 - 8152. [Abstract] [Full Text] [PDF]
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S. H. Shin, P. Kogerman, E. Lindstrom, R. Toftgard, and L. G. Biesecker GLI3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization PNAS, March 16, 1999; 96(6): 2880 - 2884. [Abstract] [Full Text] [PDF]
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 D. Stone, M Murone, S Luoh, W Ye, M. Armanini, A Gurney, H Phillips, J Brush, A Goddard, F. de Sauvage, et al. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli J. Cell Sci., January 12, 1999; 112(23): 4437 - 4448. [Abstract] [PDF]
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Q. Wang and R. Holmgren The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels Development, January 11, 1999; 126(22): 5097 - 5106. [Abstract] [PDF]
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H Sasaki, Y Nishizaki, C Hui, M Nakafuku, and H Kondoh Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling Development, January 9, 1999; 126(17): 3915 - 3924. [Abstract] [PDF]
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T Theil, G Alvarez-Bolado, A Walter, and U Ruther Gli3 is required for Emx gene expression during dorsal telencephalon development Development, January 8, 1999; 126(16): 3561 - 3571. [Abstract] [PDF]
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M. Matise, M Lustig, T Sakurai, M Grumet, and A. Joyner Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord Development, January 8, 1999; 126(16): 3649 - 3659. [Abstract] [PDF]
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K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway Development, January 6, 1999; 126(11): 2397 - 2407. [Abstract] [PDF]
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N Dahmane and A Ruiz-i-Altaba Sonic hedgehog regulates the growth and patterning of the cerebellum Development, January 6, 1999; 126(14): 3089 - 3100. [Abstract] [PDF]
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A Ruiz i Altaba Gli proteins encode context-dependent positive and negative functions: implications for development and disease Development, January 6, 1999; 126(14): 3205 - 3216. [Abstract] [PDF]
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F Muller, B Chang, S Albert, N Fischer, L Tora, and U Strahle Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord Development, January 5, 1999; 126(10): 2103 - 2116. [Abstract] [PDF]
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H Nishina, C Vaz, P Billia, M Nghiem, T Sasaki, J. De la Pompa, K Furlonger, C Paige, C Hui, K. Fischer, et al. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4 Development, January 2, 1999; 126(3): 505 - 516. [Abstract] [PDF]
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D. Epstein, A. McMahon, and A. Joyner Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms Development, January 1, 1999; 126(2): 281 - 292. [Abstract] [PDF]
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Y. Chen, N. Gallaher, R. H. Goodman, and S. M. Smolik Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus PNAS, March 3, 1998; 95(5): 2349 - 2354. [Abstract] [Full Text] [PDF]
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J. W. Yoon, C. Z. Liu, J. T. Yang, R. Swart, P. Iannaccone, and D. Walterhouse GLI Activates Transcription through a Herpes Simplex Viral Protein 16-Like Activation Domain J. Biol. Chem., February 6, 1998; 273(6): 3496 - 3501. [Abstract] [Full Text] [PDF]
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