|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 13 2457-2467, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
R Holdeman, S Nehrt and S Strome
Department of Biology, Indiana University, Bloomington, IN 47405, USA.
A unique and essential feature of germ cells is their immortality. In Caenorhabditis elegans, germline immortality requires the maternal contribution from four genes, mes-2, mes-3, mes-4 and mes-6. We report here that mes-2 encodes a protein similar to the Drosophila Polycomb group protein, Enhancer of zeste, and in the accompanying paper that mes-6 encodes another Polycomb group protein. The Polycomb group is responsible for maintaining proper patterns of expression of the homeotic and other genes in Drosophila. It is thought that Polycomb group proteins form heteromeric complexes and control gene expression by altering chromatin conformation of target genes. As predicted from its similarity to a Polycomb group protein, MES-2 localizes to nuclei. MES-2 is found in germline nuclei in larval and adult worms and in all nuclei in early embryos. By the end of embryogenesis, MES-2 is detected primarily in the two primordial germ cells. The correct distribution of MES-2 requires the wild-type functions of mes-3 and mes-6. We hypothesize that mes-2 encodes a maternal regulator of gene expression in the early germline; its function is essential for normal early development and viability of germ cells.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Mosquna, A. Katz, E. L. Decker, S. A. Rensing, R. Reski, and N. Ohad Regulation of stem cell maintenance by the Polycomb protein FIE has been conserved during land plant evolution Development, July 15, 2009; 136(14): 2433 - 2444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Karakuzu, D. P. Wang, and S. Cameron MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans Development, March 15, 2009; 136(6): 943 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Joshi, E. A. Carrington, L. Wang, C. S. Ketel, E. L. Miller, R. S. Jones, and J. A. Simon Dominant Alleles Identify SET Domain Residues Required for Histone Methyltransferase of Polycomb Repressive Complex 2 J. Biol. Chem., October 10, 2008; 283(41): 27757 - 27766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Andersen and H. R. Horvitz Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development Development, August 15, 2007; 134(16): 2991 - 2999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, N. Jahren, M. L. Vargas, E. F. Andersen, J. Benes, J. Zhang, E. L. Miller, R. S. Jones, and J. A. Simon Alternative ESC and ESC-Like Subunits of a Polycomb Group Histone Methyltransferase Complex Are Differentially Deployed during Drosophila Development. Mol. Cell. Biol., April 1, 2006; 26(7): 2637 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhang, Y. Sun, E Tian, H. Deng, Y. Zhang, X. Luo, Q. Cai, H. Wang, J. Chai, and H. Zhang RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans. Development, March 1, 2006; 133(6): 1023 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Chesney, A. R. Kidd III, and J. Kimble gon-14 Functions With Class B and Class C Synthetic Multivulva Genes to Control Larval Growth in Caenorhabditis elegans Genetics, February 1, 2006; 172(2): 915 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Ketel, E. F. Andersen, M. L. Vargas, J. Suh, S. Strome, and J. A. Simon Subunit Contributions to Histone Methyltransferase Activities of Fly and Worm Polycomb Group Complexes Mol. Cell. Biol., August 15, 2005; 25(16): 6857 - 6868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chanvivattana, A. Bishopp, D. Schubert, C. Stock, Y.-H. Moon, Z. R. Sung, and J. Goodrich Interaction of Polycomb-group proteins controlling flowering in Arabidopsis Development, November 1, 2004; 131(21): 5263 - 5276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kawasaki, A. Amiri, Y. Fan, N. Meyer, S. Dunkelbarger, T. Motohashi, T. Karashima, O. Bossinger, and S. Strome The PGL Family Proteins Associate With Germ Granules and Function Redundantly in Caenorhabditis elegans Germline Development Genetics, June 1, 2004; 167(2): 645 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fridkin, E. Mills, A. Margalit, E. Neufeld, K. K. Lee, N. Feinstein, M. Cohen, K. L. Wilson, and Y. Gruenbaum Matefin, a Caenorhabditis elegans germ line-specific SUN-domain nuclear membrane protein, is essential for early embryonic and germ cell development PNAS, May 4, 2004; 101(18): 6987 - 6992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Jedrusik and E. Schulze Telomeric Position Effect Variegation in Saccharomyces cerevisiae by Caenorhabditis elegans Linker Histones Suggests a Mechanistic Connection between Germ Line and Telomeric Silencing Mol. Cell. Biol., May 15, 2003; 23(10): 3681 - 3691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Kelly, C. E. Schaner, A. F. Dernburg, M.-H. Lee, S. K. Kim, A. M. Villeneuve, and V. Reinke X-chromosome silencing in the germline of C. elegans Development, March 3, 2003; 129(2): 479 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fong, L. Bender, W. Wang, and S. Strome Regulation of the Different Chromatin States of Autosomes and X Chromosomes in the Germ Line of C. elegans Science, June 21, 2002; 296(5576): 2235 - 2238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xu, J. Paulsen, Y. Yoo, E. B. Goodwin, and S. Strome Caenorhabditis elegans MES-3 Is a Target of GLD-1 and Functions Epigenetically in Germline Development Genetics, November 1, 2001; 159(3): 1007 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xu and S. Strome Depletion of a Novel SET-Domain Protein Enhances the Sterility of mes-3 and mes-4 Mutants of Caenorhabditis elegans Genetics, November 1, 2001; 159(3): 1019 - 1029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Amiri, B. D. Keiper, I. Kawasaki, Y. Fan, Y. Kohara, R. E. Rhoads, and S. Strome An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans Development, October 15, 2001; 128(20): 3899 - 3912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Benard, B. McCright, Y. Zhang, S. Felkai, B. Lakowski, and S. Hekimi The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length Development, October 15, 2001; 128(20): 4045 - 4055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Birve, A. K. Sengupta, D. Beuchle, J. Larsson, J. A. Kennison, A. Rasmuson-Lestander, and J. Muller Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants Development, September 1, 2001; 128(17): 3371 - 3379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Jenuwein and C. D. Allis Translating the Histone Code Science, August 10, 2001; 293(5532): 1074 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O'Carroll, S. Erhardt, M. Pagani, S. C. Barton, M. A. Surani, and T. Jenuwein The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development Mol. Cell. Biol., July 1, 2001; 21(13): 4330 - 4336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xu, Y. Fong, and S. Strome The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos PNAS, April 24, 2001; 98(9): 5061 - 5066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Sharp RNA interference{---}2001 Genes & Dev., March 1, 2001; 15(5): 485 - 490. [Full Text]
|
|
|
|
 |
|
 D. R. Stauffer, T. L. Howard, T. Nyun, and S. M. Hollenberg CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression J. Cell Sci., January 7, 2001; 114(13): 2383 - 2393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jedrusik and E Schulze A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans Development, January 4, 2001; 128(7): 1069 - 1080. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Yadegari, T. Kinoshita, O. Lotan, G. Cohen, A. Katz, Y. Choi, A. Katz, K. Nakashima, J. J. Harada, R. B. Goldberg, et al. Mutations in the FIE and MEA Genes That Encode Interacting Polycomb Proteins Cause Parent-of-Origin Effects on Seed Development by Distinct Mechanisms PLANT CELL, December 1, 2000; 12(12): 2367 - 2382. [Abstract] [Full Text]
|
|
|
|
|
|
J. Ng, C. M. Hart, K. Morgan, and J. A. Simon A Drosophila ESC-E(Z) Protein Complex Is Distinct from Other Polycomb Group Complexes and Contains Covalently Modified ESC Mol. Cell. Biol., May 1, 2000; 20(9): 3069 - 3078. [Abstract] [Full Text]
|
|
|
|
|
|
L. Berkowitz and S Strome MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells Development, January 10, 2000; 127(20): 4419 - 4431. [Abstract] [PDF]
|
|
|
|
|
|
H. Chamberlin and J. Thomas The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans Development, January 2, 2000; 127(4): 713 - 723. [Abstract] [PDF]
|
|
|
|
|
|
J. Strouboulis, S. Damjanovski, D. Vermaak, F. Meric, and A. P. Wolffe Transcriptional Repression by XPc1, a New Polycomb Homolog in Xenopus laevis Embryos, Is Independent of Histone Deacetylase Mol. Cell. Biol., June 1, 1999; 19(6): 3958 - 3968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Subramaniam and G Seydoux nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans Development, January 11, 1999; 126(21): 4861 - 4871. [Abstract] [PDF]
|
|
|
|
|
|
G Seydoux and S Strome Launching the germline in Caenorhabditis elegans: regulation of gene expression in early germ cells Development, January 8, 1999; 126(15): 3275 - 3283. [Abstract] [PDF]
|
|
|
|
|
|
M. Luo, P. Bilodeau, A. Koltunow, E. S. Dennis, W. J. Peacock, and A. M. Chaudhury Genes controlling fertilization-independent seed development in Arabidopsis thaliana PNAS, January 5, 1999; 96(1): 296 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I Sahut-Barnola and D Pauli The Drosophila gene stand still encodes a germline chromatin-associated protein that controls the transcription of the ovarian tumor gene Development, January 5, 1999; 126(9): 1917 - 1926. [Abstract] [PDF]
|
|
|
|
|
|
W. Kelly and A Fire Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans Development, January 7, 1998; 125(13): 2451 - 2456. [Abstract] [PDF]
|
|
|
|
|
|
I Korf, Y Fan, and S Strome The Polycomb group in Caenorhabditis elegans and maternal control of germline development Development, January 7, 1998; 125(13): 2469 - 2478. [Abstract] [PDF]
|
|
|
|
 |
|
 N. M. Springer, O. N. Danilevskaya, P. Hermon, T. G. Helentjaris, R. L. Phillips, H. F. Kaeppler, and S. M. Kaeppler Sequence Relationships, Conserved Domains, and Expression Patterns for Maize Homologs of the Polycomb Group Genes E(z), esc, and E(Pc) Plant Physiology, April 1, 2002; 128(4): 1332 - 1345. [Abstract] [Full Text] [PDF]
|
|
