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Development, Vol 125, Issue 13 2381-2395, Copyright © 1998 by Company of Biologists


JOURNAL ARTICLES

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis

F Reifers, H Bohli, EC Walsh, PH Crossley, DY Stainier and M Brand
Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany.

We describe the isolation of zebrafish Fgf8 and its expression during gastrulation, somitogenesis, fin bud and early brain development. By demonstrating genetic linkage and by analysing the structure of the Fgf8 gene, we show that acerebellar is a zebrafish Fgf8 mutation that may inactivate Fgf8 function. Homozygous acerebellar embryos lack a cerebellum and the midbrain-hindbrain boundary organizer. Fgf8 function is required to maintain, but not initiate, expression of Pax2.1 and other marker genes in this area. We show that Fgf8 and Pax2.1 are activated in adjacent domains that only later become overlapping, and activation of Fgf8 occurs normally in no isthmus embryos that are mutant for Pax2.1. These findings suggest that multiple signaling pathways are independently activated in the midbrain-hindbrain boundary primordium during gastrulation, and that Fgf8 functions later during somitogenesis to polarize the midbrain. Fgf8 is also expressed in a dorsoventral gradient during gastrulation and ectopically expressed Fgf8 can dorsalize embryos. Nevertheless, acerebellar mutants show only mild dorsoventral patterning defects. Also, in spite of the prominent role suggested for Fgf8 in limb development, the pectoral fins are largely unaffected in the mutants. Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others.
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The homeoprotein Xiro1 is required for midbrain-hindbrain boundary formation
Development, January 4, 2002; 129(7): 1609 - 1621.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
J. Y. H. Li and A. L. Joyner
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
Development, December 15, 2001; 128(24): 4979 - 4991.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
A. Sawada, M. Shinya, Y.-J. Jiang, A. Kawakami, A. Kuroiwa, and H. Takeda
Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
Development, December 1, 2001; 128(23): 4873 - 4880.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
M. Shinya, S. Koshida, A. Sawada, A. Kuroiwa, and H. Takeda
Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos
Development, November 1, 2001; 128(21): 4153 - 4164.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
H.-G. Belting, G. Hauptmann, D. Meyer, S. Abdelilah-Seyfried, A. Chitnis, C. Eschbach, I. Soll, C. Thisse, B. Thisse, K. B. Artinger, et al.
spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer
Development, November 1, 2001; 128(21): 4165 - 4176.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
S. van de Water, M. van de Wetering, J. Joore, J. Esseling, R. Bink, H. Clevers, and D. Zivkovic
Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant
Development, October 15, 2001; 128(20): 3877 - 3888.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
A. Tallafu{beta}, T. P. Wilm, M. Crozatier, P. Pfeffer, M. Wassef, and L. Bally-Cuif
The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development
Development, October 15, 2001; 128(20): 4021 - 4034.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
T. Sato, I. Araki, and H. Nakamura
Inductive signal and tissue responsiveness defining the tectum and the cerebellum
Development, July 1, 2001; 128(13): 2461 - 2469.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
M. Furthauer, F. Reifers, M. Brand, B. Thisse, and C. Thisse
sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish
Development, June 15, 2001; 128(12): 2175 - 2186.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
A Liu and A. Joyner
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region
Development, January 1, 2001; 128(2): 181 - 191.
[Abstract] [PDF]


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DevelopmentHome page
A. Majumdar, K. Lun, M. Brand, and I. A. Drummond
Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia
Development, May 15, 2000; 127(10): 2089 - 2098.
[Abstract] [PDF]


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GeneticsHome page
Y. Imai, B. Feldman, A. F. Schier, and W. S. Talbot
Analysis of Chromosomal Rearrangements Induced by Postmeiotic Mutagenesis With Ethylnitrosourea in Zebrafish
Genetics, May 1, 2000; 155(1): 261 - 272.
[Abstract] [Full Text]


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Hum Mol GenetHome page
P. Blader and U. Strahle
Zebrafish developmental genetics and central nervous system development
Hum. Mol. Genet., April 1, 2000; 9(6): 945 - 951.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
W. S. Talbot and N. Hopkins
Zebrafish mutations and functional analysis of the vertebrate genome
Genes & Dev., April 1, 2000; 14(7): 755 - 762.
[Full Text]


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DevelopmentHome page
H Grandel, B. Draper, and S Schulte-Merker
dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling
Development, January 10, 2000; 127(19): 4169 - 4178.
[Abstract] [PDF]


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J. Cell Sci.Home page
M Umbhauer, A Penzo-Mendez, L Clavilier, J Boucaut, and J Riou
Signaling specificities of fibroblast growth factor receptors in early Xenopus embryo
J. Cell Sci., January 8, 2000; 113(16): 2865 - 2875.
[Abstract] [PDF]


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DevelopmentHome page
S Shanmugalingam, C Houart, A Picker, F Reifers, R Macdonald, A Barth, K Griffin, M Brand, and S. Wilson
Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon
Development, January 6, 2000; 127(12): 2549 - 2561.
[Abstract] [PDF]


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DevelopmentHome page
J Xu, Z Liu, and D. Ornitz
Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures
Development, January 5, 2000; 127(9): 1833 - 1843.
[Abstract] [PDF]


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DevelopmentHome page
K. Adams, J. Maida, J. Golden, and R. Riddle
The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer
Development, January 5, 2000; 127(9): 1857 - 1867.
[Abstract] [PDF]


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DevelopmentHome page
S Winkler, F Loosli, T Henrich, Y Wakamatsu, and J Wittbrodt
The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye
Development, January 5, 2000; 127(9): 1911 - 1919.
[Abstract] [PDF]


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DevelopmentHome page
L Durbin, P Sordino, A Barrios, M Gering, C Thisse, B Thisse, C Brennan, A Green, S Wilson, and N Holder
Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish
Development, January 4, 2000; 127(8): 1703 - 1713.
[Abstract] [PDF]


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DevelopmentHome page
C Irving and I Mason
Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression
Development, January 1, 2000; 127(1): 177 - 186.
[Abstract] [PDF]


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DevelopmentHome page
F Reifers, E. Walsh, S Leger, D. Stainier, and M Brand
Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar)
Development, January 1, 2000; 127(2): 225 - 235.
[Abstract] [PDF]


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J Child NeurolHome page
K. J. Millen, J. H. Millonig, R. J. T. Wingate, J. Alder, and M. E. Hatten
Neurogenetics of the Cerebellar System
J Child Neurol, September 1, 1999; 14(9): 574 - 581.
[Abstract] [PDF]


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DevelopmentHome page
M Carl and J Wittbrodt
Graded interference with FGF signalling reveals its dorsoventral asymmetry at the mid-hindbrain boundary
Development, January 12, 1999; 126(24): 5659 - 5667.
[Abstract] [PDF]




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