|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 12 2203-2212, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
A Ruiz i Altaba
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA. ria@saturn.med.nyu.edu
Within the developing vertebrate nervous system, it is not known how progenitor cells interpret the positional information provided by inducing signals or how the domains in which distinct groups of neural cells differentiate are defined. Gli proteins may be involved in these processes. In the frog neural plate, we have previously shown that the zinc finger transcription factor Gli1 is expressed in midline cells and mediates the effects of Shh inducing floor plate differentiation. In contrast, Gli2 and Gli3 are expressed throughout the neural plate except for the midline. Here, it is shown that Gli3 and Shh repress each other whereas Gli2, like Gli1, is a target of Shh signaling. However, only Gli1 can induce the differentiation of floor plate cells. In addition, Gli2 and Gli3 repress the ectopic induction of floor plate cells by Gli1 in co-injection assays and inhibit endogenous floor plate differentiation. The definition of the floor plate domain, therefore, appears to be defined by the antagonizing activities of Gli2 and Gli3 on Gli1 function. Because both Gli1 and Gli2 are induced by Shh, these results establish a regulatory feedback loop triggered by Shh that restricts floor plate cells to the midline. We have also previously shown that the Gli genes induce neuronal differentiation and here it is shown that there is specificity to the types of neurons the Gli proteins induce. Only Gli1 induces Nkx2.1/TTF-1(+) ventral forebrain neurons. Moreover, Gli2 and Gli3 inhibit their differentiation. In contrast, the differentiation of spinal motor neurons can be induced by the two ventrally expressed Gli genes, Gli1 and Gli2, suggesting that Gli2 directly mediates induction of motor neurons by Shh. In addition, Gli3 inhibits motor neuron differentiation by Gli2. Thus, combinatorial Gli function may pattern the neural tube, integrating positional information and cell type differentiation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Eichberger, A. Kaser, C. Pixner, C. Schmid, S. Klingler, M. Winklmayr, C. Hauser-Kronberger, F. Aberger, and A.-M. Frischauf GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells J. Biol. Chem., May 2, 2008; 283(18): 12426 - 12437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Galvin, H. Ye, D. J. Erstad, R. Feddersen, and C. Wetmore Gli1 Induces G2/M Arrest and Apoptosis in Hippocampal but Not Tumor-Derived Neural Stem Cells Stem Cells, April 1, 2008; 26(4): 1027 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fiaschi, B. Rozell, A. Bergstrom, R. Toftgard, and M. I. Kleman Targeted Expression of GLI1 in the Mammary Gland Disrupts Pregnancy-induced Maturation and Causes Lactation Failure J. Biol. Chem., December 7, 2007; 282(49): 36090 - 36101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shimoyama, M. Wada, F. Ikeda, K. Hata, T. Matsubara, A. Nifuji, M. Noda, K. Amano, A. Yamaguchi, R. Nishimura, et al. Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function Mol. Biol. Cell, July 1, 2007; 18(7): 2411 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Huangfu and K. V. Anderson Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates Development, January 1, 2006; 133(1): 3 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Cooper, K. P. Yu, M. Brueckner, L. L. Brailey, L. Johnson, J. M. McGrath, and A. E. Bale Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused Development, October 1, 2005; 132(19): 4407 - 4417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba Cooperative requirement of the Gli proteins in neurogenesis Development, July 15, 2005; 132(14): 3267 - 3279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube Genes & Dev., March 1, 2005; 19(5): 626 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Palma, D. A. Lim, N. Dahmane, P. Sanchez, T. C. Brionne, C. D. Herzberg, Y. Gitton, A. Carleton, A. Alvarez-Buylla, and A. R. i Altaba Sonic hedgehog controls stem cell behavior in the postnatal and adult brain Development, January 15, 2005; 132(2): 335 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Canudas, V. Di Giorgi-Gerevini, L. Iacovelli, G. Nano, M. D'Onofrio, A. Arcella, F. Giangaspero, C. Busceti, L. Ricci-Vitiani, G. Battaglia, et al. PHCCC, a Specific Enhancer of Type 4 Metabotropic Glutamate Receptors, Reduces Proliferation and Promotes Differentiation of Cerebellar Granule Cell Neuroprecursors J. Neurosci., November 17, 2004; 24(46): 10343 - 10352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Merchant, F. F. Vajdos, M. Ultsch, H. R. Maun, U. Wendt, J. Cannon, W. Desmarais, R. A. Lazarus, A. M. de Vos, and F. J. de Sauvage Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism Mol. Cell. Biol., October 1, 2004; 24(19): 8627 - 8641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ganss and A. Jheon ZINC FINGER TRANSCRIPTION FACTORS IN SKELETAL DEVELOPMENT Critical Reviews in Oral Biology & Medicine, September 1, 2004; 15(5): 282 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling Development, June 1, 2004; 131(11): 2521 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Zoltewicz, N. J. Stewart, R. Leung, and A. S. Peterson Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis Development, January 1, 2004; 131(1): 3 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Buttitta, R. Mo, C.-C. Hui, and C.-M. Fan Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction Development, December 22, 2003; 130(25): 6233 - 6243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Roessler, Y.-Z. Du, J. L. Mullor, E. Casas, W. P. Allen, G. Gillessen-Kaesbach, E. R. Roeder, J. E. Ming, A. R. i Altaba, and M. Muenke Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features PNAS, November 11, 2003; 100(23): 13424 - 13429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development Development, April 15, 2003; 130(8): 1549 - 1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Perron, S. Boy, M. A. Amato, A. Viczian, K. Koebernick, T. Pieler, and W. A. Harris A novel function for Hedgehog signalling in retinal pigment epithelium differentiation Development, April 15, 2003; 130(8): 1565 - 1577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes & Dev., November 15, 2002; 16(22): 2865 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sheng, S. Goich, A. Wang, M. Grachtchouk, L. Lowe, R. Mo, K. Lin, F. J. de Sauvage, H. Sasaki, C.-c. Hui, et al. Dissecting the Oncogenic Potential of Gli2: Deletion of an NH2-Terminal Fragment Alters Skin Tumor Phenotype Cancer Res., September 15, 2002; 62(18): 5308 - 5316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Huang, H. Roelink, and G. S. McKnight Protein Kinase A Deficiency Causes Axially Localized Neural Tube Defects in Mice J. Biol. Chem., May 24, 2002; 277(22): 19889 - 19896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Bai and A. L. Joyner Gli1 can rescue the in vivo function of Gli2 Development, December 15, 2001; 128(24): 5161 - 5172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Dahmane, P. Sanchez, Y. Gitton, V. Palma, T. Sun, M. Beyna, H. Weiner, and A. Ruiz i Altaba The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis Development, December 15, 2001; 128(24): 5201 - 5212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. M. Varga, A. Amores, K. E. Lewis, Y.-L. Yan, J. H. Postlethwait, J. S. Eisen, and M. Westerfield Zebrafish smoothened functions in ventral neural tube specification and axon tract formation Development, September 15, 2001; 128(18): 3497 - 3509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Glover Development of Specific Connectivity Between Premotor Neurons and Motoneurons in the Brain Stem and Spinal Cord Physiol Rev, April 1, 2000; 80(2): 615 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Epstein, L Martinu, J. Michaud, K. Losos, C Fan, and A. Joyner Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS Development, January 11, 2000; 127(21): 4701 - 4709. [Abstract] [PDF]
|
|
|
|
|
|
T Kitaguchi, T Nagai, K Nakata, J Aruga, and K Mikoshiba Zic3 is involved in the left-right specification of the Xenopus embryo Development, January 11, 2000; 127(22): 4787 - 4795. [Abstract] [PDF]
|
|
|
|
|
|
P Aza-Blanc, H. Lin, A Ruiz i Altaba, and T. Kornberg Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities Development, January 10, 2000; 127(19): 4293 - 4301. [Abstract] [PDF]
|
|
|
|
|
|
R Brewster, J. Mullor, and A Ruiz i Altaba Gli2 functions in FGF signaling during antero-posterior patterning Development, January 10, 2000; 127(20): 4395 - 4405. [Abstract] [PDF]
|
|
|
|
|
|
H. Park, C Bai, K. Platt, M. Matise, A Beeghly, C. Hui, M Nakashima, and A. Joyner Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development, January 4, 2000; 127(8): 1593 - 1605. [Abstract] [PDF]
|
|
|
|
|
|
O Cleaver, D. Seufert, and P. Krieg Endoderm patterning by the notochord: development of the hypochord in Xenopus Development, January 2, 2000; 127(4): 869 - 879. [Abstract] [PDF]
|
|
|
|
|
|
G. Wang, B. Wang, and J. Jiang Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus Genes & Dev., November 1, 1999; 13(21): 2828 - 2837. [Abstract] [Full Text]
|
|
|
|
|
|
P. Dai, H. Akimaru, Y. Tanaka, T. Maekawa, M. Nakafuku, and S. Ishii Sonic Hedgehog-induced Activation of the Gli1 Promoter Is Mediated by GLI3 J. Biol. Chem., March 19, 1999; 274(12): 8143 - 8152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. O. Karlstrom, W. S. Talbot, and A. F. Schier Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning Genes & Dev., February 15, 1999; 13(4): 388 - 393. [Abstract] [Full Text]
|
|
|
|
|
|
P. Franco, A. Paganelli, S. Lopez, and A. Carrasco Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis Development, January 10, 1999; 126(19): 4257 - 4265. [Abstract] [PDF]
|
|
|
|
|
|
H Sasaki, Y Nishizaki, C Hui, M Nakafuku, and H Kondoh Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling Development, January 9, 1999; 126(17): 3915 - 3924. [Abstract] [PDF]
|
|
|
|
|
|
A. Borycki, B Brunk, S Tajbakhsh, M Buckingham, C Chiang, and C. Emerson Sonic hedgehog controls epaxial muscle determination through Myf5 activation Development, January 9, 1999; 126(18): 4053 - 4063. [Abstract] [PDF]
|
|
|
|
|
|
T Theil, G Alvarez-Bolado, A Walter, and U Ruther Gli3 is required for Emx gene expression during dorsal telencephalon development Development, January 8, 1999; 126(16): 3561 - 3571. [Abstract] [PDF]
|
|
|
|
|
|
K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway Development, January 6, 1999; 126(11): 2397 - 2407. [Abstract] [PDF]
|
|
|
|
|
|
N Dahmane and A Ruiz-i-Altaba Sonic hedgehog regulates the growth and patterning of the cerebellum Development, January 6, 1999; 126(14): 3089 - 3100. [Abstract] [PDF]
|
|
|
|
|
|
A Ruiz i Altaba Gli proteins encode context-dependent positive and negative functions: implications for development and disease Development, January 6, 1999; 126(14): 3205 - 3216. [Abstract] [PDF]
|
|
|
|
|
|
D. Epstein, A. McMahon, and A. Joyner Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms Development, January 1, 1999; 126(2): 281 - 292. [Abstract] [PDF]
|
|
