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Development, Vol 125, Issue 20 3977-3987, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
TE Haerry, O Khalsa, MB O'Connor and KA Wharton
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
In Drosophila wing discs, a morphogen gradient of DPP has been proposed to determine the transcriptional response thresholds of the downstream genes sal and omb. We present evidence that the concentration of the type I receptor TKV must be low to allow long-range DPP diffusion. Low TKV receptor concentrations result, however, in low signaling activity. To enhance signaling at low DPP concentrations, we find that a second ligand, GBB, augments DPP/TKV activity. GBB signals primarily through the type I receptor SAX, which synergistically enhances TKV signaling and is required for proper OMB expression. We show that OMB expression in wing discs requires synergistic signaling by multiple ligands and receptors to overcome the limitations imposed on DPP morphogen function by receptor concentration levels.
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