|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 124, Issue 9 1643-1651, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
HC Lu, JP Revelli, L Goering, C Thaller and G Eichele
Developmental Biology Program, and V. and M. McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA.
We show that retinoid receptor antagonists applied to the presumptive wing region block the formation of a zone of polarizing activity (ZPA). This suggests a direct relationship between retinoid signaling and the establishment of the ZPA. We provide evidence that the Hox gene, Hoxb-8, is a direct target of retinoid signaling since exogenously applied RA rapidly induces this gene in the absence of protein synthesis and, moreover, retinoid receptor antagonists down-regulate Hoxb-8 expression. In addition, we find that, in the lateral plate mesoderm, the domains of Hoxb-8 expression and of polarizing activity are coextensive. Taken together, these findings support the hypothesis that retinoids are required for the establishment of a ZPA, and that retinoids act, at least in part, through Hoxb-8, a gene associated with ZPA formation (Charite et al., 1994).
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. A. Gillis, R. D. Dahn, and N. H. Shubin Shared developmental mechanisms pattern the vertebrate gill arch and paired fin skeletons PNAS, April 7, 2009; 106(14): 5720 - 5724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Galloway and C. J. Tabin Classic limb patterning models and the work of Dennis Summerbell Development, August 15, 2008; 135(16): 2683 - 2687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grandel, K. Lun, G.-J. Rauch, M. Rhinn, T. Piotrowski, C. Houart, P. Sordino, A. M. Kuchler, S. Schulte-Merker, R. Geisler, et al. Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud Development, March 8, 2003; 129(12): 2851 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Ros, R. D. Dahn, M. Fernandez-Teran, K. Rashka, N. C. Caruccio, S. M. Hasso, J. J. Bitgood, J. J. Lancman, and J. F. Fallon The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb Development, February 1, 2003; 130(3): 527 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse Development, August 1, 2002; 129(15): 3563 - 3574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. te Welscher, M. Fernandez-Teran, M. A. Ros, and R. Zeller Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling Genes & Dev., February 15, 2002; 16(4): 421 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Lu, E. C. Swindell, W. D. Sierralta, G. Eichele, and C. Thaller Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud Development, July 1, 2001; 128(13): 2451 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway Development, May 15, 2000; 127(10): 2133 - 2142. [Abstract] [PDF]
|
|
|
|
 |
|
 L. E. Purton, I. D. Bernstein, and S. J. Collins All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells Blood, January 15, 2000; 95(2): 470 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tavares, T Tsukui, and J. Izpisua Belmonte Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development Development, January 12, 2000; 127(23): 5133 - 5144. [Abstract] [PDF]
|
|
|
|
|
|
J Charite, D. McFadden, and E. Olson The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development Development, January 6, 2000; 127(11): 2461 - 2470. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Warburton, J. Zhao, M. A. Berberich, and M. Bernfield Molecular embryology of the lung: then, now, and in the future Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L697 - L704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Zuniga and R Zeller Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity Development, January 1, 1999; 126(1): 13 - 21. [Abstract] [PDF]
|
|
|
|
|
|
G. R. Martin The roles of FGFs in the early development of vertebrate limbs Genes & Dev., June 1, 1998; 12(11): 1571 - 1586. [Full Text]
|
|
|
|
|
|
M Takahashi, K Tamura, D Buscher, H Masuya, S Yonei-Tamura, K Matsumoto, M Naitoh-Matsuo, J Takeuchi, K Ogura, T Shiroishi, et al. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development Development, January 11, 1998; 125(22): 4417 - 4425. [Abstract] [PDF]
|
|
|
|
|
|
S Qu, S. Tucker, J. Ehrlich, J. Levorse, L. Flaherty, R Wisdom, and T. Vogt Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly Development, January 7, 1998; 125(14): 2711 - 2721. [Abstract] [PDF]
|
|
|
|
|
|
V Knezevic, R De Santo, and S Mackem Continuing organizer function during chick tail development Development, January 5, 1998; 125(10): 1791 - 1801. [Abstract] [PDF]
|
|
|
|
|
|
T. Stratford, K Kostakopoulou, and M Maden Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb Development, January 11, 1997; 124(21): 4225 - 4234. [Abstract] [PDF]
|
|
