|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 8 1553-1560, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
M Kofron, A Spagnuolo, M Klymkowsky, C Wylie and J Heasman
Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455, USA.
Catenins (alpha-, beta- and gamma- or plakoglobin) are cytoplasmic cadherin-associated proteins. Studies on cultured cells have suggested that both alpha-catenin and plakoglobin are important for the adhesive function of cadherins. alpha-catenin binds to both beta-catenin and plakoglobin and may link the cadherin/catenin complex to actin filaments. Separate domains of plakoglobin bind to cadherin and alpha-catenin, suggesting it may act as a bridge between these molecules. However, plakoglobin may have other activities: it is expressed in both desmosomal junctions in association with desmogleins and the cytoplasm in conjunction with APC, and previous work suggests it may act in a dorsal signalling pathway when overexpressed in Xenopus embryos. Here, we have studied the roles of alpha-catenin and plakoglobin directly, by depleting the maternal mRNAs coding for each of them in developing Xenopus embryos. We find that depletion of maternal alpha-catenin causes the loss of intercellular adhesion at the blastula stage, similar to that reported previously for EP cadherin. Depletion of plakoglobin results in a partial loss of adhesion, and a loss of embryonic shape, but does not affect dorsal signalling.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. K. Sawyer, N. J. Harris, K. C. Slep, U. Gaul, and M. Peifer The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction J. Cell Biol., July 13, 2009; 186(1): 57 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nandadasa, Q. Tao, N. R. Menon, J. Heasman, and C. Wylie N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements Development, April 15, 2009; 136(8): 1327 - 1338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rogers, M. Girolami, W. Kolch, K. M. Waters, T. Liu, B. Thrall, and H. S. Wiley Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models Bioinformatics, December 15, 2008; 24(24): 2894 - 2900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Scott and A. S. Yap Cinderella no longer: {alpha}-catenin steps out of cadherin's shadow J. Cell Sci., November 15, 2006; 119(22): 4599 - 4605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kofron, H. Puck, H. Standley, C. Wylie, R. Old, M. Whitman, and J. Heasman New roles for FoxH1 in patterning the early embryo Development, October 15, 2004; 131(20): 5065 - 5078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kofron, J. Heasman, S. A. Lang, and C. C. Wylie Plakoglobin is required for maintenance of the cortical actin skeleton in early Xenopus embryos and for cdc42-mediated wound healing J. Cell Biol., August 19, 2002; 158(4): 695 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhurinsky, M. Shtutman, and A. Ben-Ze'ev Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by beta -Catenin and Plakoglobin Mol. Cell. Biol., June 15, 2000; 20(12): 4238 - 4252. [Abstract] [Full Text]
|
|
|
|
|
|
J. Huelsken, R. Vogel, V. Brinkmann, B. Erdmann, C. Birchmeier, and W. Birchmeier Requirement for {beta}-Catenin in Anterior-Posterior Axis Formation in Mice J. Cell Biol., February 7, 2000; 148(3): 567 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Zhurinsky, M Shtutman, and A Ben-Ze'ev Plakoglobin and beta-catenin: protein interactions, regulation and biological roles J. Cell Sci., January 9, 2000; 113(18): 3127 - 3139. [Abstract] [PDF]
|
|
|
|
 |
|
 R. B. Presland and B. A. Dale Epithelial Structural Proteins of the Skin and Oral Cavity: Function in Health and Disease Critical Reviews in Oral Biology & Medicine, January 1, 2000; 11(4): 383 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cerdà, S. Reidenbach, S. Prätzel, and W. W. Franke Cadherin-Catenin Complexes During Zebrafish Oogenesis: Heterotypic Junctions Between Oocytes and Follicle Cells Biol Reprod, September 1, 1999; 61(3): 692 - 704. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Hecht, C. M. Litterst, O. Huber, and R. Kemler Functional Characterization of Multiple Transactivating Elements in beta -Catenin, Some of Which Interact with the TATA-binding Protein in Vitro J. Biol. Chem., June 18, 1999; 274(25): 18017 - 18025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fagotto, E.-h. Jho, L. Zeng, T. Kurth, T. Joos, C. Kaufmann, and F. Costantini Domains of Axin Involved in Protein-Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization J. Cell Biol., May 17, 1999; 145(4): 741 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Buchert, S. Schneider, V. Meskenaite, M. T. Adams, E. Canaani, T. Baechi, K. Moelling, and C. M. Hovens The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell-Cell Contact in the Brain J. Cell Biol., January 25, 1999; 144(2): 361 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I. Gallicano, P. Kouklis, C. Bauer, M. Yin, V. Vasioukhin, L. Degenstein, and E. Fuchs Desmoplakin Is Required Early in Development for Assembly of Desmosomes and Cytoskeletal Linkage J. Cell Biol., December 28, 1998; 143(7): 2009 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Yap, C. M. Niessen, and B. M. Gumbiner The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn J. Cell Biol., May 4, 1998; 141(3): 779 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Costa, W. Raich, C. Agbunag, B. Leung, J. Hardin, and J. R. Priess A Putative Catenin-Cadherin System Mediates Morphogenesis of the Caenorhabditis elegans Embryo J. Cell Biol., April 6, 1998; 141(1): 297 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. White, H. Aberle, and J.-P. Vincent Signaling and Adhesion Activities of Mammalian {beta}-Catenin and Plakoglobin in Drosophila J. Cell Biol., January 12, 1998; 140(1): 183 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N.M. Sehgal, B. M. Gumbiner, and L. F. Reichardt Antagonism of Cell Adhesion by an {alpha}-Catenin Mutant, and of the Wnt-signaling Pathway by {alpha}-Catenin in Xenopus Embryos J. Cell Biol., November 17, 1997; 139(4): 1033 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Miller and R. T. Moon Analysis of the Signaling Activities of Localization Mutants of {beta}-Catenin during Axis Specification in Xenopus J. Cell Biol., October 6, 1997; 139(1): 229 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Heasman Patterning the Xenopus blastula Development, January 11, 1997; 124(21): 4179 - 4191. [Abstract] [PDF]
|
|
