|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 1 33-39, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
T Hadrys, T Braun, S Rinkwitz-Brandt, HH Arnold and E Bober
Technical University Braunschweig, Department of Cell and Molecular Biology, Germany.
The inner ear develops from the otic vesicle, a one-cell-thick epithelium, which eventually transforms into highly complex structures including the sensory organs for balance (vestibulum) and hearing (cochlea). Several mouse inner ear mutations with hearing and balance defects have been described but for most the underlying genes have not been identified, for example, the genes controlling the development of the vestibular organs. Here, we report the inactivation of the homeobox gene, Nkx5-1, by homologous recombination in mice. This gene is expressed in vestibular structures throughout inner ear development. Mice carrying the Nkx5-1 null mutation exhibit behavioural abnormalities that resemble the typical hyperactivity and circling movements of the shaker/waltzer type mutants. The balance defect correlates with severe malformations of the vestibular organ in Nkx5-1(-/-) mutants, which fail to develop the semicircular canals. Nkx5-1 is the first ear-specific molecule identified to play a crucial role in the formation of the mammalian vestibular system.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Jiang, V. Horner, and J. Liu The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm Development, September 15, 2005; 132(18): 4119 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Lin, R. Cantos, M. Patente, and D. K. Wu Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling Development, May 15, 2005; 132(10): 2309 - 2318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Barald and M. W. Kelley From placode to polarization: new tunes in inner ear development Development, September 1, 2004; 131(17): 4119 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Raft, S. Nowotschin, J. Liao, and B. E. Morrow Suppression of neural fate and control of inner ear morphogenesis by Tbx1 Development, April 15, 2004; 131(8): 1801 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, L. Huang, Z.-B. Wei, D. Silvius, B. Tang, and P.-X. Xu The role of Six1 in mammalian auditory system development Development, September 1, 2003; 130(17): 3989 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hulander, A. E. Kiernan, S. R. Blomqvist, P. Carlsson, E.-J. Samuelsson, B. R. Johansson, K. P. Steel, and S. Enerback Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice Development, May 1, 2003; 130(9): 2013 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Shaw, X. Zhang, A. F. Russo, B. A. Amendt, S. Henderson, and V. Williams Homeobox Protein, Hmx3, in Postnatally Developing Rat Submandibular Glands J. Histochem. Cytochem., March 1, 2003; 51(3): 385 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Riccomagno, L. Martinu, M. Mulheisen, D. K. Wu, and D. J. Epstein Specification of the mammalian cochlea is dependent on Sonic hedgehog Genes & Dev., September 15, 2002; 16(18): 2365 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ponnio, Q. Burton, F. A. Pereira, D. K. Wu, and O. M. Conneely The Nuclear Receptor Nor-1 Is Essential for Proliferation of the Semicircular Canals of the Mouse Inner Ear Mol. Cell. Biol., February 1, 2002; 22(3): 935 - 945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, E. K. Chan, S. Baron, T. Van De Water, and T. Lufkin Hmx2 homeobox gene control of murine vestibular morphogenesis Development, December 15, 2001; 128(24): 5017 - 5029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Liu, F. A. Pereira, S. D. Price, M.-j. Chu, C. Shope, D. Himes, R. A. Eatock, W. E. Brownell, A. Lysakowski, and M.-J. Tsai Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems Genes & Dev., November 15, 2000; 14(22): 2839 - 2854. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu Patterning of the mammalian cochlea PNAS, October 24, 2000; 97(22): 11707 - 11713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vendrell, E. Carnicero, F. Giraldez, M. T. Alonso, and T. Schimmang Induction of inner ear fate by FGF3 Development, May 15, 2000; 127(10): 2011 - 2019. [Abstract] [PDF]
|
|
|
|
|
|
D Schulte and C. Cepko Two homeobox genes define the domain of EphA3 expression in the developing chick retina Development, January 12, 2000; 127(23): 5033 - 5045. [Abstract] [PDF]
|
|
|
|
|
|
M Salminen, B. Meyer, E Bober, and P Gruss Netrin 1 is required for semicircular canal formation in the mouse inner ear Development, January 1, 2000; 127(1): 13 - 22. [Abstract] [PDF]
|
|
|
|
 |
|
 B. A. Amendt, L. B. Sutherland, and A. F. Russo Transcriptional Antagonism between Hmx1 and Nkx2.5 for a Shared DNA-binding Site J. Biol. Chem., April 23, 1999; 274(17): 11635 - 11642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Riley, M Chiang, L Farmer, and R Heck The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1 Development, January 12, 1999; 126(24): 5669 - 5678. [Abstract] [PDF]
|
|
|
|
|
|
D Acampora, G. Merlo, L Paleari, B Zerega, M. Postiglione, S Mantero, E Bober, O Barbieri, A Simeone, and G Levi Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5 Development, January 9, 1999; 126(17): 3795 - 3809. [Abstract] [PDF]
|
|
|
|
|
|
M Xiang, W. Gao, T Hasson, and J. Shin Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells Development, January 10, 1998; 125(20): 3935 - 3946. [Abstract] [PDF]
|
|
