|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 20 3925-3934, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
C Rodriguez-Esteban, JW Schwabe, JD Pena, DE Rincon-Limas, J Magallon, J Botas and JC Belmonte
Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA.
apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Tzchori, T. F. Day, P. J. Carolan, Y. Zhao, C. A. Wassif, L. Li, M. Lewandoski, M. Gorivodsky, P. E. Love, F. D. Porter, et al. LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth Development, April 15, 2009; 136(8): 1375 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fernandes, G. Gutin, H. Alcorn, S. K. McConnell, and J. M. Hebert Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly Development, November 1, 2007; 134(21): 3789 - 3794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Pueyo and J. P. Couso Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development Development, July 1, 2004; 131(13): 3107 - 3120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Gupta, M. Wang, and P. W. Sternberg The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development Development, June 15, 2003; 130(12): 2589 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vogel-Hopker and H. Rohrer The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs) Development, March 4, 2003; 129(4): 983 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Milan, U. Weihe, S. Tiong, W. Bender, and S. M. Cohen msh specifies dorsal cell fate in the Drosophila wing Development, September 1, 2001; 128(17): 3263 - 3268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Wang, A. Simcox, and G. Campbell Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development Genes & Dev., September 15, 2000; 14(18): 2271 - 2276. [Abstract] [Full Text]
|
|
|
|
|
|
J. Pueyo, M. Galindo, S. Bishop, and J. Couso Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1 Development, January 12, 2000; 127(24): 5391 - 5402. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Arman, R. Haffner-Krausz, M. Gorivodsky, and P. Lonai Fgfr2 is required for limb outgrowth and lung-branching morphogenesis PNAS, October 12, 1999; 96(21): 11895 - 11899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Rincon-Limas, C.-H. Lu, I. Canal, M. Calleja, C. Rodriguez-Esteban, J. C. Izpisua-Belmonte, and J. Botas Conservation of the expression and function of apterous orthologs in Drosophila and mammals PNAS, March 2, 1999; 96(5): 2165 - 2170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Cavodeassi, R Diez Del Corral, S Campuzano, and M Dominguez Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins Development, January 11, 1999; 126(22): 4933 - 4942. [Abstract] [PDF]
|
|
