|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 21 4225-4234, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
A Kispert, S Vainio and AP McMahon
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. kispert@immunbio.mpg.de.
Development of the mammalian kidney is initiated by ingrowth of the ureteric bud into the metanephric blastema. In response to signal(s) from the ureter, mesenchymal cells condense, aggregate into pretubular clusters, and undergo epithelialisation to form simple epithelial tubules. Subsequent morphogenesis and differentiation of the tubular epithelium lead to the establishment of a functional nephron. Here we demonstrate that Wnt-4, a secreted glycoprotein which is required for tubule formation, is sufficient to trigger tubulogenesis in isolated metanephric mesenchyme, whereas Wnt-11 which is expressed in the tip of the growing ureter is not. Wnt-4 signaling depends on cell contact and sulphated glycosaminoglycans and is only required for triggering tubulogenesis but not for later events. The Wnt-4 signal can be replaced by other members of the Wnt gene family including Wnt-1, Wnt-3a, Wnt-7a and Wnt-7b. Further, dorsal spinal cord, which has been thought to mimic ureteric signaling in tubule induction induces Wnt-4 mutant as well as wild-type mesenchyme suggesting that spinal cord derived signal(s) most likely act by mimicking the normal mesenchymal action of Wnt-4. These results lend additional support to the notion that Wnt-4 is a key auto-regulator of the mesenchymal to epithelial transformation that underpins nephrogenesis adding another level of complexity in the hierarchy of molecular events mediating tubulogenesis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Liu, N. Chattopadhyay, S. Qin, C. Szekeres, T. Vasylyeva, Z. X. Mahoney, M. Taglienti, C. M. Bates, H. A. Chapman, J. H. Miner, et al. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis Development, March 1, 2009; 136(5): 843 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yu, T. J. Carroll, J. Rajagopal, A. Kobayashi, Q. Ren, and A. P. McMahon A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney Development, January 1, 2009; 136(1): 161 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Otto, C. Schmidt, G. Luke, S. Allen, P. Valasek, F. Muntoni, D. Lawrence-Watt, and K. Patel Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration J. Cell Sci., September 1, 2008; 121(17): 2939 - 2950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. El-Dahr, K. Aboudehen, and Z. Saifudeen Transcriptional control of terminal nephron differentiation Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1273 - F1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Lewis, P.-L. Khoo, R. A. De Young, K. Steiner, C. Wilcock, M. Mukhopadhyay, H. Westphal, R. V. Jamieson, L. Robb, and P. P. L. Tam Dkk1 and Wnt3 interact to control head morphogenesis in the mouse Development, May 15, 2008; 135(10): 1791 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bovolenta, P. Esteve, J. M. Ruiz, E. Cisneros, and J. Lopez-Rios Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease J. Cell Sci., March 15, 2008; 121(6): 737 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Schmidt-Ott, T. N. H. Masckauchan, X. Chen, B. J. Hirsh, A. Sarkar, J. Yang, N. Paragas, V. A. Wallace, D. Dufort, P. Pavlidis, et al. {beta}-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors Development, September 1, 2007; 134(17): 3177 - 3190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kopan, H.-T. Cheng, and K. Surendran Molecular Insights into Segmentation along the Proximal Distal Axis of the Nephron J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2014 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Park, M. T. Valerius, and A. P. McMahon Wnt/{beta}-catenin signaling regulates nephron induction during mouse kidney development Development, July 1, 2007; 134(13): 2533 - 2539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vigneau, K. Polgar, G. Striker, J. Elliott, D. Hyink, O. Weber, H.-J. Fehling, G. Keller, C. Burrow, and P. Wilson Mouse Embryonic Stem Cell-Derived Embryoid Bodies Generate Progenitors That Integrate Long Term into Renal Proximal Tubules In Vivo J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1709 - 1720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kuure, A. Popsueva, M. Jakobson, K. Sainio, and H. Sariola Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1130 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Figueira, N. Di Girolamo, M. T. Coroneo, and D. Wakefield The Phenotype of Limbal Epithelial Stem Cells Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 144 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kohno, T. Okamoto, T. Ishibe, S. Nagayama, Y. Shima, K. Nishijo, K. R. Shibata, K. Fukiage, S. Otsuka, D. Uejima, et al. Expression of Claudin7 Is Tightly Associated with Epithelial Structures in Synovial Sarcomas and Regulated by an Ets Family Transcription Factor, ELF3 J. Biol. Chem., December 15, 2006; 281(50): 38941 - 38950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. Lin, J.-Y. Wang, Y.-T. Huang, Y.-H. Kuo, K. Surendran, and F.-S. Wang Wnt/beta-Catenin Signaling Modulates Survival of High Glucose-Stressed Mesangial Cells J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2812 - 2820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chi, P. Itaranta, S. Zhang, and S. Vainio Sprouty2 Is Involved in Male Sex Organogenesis by Controlling Fibroblast Growth Factor 9-Induced Mesonephric Cell Migration to the Developing Testis Endocrinology, August 1, 2006; 147(8): 3777 - 3788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. James, C. N. Kamei, Q. Wang, R. Jiang, and T. M. Schultheiss Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells Development, August 1, 2006; 133(15): 2995 - 3004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Blumenthal, S. Ehlers, J. Lauber, J. Buer, C. Lange, T. Goldmann, H. Heine, E. Brandt, and N. Reiling The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation Blood, August 1, 2006; 108(3): 965 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Torban, A. Dziarmaga, D. Iglesias, L. L. Chu, T. Vassilieva, M. Little, M. Eccles, M. Discenza, J. Pelletier, and P. Goodyer PAX2 Activates WNT4 Expression during Mammalian Kidney Development J. Biol. Chem., May 5, 2006; 281(18): 12705 - 12712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ayyanan, G. Civenni, L. Ciarloni, C. Morel, N. Mueller, K. Lefort, A. Mandinova, W. Raffoul, M. Fiche, G. P. Dotto, et al. Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism PNAS, March 7, 2006; 103(10): 3799 - 3804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Osafune, M. Takasato, A. Kispert, M. Asashima, and R. Nishinakamura Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay Development, January 1, 2006; 133(1): 151 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-a. Nakaya, K. Biris, T. Tsukiyama, S. Jaime, J. A. Rawls, and T. P. Yamaguchi Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation Development, December 15, 2005; 132(24): 5425 - 5436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Desmots, H. R. Russell, Y. Lee, K. Boyd, and P. J. McKinnon The Reaper-Binding Protein Scythe Modulates Apoptosis and Proliferation during Mammalian Development Mol. Cell. Biol., December 1, 2005; 25(23): 10329 - 10337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kim and G. R. Dressler Nephrogenic Factors Promote Differentiation of Mouse Embryonic Stem Cells into Renal Epithelia J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3527 - 3534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Challen, B. Gardiner, G. Caruana, X. Kostoulias, G. Martinez, M. Crowe, D. F. Taylor, J. Bertram, M. Little, and S. M. Grimmond Temporal and spatial transcriptional programs in murine kidney development Physiol Genomics, October 17, 2005; 23(2): 159 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Perantoni, O. Timofeeva, F. Naillat, C. Richman, S. Pajni-Underwood, C. Wilson, S. Vainio, L. F. Dove, and M. Lewandoski Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development Development, September 1, 2005; 132(17): 3859 - 3871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Grieshammer, C. Cebrian, R. Ilagan, E. Meyers, D. Herzlinger, and G. R. Martin FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons Development, September 1, 2005; 132(17): 3847 - 3857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kettunen, S. Loes, T. Furmanek, K. Fjeld, I. H. Kvinnsland, O. Behar, T. Yagi, H. Fujisawa, S. Vainio, M. Taniguchi, et al. Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgf{beta}1 regulate semaphorin 3a expression in the dental mesenchyme Development, January 15, 2005; 132(2): 323 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Hou, Y. Tan, M. Li, S. K. Dey, and S. K. Das Canonical Wnt Signaling Is Critical to Estrogen-Mediated Uterine Growth Mol. Endocrinol., December 1, 2004; 18(12): 3035 - 3049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fahnert, J. Veijola, G. Roel, M. K. Karkkainen, A. Railo, O. Destree, S. Vainio, and P. Neubauer Murine Wnt-1 with an Internal c-myc Tag Recombinantly Produced in Escherichia coli Can Induce Intracellular Signaling of the Canonical Wnt Pathway in Eukaryotic Cells J. Biol. Chem., November 12, 2004; 279(46): 47520 - 47527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chi, S. Zhang, Y. Lin, R. Prunskaite-Hyyrylainen, R. Vuolteenaho, P. Itaranta, and S. Vainio Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development Development, July 15, 2004; 131(14): 3345 - 3356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Vrljicak, D. Myburgh, A. K. Ryan, M. A. van Rooijen, C. L. Mummery, and I. R. Gupta Smad expression during kidney development Am J Physiol Renal Physiol, April 1, 2004; 286(4): F625 - F633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Brophy, K. M. Lang, and G. R. Dressler The Secreted Frizzled Related Protein 2 (SFRP2) Gene Is a Target of the Pax2 Transcription Factor J. Biol. Chem., December 26, 2003; 278(52): 52401 - 52405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schumacher, R. Strehl, and W. W. Minuth Urea Restrains Aldosterone-Induced Development of Peanut Agglutinin-Binding on Embryonic Renal Collecting Duct Epithelia J. Am. Soc. Nephrol., November 1, 2003; 14(11): 2758 - 2766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Cheng, J. H. Miner, M. Lin, M. G. Tansey, K. Roth, and R. Kopan {gamma}-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney Development, October 15, 2003; 130(20): 5031 - 5042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang, F. A. Pereira, D. Beasley, and H. Zheng Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis Development, October 15, 2003; 130(20): 5019 - 5029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hsieh, S. M. Mulders, R. R. Friis, A. Dharmarajan, and J. S. Richards Expression and Localization of Secreted Frizzled-Related Protein-4 in the Rodent Ovary: Evidence for Selective Up-Regulation in Luteinized Granulosa Cells Endocrinology, October 1, 2003; 144(10): 4597 - 4606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Majumdar, S. Vainio, A. Kispert, J. McMahon, and A. P. McMahon Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development Development, July 15, 2003; 130(14): 3175 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Gummow, J. N. Winnay, and G. D. Hammer Convergence of Wnt Signaling and Steroidogenic Factor-1 (SF-1) on Transcription of the Rat Inhibin {alpha} Gene J. Biol. Chem., July 11, 2003; 278(29): 26572 - 26579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Morrisey Wnt Signaling and Pulmonary Fibrosis Am. J. Pathol., May 1, 2003; 162(5): 1393 - 1397. [Full Text] [PDF]
|
|
|
|
|
|
S. Maretto, M. Cordenonsi, S. Dupont, P. Braghetta, V. Broccoli, A. B. Hassan, D. Volpin, G. M. Bressan, and S. Piccolo Mapping Wnt/beta -catenin signaling during mouse development and in colorectal tumors PNAS, March 18, 2003; 100(6): 3299 - 3304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Li, M. Guo, A. Borczuk, C. A. Powell, M. Wei, H. M. Thaker, R. Friedman, U. Klein, and B. Tycko Gene Expression in Wilms' Tumor Mimics the Earliest Committed Stage in the Metanephric Mesenchymal-Epithelial Transition Am. J. Pathol., June 1, 2002; 160(6): 2181 - 2190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Moon, B. Bowerman, M. Boutros, and N. Perrimon The Promise and Perils of Wnt Signaling Through beta -Catenin Science, May 31, 2002; 296(5573): 1644 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hsieh, M. A. Johnson, N. M. Greenberg, and J. S. Richards Regulated Expression of Wnts and Frizzleds at Specific Stages of Follicular Development in the Rodent Ovary Endocrinology, March 1, 2002; 143(3): 898 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O'N. Wiggan, M. P. Fadel, and P. A. Hamel Pax3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion J. Cell Sci., January 2, 2002; 115(3): 517 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Richards, D. L. Russell, S. Ochsner, M. Hsieh, K. H. Doyle, A. E. Falender, Y. K. Lo, and S. C. Sharma Novel Signaling Pathways That Control Ovarian Follicular Development, Ovulation, and Luteinization Recent Prog. Horm. Res., January 1, 2002; 57(1): 195 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Helmbrecht, A. Kispert, R. von Wasielewski, and G. Brabant Identification of a Wnt/{beta}-Catenin Signaling Pathway in Human Thyroid Cells Endocrinology, December 1, 2001; 142(12): 5261 - 5266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zeitvogel, R. Baumann, and A. Starzinski-Powitz Identification of an Invasive, N-Cadherin-Expressing Epithelial Cell Type in Endometriosis Using a New Cell Culture Model Am. J. Pathol., November 1, 2001; 159(5): 1839 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nishinakamura, Y. Matsumoto, K. Nakao, K. Nakamura, A. Sato, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, S. Scully, D. L. Lacey, et al. Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development Development, August 15, 2001; 128(16): 3105 - 3115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Bryant, J. E. Schmid, S. E. Fenton, A. R. Buckalew, and B. D. Abbott Teratogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Mice Lacking the Expression of EGF and/or TGF-{{alpha}} Toxicol. Sci., July 1, 2001; 62(1): 103 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. BULLOCK, T. M. JOHNSON, Q. BAO, R. C. HUGHES, P. J. D. WINYARD, and A. S. WOOLF Galectin-3 Modulates Ureteric Bud Branching in Organ Culture of the Developing Mouse Kidney J. Am. Soc. Nephrol., March 1, 2001; 12(3): 515 - 523. [Abstract] [Full Text]
|
|
|
|
|
|
Y Lin, S Zhang, M Rehn, P Itaranta, J Tuukkanen, R Heljasvaara, H Peltoketo, T Pihlajaniemi, and S Vainio Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C Development, January 5, 2001; 128(9): 1573 - 1585. [Abstract] [PDF]
|
|
|
|
|
|
S. Plisov, K Yoshino, L. Dove, K. Higinbotham, J. Rubin, and A. Perantoni TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis Development, January 4, 2001; 128(7): 1045 - 1057. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Maiti, R. Alam, C. I. Amos, and V. Huff Frequent Association of {beta}-Catenin and WT1 Mutations in Wilms Tumors Cancer Res., November 1, 2000; 60(22): 6288 - 6292. [Abstract] [Full Text]
|
|
|
|
|
|
T. J. CARROLL and A. P. McMAHON Secreted Molecules in Metanephric Induction J. Am. Soc. Nephrol., November 1, 2000; 11(90002): S116 - S119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brisken, A. Heineman, T. Chavarria, B. Elenbaas, J. Tan, S. K. Dey, J. A. McMahon, A. P. McMahon, and R. A. Weinberg Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling Genes & Dev., March 15, 2000; 14(6): 650 - 654. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. D. Lander and S. B. Selleck The Elusive Functions of Proteoglycans: In Vivo Veritas J. Cell Biol., January 24, 2000; 148(2): 227 - 232. [Full Text] [PDF]
|
|
|
|
|
|
H Lickert, C Domon, G Huls, C Wehrle, I Duluc, H Clevers, B. Meyer, J. Freund, and R Kemler Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine Development, January 9, 2000; 127(17): 3805 - 3813. [Abstract] [PDF]
|
|
|
|
|
|
A Louvi and M Wassef Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding Development, January 9, 2000; 127(18): 4061 - 4071. [Abstract] [PDF]
|
|
|
|
|
|
C. Lee, L. Buttitta, N. May, A Kispert, and C. Fan SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm Development, January 1, 2000; 127(1): 109 - 118. [Abstract] [PDF]
|
|
|
|
|
|
R. Koesters, R. Ridder, A. Kopp-Schneider, D. Betts, V. Adams, F. Niggli, J. Briner, and M. v. K. Doeberitz Mutational Activation of the {beta}-Catenin Proto-Oncogene Is a Common Event in the Development of Wilms' Tumors Cancer Res., August 1, 1999; 59(16): 3880 - 3882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Clark and J. F. Bertram Molecular regulation of nephron endowment Am J Physiol Renal Physiol, April 1, 1999; 276(4): F485 - F497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Patapoutian, C. Backus, A. Kispert, and L. F. Reichardt Regulation of Neurotrophin-3 Expression by Epithelial-Mesenchymal Interactions: The Role of Wnt Factors Science, February 19, 1999; 283(5405): 1180 - 1183. [Abstract] [Full Text]
|
|
|
|
|
|
U Muller and A. Brandli Cell adhesion molecules and extracellular-matrix constituents in kidney development and disease J. Cell Sci., January 11, 1999; 112(22): 3855 - 3867. [Abstract] [PDF]
|
|
|
|
|
|
D. B. Stewart, A. I. M. Barth, and W. J. Nelson Differential Regulation of Endogenous Cadherin Expression in Madin-Darby Canine Kidney Cells by Cell-Cell Adhesion and Activation of beta -Catenin Signaling J. Biol. Chem., June 30, 2000; 275(27): 20707 - 20716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Surendran, S. P. McCaul, and T. C. Simon A role for Wnt-4 in renal fibrosis Am J Physiol Renal Physiol, March 1, 2002; 282(3): F431 - F441. [Abstract] [Full Text] [PDF]
|
|
