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Development, Vol 125, Issue 13 2381-2395, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
F Reifers, H Bohli, EC Walsh, PH Crossley, DY Stainier and M Brand
Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany.
We describe the isolation of zebrafish Fgf8 and its expression during gastrulation, somitogenesis, fin bud and early brain development. By demonstrating genetic linkage and by analysing the structure of the Fgf8 gene, we show that acerebellar is a zebrafish Fgf8 mutation that may inactivate Fgf8 function. Homozygous acerebellar embryos lack a cerebellum and the midbrain-hindbrain boundary organizer. Fgf8 function is required to maintain, but not initiate, expression of Pax2.1 and other marker genes in this area. We show that Fgf8 and Pax2.1 are activated in adjacent domains that only later become overlapping, and activation of Fgf8 occurs normally in no isthmus embryos that are mutant for Pax2.1. These findings suggest that multiple signaling pathways are independently activated in the midbrain-hindbrain boundary primordium during gastrulation, and that Fgf8 functions later during somitogenesis to polarize the midbrain. Fgf8 is also expressed in a dorsoventral gradient during gastrulation and ectopically expressed Fgf8 can dorsalize embryos. Nevertheless, acerebellar mutants show only mild dorsoventral patterning defects. Also, in spite of the prominent role suggested for Fgf8 in limb development, the pectoral fins are largely unaffected in the mutants. Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others.
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H.-G. Belting, G. Hauptmann, D. Meyer, S. Abdelilah-Seyfried, A. Chitnis, C. Eschbach, I. Soll, C. Thisse, B. Thisse, K. B. Artinger, et al. spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer Development, November 1, 2001; 128(21): 4165 - 4176. [Abstract] [Full Text] [PDF]
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S. van de Water, M. van de Wetering, J. Joore, J. Esseling, R. Bink, H. Clevers, and D. Zivkovic Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant Development, October 15, 2001; 128(20): 3877 - 3888. [Abstract] [Full Text] [PDF]
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A. Tallafu{beta}, T. P. Wilm, M. Crozatier, P. Pfeffer, M. Wassef, and L. Bally-Cuif The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development Development, October 15, 2001; 128(20): 4021 - 4034. [Abstract] [Full Text] [PDF]
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T. Sato, I. Araki, and H. Nakamura Inductive signal and tissue responsiveness defining the tectum and the cerebellum Development, July 1, 2001; 128(13): 2461 - 2469. [Abstract] [Full Text] [PDF]
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M. Furthauer, F. Reifers, M. Brand, B. Thisse, and C. Thisse sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish Development, June 15, 2001; 128(12): 2175 - 2186. [Abstract] [Full Text] [PDF]
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A Liu and A. Joyner EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region Development, January 1, 2001; 128(2): 181 - 191. [Abstract] [PDF]
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A. Majumdar, K. Lun, M. Brand, and I. A. Drummond Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia Development, May 15, 2000; 127(10): 2089 - 2098. [Abstract] [PDF]
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 Y. Imai, B. Feldman, A. F. Schier, and W. S. Talbot Analysis of Chromosomal Rearrangements Induced by Postmeiotic Mutagenesis With Ethylnitrosourea in Zebrafish Genetics, May 1, 2000; 155(1): 261 - 272. [Abstract] [Full Text]
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 P. Blader and U. Strahle Zebrafish developmental genetics and central nervous system development Hum. Mol. Genet., April 1, 2000; 9(6): 945 - 951. [Abstract] [Full Text] [PDF]
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W. S. Talbot and N. Hopkins Zebrafish mutations and functional analysis of the vertebrate genome Genes & Dev., April 1, 2000; 14(7): 755 - 762. [Full Text]
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H Grandel, B. Draper, and S Schulte-Merker dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling Development, January 10, 2000; 127(19): 4169 - 4178. [Abstract] [PDF]
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M Umbhauer, A Penzo-Mendez, L Clavilier, J Boucaut, and J Riou Signaling specificities of fibroblast growth factor receptors in early Xenopus embryo J. Cell Sci., January 8, 2000; 113(16): 2865 - 2875. [Abstract] [PDF]
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S Shanmugalingam, C Houart, A Picker, F Reifers, R Macdonald, A Barth, K Griffin, M Brand, and S. Wilson Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon Development, January 6, 2000; 127(12): 2549 - 2561. [Abstract] [PDF]
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J Xu, Z Liu, and D. Ornitz Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures Development, January 5, 2000; 127(9): 1833 - 1843. [Abstract] [PDF]
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K. Adams, J. Maida, J. Golden, and R. Riddle The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer Development, January 5, 2000; 127(9): 1857 - 1867. [Abstract] [PDF]
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S Winkler, F Loosli, T Henrich, Y Wakamatsu, and J Wittbrodt The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye Development, January 5, 2000; 127(9): 1911 - 1919. [Abstract] [PDF]
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L Durbin, P Sordino, A Barrios, M Gering, C Thisse, B Thisse, C Brennan, A Green, S Wilson, and N Holder Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish Development, January 4, 2000; 127(8): 1703 - 1713. [Abstract] [PDF]
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C Irving and I Mason Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression Development, January 1, 2000; 127(1): 177 - 186. [Abstract] [PDF]
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F Reifers, E. Walsh, S Leger, D. Stainier, and M Brand Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar) Development, January 1, 2000; 127(2): 225 - 235. [Abstract] [PDF]
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 K. J. Millen, J. H. Millonig, R. J. T. Wingate, J. Alder, and M. E. Hatten Neurogenetics of the Cerebellar System J Child Neurol, September 1, 1999; 14(9): 574 - 581. [Abstract] [PDF]
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M Carl and J Wittbrodt Graded interference with FGF signalling reveals its dorsoventral asymmetry at the mid-hindbrain boundary Development, January 12, 1999; 126(24): 5659 - 5667. [Abstract] [PDF]
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