|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 15 2951-2962, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
T Klein and AM Arias
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK. thk21@cus.cam.ac.uk
The Notch signalling pathway plays an important role during the development of the wing primordium, especially of the wing blade and margin. In these processes, the activity of Notch is controlled by the activity of the dorsal specific nuclear protein Apterous, which regulates the expression of the Notch ligand, Serrate, and the Fringe signalling molecule. The other Notch ligand, Delta, also plays a role in the development and patterning of the wing. It has been proposed that Fringe modulates the ability of Serrate and Delta to signal through Notch and thereby restricts Notch signalling to the dorsoventral boundary of the developing wing blade. Here we report the results of experiments aimed at establishing the relationships between Fringe, Serrate and Delta during wing development. We find that Serrate is not required for the initiation of wing development but rather for the expansion and early patterning of the wing primordium. We provide evidence that, at the onset of wing development, Delta is under the control of apterous and might be the Notch ligand in this process. In addition, we find that Fringe function requires Su(H). Our results suggest that Notch signalling during wing development relies on careful balances between positive and dominant negative interactions between Notch ligands, some of which are mediated by Fringe.
This article has been cited by other articles:
|
|
 |
|
  K. Sato, T. M. Matsunaga, R. Futahashi, T. Kojima, K. Mita, Y. Banno, and H. Fujiwara Positional Cloning of a Bombyx Wingless Locus flugellos (fl) Reveals a Crucial Role for fringe That Is Specific for Wing Morphogenesis Genetics, June 1, 2008; 179(2): 875 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hayward, T. Kalmar, and A. Martinez Arias Wnt/Notch signalling and information processing during development Development, February 1, 2008; 135(3): 411 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U.-M. Fiuza and A. M. Arias Cell and molecular biology of Notch J. Endocrinol., September 1, 2007; 194(3): 459 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sato and A. Tomlinson Dorsal-ventral midline signaling in the developing Drosophila eye Development, February 15, 2007; 134(4): 659 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Thomas and D. J. van Meyel The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression Development, February 1, 2007; 134(3): 591 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Tsukumo, K. Hirose, Y. Maekawa, K. Kishihara, and K. Yasutomo Lunatic Fringe Controls T Cell Differentiation through Modulating Notch Signaling J. Immunol., December 15, 2006; 177(12): 8365 - 8371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gonzalez, C. Chaouiya, and D. Thieffry Dynamical Analysis of the Regulatory Network Defining the Dorsal-Ventral Boundary of the Drosophila Wing Imaginal Disc Genetics, November 1, 2006; 174(3): 1625 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rampal, A. S. Y. Li, D. J. Moloney, S. A. Georgiou, K. B. Luther, A. Nita-Lazar, and R. S. Haltiwanger Lunatic Fringe, Manic Fringe, and Radical Fringe Recognize Similar Specificity Determinants in O-Fucosylated Epidermal Growth Factor-like Repeats J. Biol. Chem., December 23, 2005; 280(51): 42454 - 42463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Xu, L. Lei, and K. D. Irvine Regions of Drosophila Notch That Contribute to Ligand Binding and the Modulatory Influence of Fringe J. Biol. Chem., August 26, 2005; 280(34): 30158 - 30165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development, May 15, 2005; 132(10): 2319 - 2332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kong, J. Glickman, M. Subramaniam, A. Shahsafaei, K. P. Allamneni, J. C. Aster, J. Sklar, and M. E. Sunday Functional diversity of notch family genes in fetal lung development Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L1075 - L1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Yan, Y. Gu, W. X. Li, and R. J. Fleming Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development Development, January 15, 2004; 131(2): 285 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lei, A. Xu, V. M. Panin, and K. D. Irvine An O-fucose site in the ligand binding domain inhibits Notch activation Development, December 29, 2003; 130(26): 6411 - 6421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Okajima, A. Xu, and K. D. Irvine Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe J. Biol. Chem., October 24, 2003; 278(43): 42340 - 42345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sasamura, N. Sasaki, F. Miyashita, S. Nakao, H. O. Ishikawa, M. Ito, M. Kitagawa, K. Harigaya, E. Spana, D. Bilder, et al. neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions Development, October 15, 2003; 130(20): 4785 - 4795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. van Meyel, J. B. Thomas, and A. D. Agulnick Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo Development, May 1, 2003; 130(9): 1915 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Dansereau, M. D. Lunke, A. Finkielsztein, M. A. Russell, and W. J. Brook hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster Development, March 14, 2003; 129(24): 5553 - 5566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Dunwoodie, M. Clements, D. B. Sparrow, X. Sa, R. A. Conlon, and R. S. P. Beddington Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm Development, January 4, 2002; 129(7): 1795 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Larsen, L. M. Zeltser, and A. Lumsden Boundary Formation and Compartition in the Avian Diencephalon J. Neurosci., July 1, 2001; 21(13): 4699 - 4711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O'Keefe and J. Thomas Drosophila wing development in the absence of dorsal identity Development, January 3, 2001; 128(5): 703 - 710. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Shimizu, S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 Mol. Cell. Biol., September 15, 2000; 20(18): 6913 - 6922. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Seppo and M. Tiemeyer Function and structure of Drosophila glycans Glycobiology, April 1, 2000; 10(8): 751 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Klein, L Seugnet, M Haenlin, and A Martinez Arias Two different activities of Suppressor of Hairless during wing development in Drosophila Development, January 8, 2000; 127(16): 3553 - 3566. [Abstract] [PDF]
|
|
|
|
|
|
N Lawrence, T Klein, K Brennan, and A Martinez Arias Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila Development, January 7, 2000; 127(14): 3185 - 3195. [Abstract] [PDF]
|
|
|
|
|
|
A. Parks, K. Klueg, J. Stout, and M. Muskavitch Ligand endocytosis drives receptor dissociation and activation in the Notch pathway Development, January 4, 2000; 127(7): 1373 - 1385. [Abstract] [PDF]
|
|
|
|
|
|
K. Shimizu, S. Chiba, K. Kumano, N. Hosoya, T. Takahashi, Y. Kanda, Y. Hamada, Y. Yazaki, and H. Hirai Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors. ASSESSMENT BY QUANTITATIVE METHODS J. Biol. Chem., November 12, 1999; 274(46): 32961 - 32969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Harada, P. Kettunen, H.-S. Jung, T. Mustonen, Y. A. Wang, and I. Thesleff Localization of Putative Stem Cells in Dental Epithelium and Their Association with Notch and FGF Signaling J. Cell Biol., October 4, 1999; 147(1): 105 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Klueg and M. Muskavitch Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila J. Cell Sci., January 10, 1999; 112(19): 3289 - 3297. [Abstract] [PDF]
|
|
|
|
|
|
S. Bishop, T Klein, A. Arias, and J. Couso Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch Development, January 7, 1999; 126(13): 2993 - 3003. [Abstract] [PDF]
|
|
|
|
|
|
C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]
|
|
|
|
|
|
T Klein and A. Arias The vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila Development, January 2, 1999; 126(5): 913 - 925. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis, D. Tyler, J de Celis, and S. Bray Notch signalling mediates segmentation of the Drosophila leg Development, January 12, 1998; 125(23): 4617 - 4626. [Abstract] [PDF]
|
|
|
|
|
|
T. Jacobsen, K Brennan, A. Arias, and M. Muskavitch Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila Development, January 11, 1998; 125(22): 4531 - 4540. [Abstract] [PDF]
|
|
|
|
|
|
K. Shimizu, S. Chiba, T. Saito, K. Kumano, T. Takahashi, and H. Hirai Manic Fringe and Lunatic Fringe Modify Different Sites of the Notch2 Extracellular Region, Resulting in Different Signaling Modulation J. Biol. Chem., July 6, 2001; 276(28): 25753 - 25758. [Abstract] [Full Text] [PDF]
|
|
