|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 17 3291-3299, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
G Udolph, J Urban, G Rusing, K Luer and GM Technau
Institut fur Genetik, Universitat Mainz, Saarstrasse 21, D-55122 Mainz, Germany.
The Drosophila ventral nerve cord derives from a stereotype population of about 30 neural stem cells, the neuroblasts, per hemineuromere. Previous experiments provided indications for inductive signals at ventral sites of the neuroectoderm that confer neuroblast identities. Using cell lineage analysis, molecular markers and cell transplantation, we show here that EGF receptor signalling plays an instructive role in CNS patterning and exerts differential effects on dorsoventral subpopulations of neuroblasts. The Drosophila EGF receptor (DER) is capable of cell autonomously specifiying medial and intermediate neuroblast cell fates. DER signalling appears to be most critical for proper development of intermediate neuroblasts and less important for medial neuroblasts. It is not required for lateral neuroblast lineages or for cells to adopt CNS midline cell fate. Thus, dorsoventral patterning of the CNS involves both DER-dependent and -independent regulatory pathways. Furthermore, we discuss the possibility that different phases of DER activation exist during neuroectodermal patterning with an early phase independent of midline-derived signals.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Egger, J. M Chell, and A. H Brand Insights into neural stem cell biology from flies Phil Trans R Soc B, January 12, 2008; 363(1489): 39 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Yool Aquaporins: Multiple Roles in the Central Nervous System Neuroscientist, October 1, 2007; 13(5): 470 - 485. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Brody and W. F. Odenwald Cellular diversity in the developing nervous system: a temporal view from Drosophila Development, March 10, 2003; 129(16): 3763 - 3770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Yanochko and A. J. Yool Regulated Cationic Channel Function in Xenopus Oocytes Expressing Drosophila Big Brain J. Neurosci., April 1, 2002; 22(7): 2530 - 2540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zhao and J. B. Skeath The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm Development, January 3, 2002; 129(5): 1165 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Udolph, P Rath, and W Chia A requirement for Notch in the genesis of a subset of glial cells in the Drosophila embryonic central nervous system which arise through asymmetric divisions Development, January 4, 2001; 128(8): 1457 - 1466. [Abstract] [PDF]
|
|
|
|
|
|
A Schmid, A Chiba, and C. Doe Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets Development, January 11, 1999; 126(21): 4653 - 4689. [Abstract] [PDF]
|
|
|
|
|
|
D Arendt and K Nubler-Jung Comparison of early nerve cord development in insects and vertebrates Development, January 6, 1999; 126(11): 2309 - 2325. [Abstract] [PDF]
|
|
|
|
|
|
J. Skeath The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo Development, January 9, 1998; 125(17): 3301 - 3312. [Abstract] [PDF]
|
|
|
|
 |
|
 X. Shao, K. Koizumi, N. Nosworthy, D.-P. Tan, W. Odenwald, and M. Nirenberg Regulatory DNA required for vnd/NK-2 homeobox gene expression pattern in neuroblasts PNAS, January 8, 2002; 99(1): 113 - 117. [Abstract] [Full Text] [PDF]
|
|
