The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis

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JOURNAL ARTICLES

The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis

D Dufort, L Schwartz, K Harpal and J Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.

During early embryogenesis, the transcription factor HNF3beta is expressed in visceral and definitive endoderm, node, notochord and floorplate. A targeted mutation in the HNF3&bgr ; gene results in the lack of a definitive node and notochord. Furthermore, lack of HNF3beta results in failure of proper primitive streak elongation. To address whether HNF3beta is required in visceral endoderm, we have used tetraploid embryo-ES cell aggregations to generate chimeric mouse embryos with wild-type visceral endoderm and homozygous mutant HNF3beta embryonic ectoderm or vice versa. Replacing the visceral endoderm of mutant HNF3beta embryos rescued proper primitive streak elongation and, conversely, mutant visceral endoderm imposed a severe embryonic-extraembryonic constriction on wild-type embryonic ectoderm. Restoration of normal streak morphogenesis was not sufficient to allow formation of the node and notochord in HNF3beta mutant embryos. Thus, our results demonstrate that HNF3beta has two separate roles in primitive streak formation. One is to act within the visceral endoderm to promote proper streak morphogenesis. The second is autonomous to the node and its precursors and involves specification of node and notochord cell fates. HNF3beta mutant embryos rescued for the embryonic-extraembryonic constriction developed further than mutant embryos, allowing examination of later roles for HNF3beta. We show that such mutant embryos lack foregut and midgut endoderm. In addition, left-right asymmetry is affected in the mutant embryos.

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				H.-J. Chen, C.-M. Lin, C.-S. Lin, R. Perez-Olle, C. L. Leung, and R. K.H. Liem The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway Genes & Dev., July 15, 2006; 20(14): 1933 - 1945. [Abstract] [Full Text] [PDF]

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				P. Georgiades and J. Rossant Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development Development, March 15, 2006; 133(6): 1059 - 1068. [Abstract] [Full Text] [PDF]

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				H. Ben Abdelkhalek, A. Beckers, K. Schuster-Gossler, M. N. Pavlova, H. Burkhardt, H. Lickert, J. Rossant, R. Reinhardt, L. C. Schalkwyk, I. Muller, et al. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation Genes & Dev., July 15, 2004; 18(14): 1725 - 1736. [Abstract] [Full Text] [PDF]

				J.-F. Pare, D. Malenfant, C. Courtemanche, M. Jacob-Wagner, S. Roy, D. Allard, and L. Belanger The Fetoprotein Transcription Factor (FTF) Gene Is Essential to Embryogenesis and Cholesterol Homeostasis and Is Regulated by a DR4 Element J. Biol. Chem., May 14, 2004; 279(20): 21206 - 21216. [Abstract] [Full Text] [PDF]

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