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Development, Vol 125, Issue 15 2995-3003, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Cytoplasmic polyadenylation of Toll mRNA is required for dorsal-ventral patterning in Drosophila embryogenesis

JA Schisa and S Strickland
Department of Pharmacology and Program in Genetics, University at Stony Brook, Stony Brook, NY 11794-8651, USA.

Toll encodes a receptor that is critical for dorsal-ventral patterning in the early Drosophila embryo. Previous data have suggested that the accumulation of Toll protein in the embryo temporally correlates with elongation of the poly (A) tail of the message. Here, we demonstrate that Toll mRNA is translationally activated by regulated cytoplasmic polyadenylation. We also identify a 192 nucleotide regulatory element in the Toll 3' UTR that is necessary for robust translational activation of Toll mRNA and also regulates polyadenylation. UV crosslinking analyses suggest that two proteins bind specifically to the 192 nucleotide element. One or both of these proteins may be factors that are required for translational regulation or cytoplasmic polyadenylation. These studies demonstrate that regulated polyadenylation plays a critical role in the Drosophila dorsal-ventral patterning system.


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© The Company of Biologists Ltd 1998