|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 19 3865-3873, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
RJ Sommer, A Eizinger, KZ Lee, B Jungblut, A Bubeck and I Schlak
Max-Planck Institut fur Entwicklungsbiologie, Abt. Zellbiologie, Spemannstrasse 35, Germany.
In the two nematode species Caenorhabditis elegans and Pristionchus pacificus the vulva equivalence group in the central body region is specified by the Hox gene lin-39. C. elegans lin-39 mutants are vulvaless and the vulval precursor cells fuse with the surrounding hypodermis, whereas in P. pacificus lin-39 mutants the vulval precursor cells die by apoptosis. Mechanistically, LIN-39 might inhibit non-vulval fate (cell fusion in C. elegans, apoptosis in P. pacificus), promote vulval fate or do both. To study the mechanism of lin-39 function, we isolated P. pacificus cell death mutants and identified mutations in ced-3. Surprisingly, P. pacificus ced-3; lin-39 double mutants form a functional vulva in the absence of LIN-39 activity. Thus, in P. pacificus lin-39 specifies the vulva equivalence group by inhibiting programmed cell death. Furthermore, these data reveal an important difference in a later function of lin-39 between the two species. In C. elegans, LIN-39 specifies vulval cell fates in response to inductive RAS signaling, and in P. pacificus LIN-39 is not required for vulval induction. Thus, the comparative analysis indicates that lin-39 has distinct functions in both species although the gene is acting in a homologous developmental system.
This article has been cited by other articles:
|
|
 |
|
  R. L. Hong, H. Witte, and R. J. Sommer Natural variation in Pristionchus pacificus insect pheromone attraction involves the protein kinase EGL-4 PNAS, June 3, 2008; 105(22): 7779 - 7784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Yi and R. J. Sommer The pax-3 gene is involved in vulva formation in Pristionchus pacificus and is a target of the Hox gene lin-39 Development, September 1, 2007; 134(17): 3111 - 3119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Miguel-Aliaga and S. Thor Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity Development, December 15, 2004; 131(24): 6093 - 6105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Joshi and D. M. Eisenmann The Caenorhabditis elegans pvl-5 Gene Protects Hypodermal Cells From ced-3-Dependent, ced-4-Independent Cell Death Genetics, June 1, 2004; 167(2): 673 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Srinivasan, G. W. Otto, U. Kahlow, R. Geisler, and R. J. Sommer AppaDB: an AcedB database for the nematode satellite organism Pristionchus pacificus Nucleic Acids Res., January 1, 2004; 32(90001): D421 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-Z. Lee, A. Eizinger, R. Nandakumar, S. C. Schuster, and R. J. Sommer Limited microsynteny between the genomes of Pristionchus pacificus and Caenorhabditis elegans Nucleic Acids Res., May 15, 2003; 31(10): 2553 - 2560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gutierrez, L. Knoch, H. Witte, and R. J. Sommer Functional specificity of the nematode Hox gene mab-5 Development, March 1, 2003; 130(5): 983 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Louvet-Vallee, I. Kolotuev, B. Podbilewicz, and M.-A. Felix Control of Vulval Competence and Centering in the Nematode Oscheius sp. 1 CEW1 Genetics, January 1, 2003; 163(1): 133 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Srinivasan, W. Sinz, C. Lanz, A. Brand, R. Nandakumar, G. Raddatz, H. Witte, H. Keller, I. Kipping, A. Pires-daSilva, et al. A Bacterial Artificial Chromosome-Based Genetic Linkage Map of the Nematode Pristionchus pacificus Genetics, September 1, 2002; 162(1): 129 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Seipp, J. Schmich, and T. Leitz Apoptosis - a death-inducing mechanism tightly linked with morphogenesis in Hydractina echinata (Cnidaria, Hydrozoa) Development, December 1, 2001; 128(23): 4891 - 4898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Jungblut, A. Pires-daSilva, and R. J. Sommer Formation of the egg-laying system in Pristionchus pacificus requires complex interactions between gonadal, mesodermal and epidermal tissues and does not rely on single cell inductions Development, September 15, 2001; 128(18): 3395 - 3404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Grandien and R. J. Sommer Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences Genes & Dev., August 15, 2001; 15(16): 2161 - 2172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Dichtel, S. Louvet-Vallée, M. E. Viney, M.-A. Félix, and P. W. Sternberg Control of Vulval Cell Division Number in the Nematode Oscheius/Dolichorhabditis sp. CEW1 Genetics, January 1, 2001; 157(1): 183 - 197. [Abstract] [Full Text]
|
|
|
|
|
|
B Jungblut and R. Sommer Novel cell-cell interactions during vulva development in Pristionchus pacificus Development, January 8, 2000; 127(15): 3295 - 3303. [Abstract] [PDF]
|
|
