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Development, Vol 125, Issue 14 2665-2675, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
RS Viger, C Mertineit, JM Trasler and M Nemer
Laboratoire de Developpement et differenciation cardiaques, Institut de recherches cliniques de Montreal and Departement de pharmacologie, Universite de Montreal, Montreal, Quebec, Canada H2W 1R7.
Mammalian gonadal development and sexual differentiation are complex processes that require the coordinated expression of a specific set of genes in a strict spatiotemporal manner. Although some of these genes have been identified, the molecular pathways, including transcription factors, that are critical for the early events of lineage commitment and sexual dimorphism, remain poorly understood. GATA-4, a member of the GATA family of transcription factors, is present in the gonads and may be a regulator of gonadal gene expression. We have analyzed the ontogeny of gonadal GATA-4 expression by immunohistochemistry. GATA-4 protein was detected as early as embryonic day 11.5 in the primitive gonads of both XX and XY mouse embryos. In both sexes, GATA-4 specifically marked the developing somatic cell lineages (Sertoli in testis and granulosa in ovary) but not primordial germ cells. Interestingly, abundant GATA-4 expression was maintained in Sertoli cells throughout embryonic development but was markedly down-regulated shortly after the histological differentiation of the ovary on embryonic day 13.5. This pattern of expression suggested that GATA-4 might be involved in early gonadal development and possibly sexual dimorphism. Consistent with this hypothesis, we found that the Mullerian inhibiting substance promoter which harbors a conserved GATA element is a downstream target for GATA-4. Thus, transcription factor GATA-4 may be a new factor in the cascade of regulators that control gonadal development and sex differentiation in mammals.
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E. Silverman, S. Eimerl, and J. Orly CCAAT Enhancer-binding Protein beta and GATA-4 Binding Regions within the Promoter of the Steroidogenic Acute Regulatory Protein (StAR) Gene Are Required for Transcription in Rat Ovarian Cells J. Biol. Chem., June 18, 1999; 274(25): 17987 - 17996. [Abstract] [Full Text] [PDF]
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A. Murakami, J. Thurlow, and C. Dickson Retinoic Acid-regulated Expression of Fibroblast Growth Factor 3 Requires the Interaction between a Novel Transcription Factor and GATA-4 J. Biol. Chem., June 11, 1999; 274(24): 17242 - 17248. [Abstract] [Full Text] [PDF]
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F. Charron, P. Paradis, O. Bronchain, G. Nemer, and M. Nemer Cooperative Interaction between GATA-4 and GATA-6 Regulates Myocardial Gene Expression Mol. Cell. Biol., June 1, 1999; 19(6): 4355 - 4365. [Abstract] [Full Text] [PDF]
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A. Swain and R. Lovell-Badge Mammalian sex determination: a molecular drama Genes & Dev., April 1, 1999; 13(7): 755 - 767. [Full Text]
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I. Ketola, N. Rahman, J. Toppari, M. Bielinska, S. B. Porter-Tinge, J. S. Tapanainen, I. T. Huhtaniemi, D. B. Wilson, and M. Heikinheimo Expression and Regulation of Transcription Factors GATA-4 and GATA-6 in Developing Mouse Testis Endocrinology, March 1, 1999; 140(3): 1470 - 1480. [Abstract] [Full Text]
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E. C. Svensson, R. L. Tufts, C. E. Polk, and J. M. Leiden Molecular cloning of FOG-2: A modulator of transcription factor GATA-4 in cardiomyocytes PNAS, February 2, 1999; 96(3): 956 - 961. [Abstract] [Full Text] [PDF]
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P. d. S. Barbara, B. Moniot, F. Poulat, B. Boizet, and P. Berta Steroidogenic Factor-1 Regulates Transcription of the Human Anti-mullerian Hormone Receptor J. Biol. Chem., November 6, 1998; 273(45): 29654 - 29660. [Abstract] [Full Text] [PDF]
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J. D. Molkentin The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6. UBIQUITOUSLY EXPRESSED REGULATORS OF TISSUE-SPECIFIC GENE EXPRESSION J. Biol. Chem., December 8, 2000; 275(50): 38949 - 38952. [Full Text] [PDF]
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