spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schisa, J. A.
Right arrow Articles by Strickland, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schisa, J. A.
Right arrow Articles by Strickland, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 125, Issue 15 2995-3003, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Cytoplasmic polyadenylation of Toll mRNA is required for dorsal-ventral patterning in Drosophila embryogenesis

JA Schisa and S Strickland
Department of Pharmacology and Program in Genetics, University at Stony Brook, Stony Brook, NY 11794-8651, USA.

Toll encodes a receptor that is critical for dorsal-ventral patterning in the early Drosophila embryo. Previous data have suggested that the accumulation of Toll protein in the embryo temporally correlates with elongation of the poly (A) tail of the message. Here, we demonstrate that Toll mRNA is translationally activated by regulated cytoplasmic polyadenylation. We also identify a 192 nucleotide regulatory element in the Toll 3' UTR that is necessary for robust translational activation of Toll mRNA and also regulates polyadenylation. UV crosslinking analyses suggest that two proteins bind specifically to the 192 nucleotide element. One or both of these proteins may be factors that are required for translational regulation or cytoplasmic polyadenylation. These studies demonstrate that regulated polyadenylation plays a critical role in the Drosophila dorsal-ventral patterning system.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
D. J. Bornemann, S. Park, S. Phin, and R. Warrior
A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo
Development, March 15, 2008; 135(6): 1039 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. M. Choi, I. Barash, and R. E. Rhoads
Insulin and Prolactin Synergistically Stimulate {beta}-Casein Messenger Ribonucleic Acid Translation by Cytoplasmic Polyadenylation
Mol. Endocrinol., July 1, 2004; 18(7): 1670 - 1686.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
J. D. Richter
Cytoplasmic Polyadenylation in Development and Beyond
Microbiol. Mol. Biol. Rev., June 1, 1999; 63(2): 446 - 456.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1998