spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LeMosy, E. K.
Right arrow Articles by Hashimoto, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LeMosy, E. K.
Right arrow Articles by Hashimoto, C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 125, Issue 20 4045-4053, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo

EK LeMosy, D Kemler and C Hashimoto
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8002, USA. carl.hashimoto@yale.edu.

The establishment of embryonic dorsoventral polarity in Drosophila depends on a signaling mechanism in which the signal for ventral development is locally produced. This mechanism requires the activity of the nudel gene in ovarian follicle cells, which provide dorsoventral positional information for the embryo. The nudel gene product, a large mosaic protein with a central serine protease domain, has been proposed to function in locally triggering a protease cascade that produces the ventral signal. Here we provide evidence that the serine protease activity of the Nudel protein is essential for embryonic dorsoventral polarity and that the active Nudel protease is generated by autoproteolytic cleavage of a zymogen form. Activation of the Nudel protease is independent of the other known proteases involved in dorsoventral polarity establishment and appears to occur symmetrically on the surface of the embryo. Our findings suggest that Nudel protease activation initiates the protease cascade that produces the ventral signal, but that spatial regulation occurring downstream of Nudel protease activation localizes the cascade to the ventral side of the embryo.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
C. D'Alterio, D. D.D. Tran, M. W.Y. A. Yeung, M. S.H. Hwang, M. A. Li, C. J. Arana, V. K. Mulligan, M. Kubesh, P. Sharma, M. Chase, et al.
Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli
J. Cell Biol., November 7, 2005; 171(3): 549 - 558.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
W. Tadros, S. A. Houston, A. Bashirullah, R. L. Cooperstock, J. L. Semotok, B. H. Reed, and H. D. Lipshitz
Regulation of Maternal Transcript Destabilization During Egg Activation in Drosophila
Genetics, July 1, 2003; 164(3): 989 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Rose, E. K. LeMosy, A. M. Cantwell, D. Banerjee-Roy, J. B. Skeath, and E. Di Cera
Three-dimensional Models of Proteases Involved in Patterning of the Drosophila Embryo. CRUCIAL ROLE OF PREDICTED CATION BINDING SITES
J. Biol. Chem., March 21, 2003; 278(13): 11320 - 11330.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
G. Jimenez, A. Gonzalez-Reyes, and J. Casanova
Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis
Genes & Dev., April 15, 2002; 16(8): 913 - 918.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
D. Andrenacci, F. M. Cernilogar, C. Taddei, D. Rotoli, V. Cavaliere, F. Graziani, and G. Gargiulo
Specific domains drive VM32E protein distribution and integration in Drosophila eggshell layers
J. Cell Sci., January 8, 2001; 114(15): 2819 - 2829.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
A. Seppo and M. Tiemeyer
Function and structure of Drosophila glycans
Glycobiology, April 1, 2000; 10(8): 751 - 760.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H Araujo and E Bier
sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo
Development, January 8, 2000; 127(16): 3631 - 3644.
[Abstract] [PDF]

Home page
 GeneticsHome page
E. K. LeMosy, C. L. Leclerc, and C. Hashimoto
Biochemical Defects of Mutant nudel Alleles Causing Early Developmental Arrest or Dorsalization of the Drosophila Embryo
Genetics, January 1, 2000; 154(1): 247 - 257.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
W. Yan, N. Sheng, M. Seto, J. Morser, and Q. Wu
Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart
J. Biol. Chem., May 21, 1999; 274(21): 14926 - 14935.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. K. LeMosy, Y.-Q. Tan, and C. Hashimoto
Activation of a protease cascade involved in patterning the Drosophila embryo
PNAS, April 24, 2001; 98(9): 5055 - 5060.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1998